MR Imaging Mapping of Skeletal Muscle Denervation in Entrapment and Compressive Neuropathies

Radiographics ◽  
2011 ◽  
Vol 31 (2) ◽  
pp. 319-332 ◽  
Author(s):  
Su-Jin Kim ◽  
Sung Hwan Hong ◽  
Woo Sun Jun ◽  
Ja-Young Choi ◽  
Jae Sung Myung ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mr Imaging ◽  
Muscle Denervation

The cell adhesion molecule M-cadherin is specifically expressed in developing and regenerating, but not denervated skeletal muscle

Development ◽  
1993 ◽  
Vol 117 (4) ◽  
pp. 1409-1420 ◽  
Author(s):  
R. Moore ◽  
F.S. Walsh
Keyword(s):  
Skeletal Muscle ◽  
Tissue Distribution ◽  
Cell Adhesion Molecule ◽  
Muscle Denervation ◽  
Regulatory Factor ◽  
Myogenic Regulatory Factor ◽  
Adult Skeletal Muscle ◽  
Specific Tissue ◽  
Alpha Actin

The spatiotemporal distribution of M-cadherin mRNA has been determined by in situ hybridization in the mouse embryo and in adult skeletal muscle following experimental regeneration and denervation. M-cadherin mRNA is highly tissue specific and is found only in developing skeletal muscle. In contrast, N-cadherin mRNA has a broader tissue distribution in the embryo, being found on both neural elements and skeletal and cardiac muscle. M-cadherin is expressed in the myotomes shortly after they form, along with the myogenic regulatory factor myogenin. M-cadherin is expressed in muscles derived from the myotomes and is detected in forelimb bud precursor cells at embryonic day 11.5. In the latter case M-cadherin expression appears co-ordinately with that of myogenin and cardiac alpha-actin. Shortly before birth, M-cadherin expression is down regulated. M-cadherin can, however, be re-expressed following experimental regeneration of skeletal muscle. Here M-cadherin is transiently expressed on regenerating myoblasts but not myotubes. Following muscle denervation no evidence was found for re-expression of M-cadherin under conditions where there was strong expression of the nicotinic acetylcholine receptor on myofibres. The highly specific tissue distribution and unique developmental profile distinguishes M-cadherin from other cadherins and suggests a role in cell surface events during early myogenesis.

Neural regulation of the enhanced uptake of glucose in skeletal muscle after endotoxin

1995 ◽  
Vol 269 (2) ◽  
pp. R437-R444 ◽  
Author(s):  
C. H. Lang
Keyword(s):  
Skeletal Muscle ◽  
Nerve Transection ◽  
Muscle Denervation ◽  
Denervated Muscle ◽  
Muscle Type ◽  
Euglycemic Hyperinsulinemic Clamp ◽  
Sciatic Nerve Transection ◽  
Insulin Levels ◽  
Stimulation Of

Previous studies have demonstrated that in vivo injection of lipopolysaccharide (LPS) acutely stimulates glucose uptake (GU) in skeletal muscle. The purpose of the present study was to determine whether this enhanced GU is neurally mediated. In the first group of rats, a unilateral sciatic nerve transection was performed 3 h before injection of LPS, and in vivo GU was assessed using 2-[14C]deoxy-D-glucose 40 min after LPS injection. At this time, LPS-treated rats were hyperglycemic (12 mM), and insulin levels were not different from control rats. In the innervated leg, LPS increased GU 43-228%, depending on the muscle type. In contrast, LPS failed to increase GU in muscles from the denervated limb. In other experiments, somatostatin was infused to produce an insulinopenic condition before the injection of LPS. Despite insulinopenia, muscle GU was still increased by LPS. In control rats, in which the euglycemic hyperinsulinemic clamp technique was used, acute muscle denervation was shown to impair insulin-mediated GU in the presence of pharmacological, but not physiological, insulin levels. Non-insulin-mediated GU (NIMGU) was assessed in rats that were insulinopenic and hyperglycemic. In innervated muscle, NIMGU was increased 56-126 and 118-145% when the plasma glucose was elevated to 9 and 12 mM, respectively. In contrast, hyperglycemia-induced increases in NIMGU were attenuated in denervated muscle. These data demonstrate that 1) the early LPS-induced stimulation of muscle GU is mediated via a non-insulin-mediated pathway and 2) the LPS-induced increase in NIMGU in muscle is neurally mediated.

Muscle denervation patterns in upper limb nerve injuries: MR imaging findings and anatomic basis.

1998 ◽  
Vol 171 (3) ◽  
pp. 779-784 ◽  
Author(s):  
D Sallomi ◽  
D L Janzen ◽  
P L Munk ◽  
D G Connell ◽  
P F Tirman
Keyword(s):  
Mr Imaging ◽  
Upper Limb ◽  
Imaging Findings ◽  
Muscle Denervation ◽  
Nerve Injuries ◽  
Anatomic Basis

scholarly journals Skeletal muscle denervation investigations: selecting an experimental control wisely

2019 ◽  
Vol 316 (3) ◽  
pp. C456-C461 ◽  
Author(s):  
Haiming Liu ◽  
LaDora V. Thompson
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Tibial Nerve ◽  
Nerve Transection ◽  
Muscle Denervation ◽  
Crossover Effect ◽  
Proteolytic System ◽  
Experimental Control ◽  
Denervated Muscles

Unilateral denervation is widely used for studies investigating mechanisms of muscle atrophy. The “contralateral-innervated muscle” is a commonly used experimental control in denervation studies. It is not clear whether denervation unilaterally alters the proteolytic system in the contralateral-innervated muscles. Therefore, the objectives of this rapid report are 1) to determine whether unilateral denervation has an effect on the proteolytic system in contralateral-innervated control muscles and 2) to identify the changes in proteasome properties in denervated muscles after 7- and 14-day tibial nerve transection with either the contralateral-innervated muscles or intact muscles from nonsurgical mice used as the experimental control. In the contralateral-innervated muscles after 7 and 14 days of nerve transection, the proteasome activities and content are significantly increased compared with muscles from nonsurgical mice. When the nonsurgical mice are used as the experimental control, a robust increase in proteasome properties is found in the denervated muscles. This robust increase in proteasome properties is eliminated when the contralateral-innervated muscles are the experimental control. In conclusion, there is a crossover effect from unilateral denervation on proteolytic parameters. As a result, the crossover effect on contralateral-innervated muscles must be considered when an experimental control is selected in a denervation study.

Skeletal muscle lymphoma: observations at MR imaging

1996 ◽  
Vol 25 (5) ◽  
pp. 425-430 ◽  
Author(s):  
S. Eustace ◽  
Carl S. Winalski ◽  
Archie McGowen ◽  
Howard Lan ◽  
David Dorfman
Keyword(s):  
Skeletal Muscle ◽  
Mr Imaging

Peripheral Nerve Injury: Diagnosis with MR Imaging of Denervated Skeletal Muscle—Experimental Study in Rats

Radiology ◽  
2008 ◽  
Vol 247 (2) ◽  
pp. 409-417 ◽  
Author(s):  
Eiko Yamabe ◽  
Toshiyasu Nakamura ◽  
Koichi Oshio ◽  
Yoshito Kikuchi ◽  
Hiroyasu Ikegami ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Experimental Study ◽  
Mr Imaging ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury

scholarly journals 7-Tesla Magnetic Resonance Imaging Precisely and Noninvasively Reflects Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Clara Sciorati ◽  
Antonio Esposito ◽  
Lara Campana ◽  
Tamara Canu ◽  
Antonella Monno ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Skeletal Muscle ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Mouse Model ◽  
Experimental Models ◽  
Inflammatory Myopathies ◽  
Antisynthetase Syndrome ◽  
Resonance Imaging ◽  
Amino Terminal

Inflammatory myopathies comprise heterogeneous disorders. Their etiopathogenesis is poorly understood, because of the paucity of informative experimental models and of approaches for the noninvasive study of inflamed tissues. Magnetic resonance imaging (MRI) provides information about the state of the skeletal muscle that reflects various facets of inflammation and remodeling. This technique has been scarcely used in experimental models of inflammatory myopathies. We characterized the performance of MRI in a well-established mouse model of myositis and the antisynthetase syndrome, based on the immunization of wild-type mice with the amino-terminal fragment of histidyl-tRNA synthetase (HisRS). Over an eight-week period following myositis induction, MRI enabled precise identification of pathological events taking place in muscle tissue. Areas of edema and of active inflammation identified by histopathology paralleled muscle modifications detected noninvasively by MRI. Muscles changes were chronologically associated with the establishment of autoimmunity, as reflected by the development of anti-HisRS antibodies in the blood of immunized mice. MR imaging easily appreciated muscle damage and remodeling even if actual disruption of myofiber integrity (as assessed by serum concentrations of creatinine phosphokinase) was limited. Thus, MR imaging represents an informative and noninvasive analytical tool for studyingin vivoimmune-mediated muscle involvement.

scholarly journals Modulation of the Neuregulin 1/ErbB system after skeletal muscle denervation and reinnervation

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Michela Morano ◽  
Giulia Ronchi ◽  
Valentina Nicolò ◽  
Benedetta Elena Fornasari ◽  
Alessandro Crosio ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Denervation ◽  
Neuregulin 1
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