Coating of High Density Polyethylene (HDPE) with Silver Compounds and Their Antimicrobial Activity in vitro

2019 ◽  
Vol 11 (21) ◽  
pp. 59-68 ◽  
Author(s):  
Nada Djokic ◽  
Rod Precht ◽  
S. Djokic
Keyword(s):  
Antimicrobial Activity ◽  
High Density Polyethylene ◽  
High Density ◽  
Silver Compounds

In vitro evaluation of biocompatibility of beta-tricalcium phosphate-reinforced high-density polyethylene; an orthopedic composite

2005 ◽  
Vol 75A (1) ◽  
pp. 14-22 ◽  
Author(s):  
S. SH. Homaeigohar ◽  
M. A. Shokrgozar ◽  
A. Yari Sadi ◽  
A. Khavandi ◽  
J. Javadpour ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
High Density Polyethylene ◽  
High Density ◽  
In Vitro Evaluation ◽  
Beta Tricalcium Phosphate

Biocompatibility of CaSiO3 /High-Density Polyethylene Composites Prepared by Hot-Pressing

2006 ◽  
Vol 309-311 ◽  
pp. 1161-1164 ◽  
Author(s):  
Miho Tanuma ◽  
Yoshikazu Kameshima ◽  
Akira Nakajima ◽  
Kiyoshi Okada ◽  
Shigeo Asai ◽  
...  
Keyword(s):  
Hot Pressing ◽  
High Density Polyethylene ◽  
Ceramic Powder ◽  
High Density ◽  
Apatite Formation ◽  
Composite Surface ◽  
Ceramic Particles ◽  
Fast Bone ◽  
The Matrix

We have reported that CaSiO3 ceramics show very fast bone-like apatite formation in simulated body fluid (SBF). However, CaSiO3 ceramics have disadvantages in their mechanical properties and shapability. It is therefore more effective to develop composites of CaSiO3 particles dispersed in a matrix of polymer or metal. Such composites are usually prepared by homogeneously blending the ceramic powder with the matrix component. This method is, however, ineffective for the preparation of biocompatible polymers or metals because only the surfaces containing accidentally-exposed ceramic particles play a role in generating apatite in SBF. It is therefore necessary to add a large volume of ceramic powder and also to abrade the surface to expose more of the ceramic particles. In this study, CaSiO3/high-density polyethylene (HDPE) composites were prepared by hot-pressing to introduce surface CaSiO3 particles and their biocompatibilities were evaluated under in vitro conditions using SBF. CaSiO3 powders were spread on a HDPE plate and hot-pressed at 140oC and 4.9-14.7 MPa for 2 min. The composite sample (about 10×10×1 mm3 in size) was immersed in 30ml SBF (sample/solution ratio of 2.5 g/l) at 36.5oC. After 14 days soaking, the apatite product particles covered most of the composite surface and formed apatite layers. Bone-like apatite particles were formed only on the surface regions containing exposed CaSiO3 particles but no apatite was formed on the CaSiO3 particles buried in the HDPE matrix. The results show that this surface deposition method is very effective in developing biocompatibility in the composites using very small amounts of CaSiO3 powder (about <1 %v) compared with results reported for hydroxyapatite and AW glass-ceramic powders (requiring about 40 %v). It is also found that the inhomogeneous state of the CaSiO3 particles in the surface of the present composites strongly influences their biocompatibility. It will be necessary to improve the homogeneity of CaSiO3 dispersion in the surface of the composites to achieve a more uniform surface apatite layer.

Investigation on the morphology, thermal properties, and in vitro cytotoxicity of the fish scale particulates filled high-density polyethylene composite

2019 ◽  
Vol 28 (4) ◽  
pp. 285-296
Author(s):  
C Balaji Ayyanar ◽  
K Marimuthu
Keyword(s):  
High Density Polyethylene ◽  
Natural Fiber ◽  
Polymeric Materials ◽  
In Vitro Cytotoxicity ◽  
High Density ◽  
Thermoplastic Composites ◽  
Fish Scale ◽  
Scanning Calorimetry ◽  
Polyethylene Composite

The high-density polyethylene (HDPE) and fish scale particulates are in the ratio of 10:3 (matrix 100 g:filler 30 g) which is filled and blended with thermoplastic composites and are then fabricated by the injection molding machine. In this work, the thermal energy absorption is obtained as 103.9 J g−1 that melts onset temperature at 121.75°C and melts peak temperature at 129.98°C of the specimen using differential scanning calorimetry instrument. A gradual mass degradation and decomposition of the prepared samples were analyzed from the thermogravimetric analysis. Evaluation of microstructure, surface morphology, and elemental analysis was carried out using field emission scanning electron microscope. The presence of functional groups in the polymeric materials was identified using Fourier transform infrared spectroscopy. The cytotoxicity testing of composites has been carried out using MG 63 cell line. In these studies, five different volumes of liquid extract of the prepared specimen having different concentrations (10, 20, 30, 40, and 50 μL) were allowed to interact with fresh cell culture medium for 24 h. The cell viability, cell morphology, and the levels of cytotoxicity of the composite specimen were studied as per ISO 10993:12 and ISO 10993:5 test standards. It was found that the natural fiber filled composite showed none to slight cytotoxic reactivity to MG-63 cells after 24 h contact. The cytotoxicity level of fish scale particulate filled HDPE composite material was compared with standard reactivity level and it was confirmed to have low toxic level (none to slight).

In vitro biomechanical testing of different configurations of acrylic external skeletal fixator constructs

2015 ◽  
Vol 28 (04) ◽  
pp. 227-233 ◽  
Author(s):  
S. K. Tyagi ◽  
P. Kinjavdeka ◽  
Sharma Amarpal ◽  
A. M. Pawde ◽  
T. Srivastava ◽  
...  
Keyword(s):  
High Density Polyethylene ◽  
Bone Fractures ◽  
Testing Machine ◽  
Biomechanical Testing ◽  
Bending Moment ◽  
Biomechanical Properties ◽  
Clinical Situation ◽  
High Density ◽  
Significant Difference

SummaryObjective: To evaluate the in vitro biomechanical properties of four different configurations of acrylic external skeletal fixator constructs.Materials and methods: Simulated bone constructs were prepared using two segments of 20 mm ultra-high-density polyethylene rods with a gap of 5 mm. The full pins (1.5 mm) were passed through the proximal and distal segments of ultra-high-density polyethylene rods, in the same plane, parallel to each other in configuration U, and were crossed in the M1, M2 and C configurations at a 90° angle to each other. Configuration U was a single bilateral uniplanar construct, M1 was a double orthogonal bilateral construct, M2 was a double orthogonal bilateral construct with proximal and distal connecting articulations, and C was a double orthogonal bilateral construct with proximal and distal circumferential articulations. Temporary scaffolds of different external skeletal fixator configurations were constructed using commercially available polyvinyl chloride pipes (20 mm) connected and secured to the fixation pins at a fixed distance from the rods. Acrylic powder (polymer) mixed with liquid (monomer) was poured into the pipes and allowed to solidify to form the side bars and rings. The external skeletal fixator constructs were then subjected to axial compression, cranio-caudal three-point bending and torsion (n = 4 each) using a universal testing machine. Mechanical parameters, namely stress, strain, modulus of elasticity, stiffness and bending moment of fixator constructs, were determined from load-displacement curves.Results: Configuration U was the weakest and configuration C was the strongest under all the testing modes. Under compression, the M1, M2 and C configurations were similar. Under bending, a significant difference was observed among the uniplanar, multi -planar and circular configurations with no difference between M1 and M2. However, under torsion, all the external skeletal fixator configurations differed significantly.Clinical significance: The freeform external skeletal fixator using acrylic as a replacement for a metallic bar may be useful to treat bone fractures and luxations in small animals, as it is mechanically strong, lightweight, economical, and pins can be passed from any direction depending upon the clinical situation.

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