Mathematical Modeling of the Paired Electro‐organic Syntheses in Packed Bed Flow Reactors: I .2‐Butanone from 2,3‐Butanediol

1988 ◽  
Vol 135 (6) ◽  
pp. 1392-1400 ◽  
Author(s):  
Jimmy C. Yu ◽  
M. M. Baizer ◽  
Ken Nobe
Keyword(s):  
Mathematical Modeling ◽  
Packed Bed ◽  
Flow Reactors ◽  
Organic Syntheses

scholarly journals Towards a Novel Computer-Aided Optimization of Microreactors: Techno-Economic Evaluation of an Immobilized Enzyme System

Symmetry ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 524
Author(s):  
Philip Pietrek ◽  
Manfred Kraut ◽  
Roland Dittmeyer
Keyword(s):  
Magnetic Beads ◽  
Glucose Dehydrogenase ◽  
Packed Bed ◽  
Detailed Knowledge ◽  
Reaction Conditions ◽  
Flow Reactors ◽  
Continuous Flow Reactors ◽  
Enzyme Cascades ◽  
And Control ◽  
Physical And Chemical

Immobilized multi-enzyme cascades are increasingly used in microfluidic devices. In particular, their application in continuous flow reactors shows great potential, utilizing the benefits of reusability and control of the reaction conditions. However, capitalizing on this potential is challenging and requires detailed knowledge of the investigated system. Here, we show the application of computational methods for optimization with multi-level reactor design (MLRD) methodology based on the underlying physical and chemical processes. We optimize a stereoselective reduction of a diketone catalyzed by ketoreductase (Gre2) and Nicotinamidadenindinukleotidphosphat (NADPH) cofactor regeneration with glucose dehydrogenase (GDH). Both enzymes are separately immobilized on magnetic beads forming a packed bed within the microreactor. We derive optimal reactor feed concentrations and enzyme ratios for enhanced performance and a basic economic model in order to maximize the techno-economic performance (TEP) for the first reduction of 5-nitrononane-2,8-dione.

Mathematical modeling of Kluyveromyces marxianus growth in solid-state fermentation using a packed-bed bioreactor

2009 ◽  
Vol 37 (4) ◽  
pp. 391-400 ◽  
Author(s):  
Marcio A. Mazutti ◽  
Giovani Zabot ◽  
Gabriela Boni ◽  
Aline Skovronski ◽  
Débora de Oliveira ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Solid State ◽  
Solid State Fermentation ◽  
Kluyveromyces Marxianus ◽  
Packed Bed ◽  
Packed Bed Bioreactor

Mathematical modeling of packed bed and microwave drying of enriched couscous

2018 ◽  
Vol 12 (3) ◽  
pp. 1723-1733 ◽  
Author(s):  
Ayşe Nur Yüksel ◽  
Mehmet Durdu Oner ◽  
Mustafa Bayram ◽  
Manolya Eser Oner
Keyword(s):  
Mathematical Modeling ◽  
Packed Bed ◽  
Microwave Drying

scholarly journals Catalysis-in-a-Box: Robotic Screening of Catalytic Materials in the Time of COVID-19

2020 ◽  
Author(s):  
Gaurav Kumar ◽  
Hannah Bossert ◽  
Daniel McDonald ◽  
Anargyros Chatzidmitriou ◽  
M. Alexander Ardagh ◽  
...  
Keyword(s):  
Flow Reactor ◽  
Low Cost ◽  
Packed Bed ◽  
Reaction Rates ◽  
Laboratory Scale ◽  
Materials Testing ◽  
Kinetic Measurements ◽  
Flow Reactors ◽  
Activation Barriers ◽  
Micro Flow

<p></p><p>The emergence of a viral pandemic has motivated the transition away from traditional, labor-intensive materials testing techniques to new automated approaches without compromising on data quality and at costs viable for academic laboratories. Reported here is the design and implementation of an autonomous micro-flow reactor for catalyst evaluation condensing conventional laboratory-scale analogues within a single gas chromatograph (GC), enabling the control of relevant parameters including reactor temperature and reactant partial pressures directly from the GC. Inquiries into the hydrodynamic behavior, temperature control, and heat/mass transfer were sought to evaluate the efficacy of the micro-flow reactor for kinetic measurements. As a catalyst material screening example, a combination of four Brønsted acid catalyzed probe reactions, namely the dehydration of ethanol, 2-propanol, 1-butanol, and the dehydra-decyclization of 2-methyltetrahydrofuran on a solid acid HZSM-5 (Si/Al 140), were carried out in the temperature range 403-543 K for the measurement of apparent reaction kinetics. Product selectivities, proton-normalized reaction rates, and apparent activation barriers were in agreement with measurements performed on conventional packed bed flow reactors. Furthermore, the developed micro-flow reactor was demonstrated to be about ten-fold cheaper to fabricate than commercial automated laboratory-scale reactor setups and is intended to be used for kinetic investigations in vapor-phase catalytic chemistries, with the key benefits including automation, low cost, and limited experimental equipment instrumentation.</p><p></p>

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