scholarly journals Quantification of Bone Involvement in Gaucher Disease: MR Imaging Bone Marrow Burden Score as an Alternative to Dixon Quantitative Chemical Shift MR Imaging—Initial Experience

Radiology ◽  
2003 ◽  
Vol 229 (2) ◽  
pp. 554-561 ◽  
Author(s):  
Mario Maas ◽  
Cornelis van Kuijk ◽  
Jaap Stoker ◽  
Carla E. M. Hollak ◽  
Erik M. Akkerman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chemical Shift ◽  
Mr Imaging ◽  
Gaucher Disease ◽  
Bone Involvement ◽  
Initial Experience ◽  
Quantitative Chemical

Quantitative chemical shift imaging of vertebral bone marrow in patients with Gaucher disease.

Radiology ◽  
1992 ◽  
Vol 182 (2) ◽  
pp. 451-455 ◽  
Author(s):  
L A Johnson ◽  
B E Hoppel ◽  
E L Gerard ◽  
S P Miller ◽  
S H Doppelt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chemical Shift ◽  
Gaucher Disease ◽  
Chemical Shift Imaging ◽  
Vertebral Bone ◽  
Vertebral Bone Marrow ◽  
Quantitative Chemical

QCSI (quantitative chemical shift imaging) for assessment of bone marrow involvement in patients with Gaucher disease

2018 ◽  
Vol 123 (2) ◽  
pp. S153
Author(s):  
Ari Zimran ◽  
Michal Becker-Cohen ◽  
Shoshana Revel-Vilk ◽  
Mario Maas ◽  
Tama Dinor ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chemical Shift ◽  
Gaucher Disease ◽  
Bone Marrow Involvement ◽  
Chemical Shift Imaging ◽  
Quantitative Chemical

Hematologic bone marrow disorders: quantitative chemical shift MR imaging.

Radiology ◽  
1988 ◽  
Vol 169 (3) ◽  
pp. 799-804 ◽  
Author(s):  
B R Rosen ◽  
D M Fleming ◽  
D C Kushner ◽  
K S Zaner ◽  
R B Buxton ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chemical Shift ◽  
Mr Imaging ◽  
Bone Marrow Disorders ◽  
Quantitative Chemical

Enzyme Replacement Therapy for Gaucher Disease: Skeletal Responses to Macrophage-targeted Glucocerebrosidase

PEDIATRICS ◽  
1995 ◽  
Vol 96 (4) ◽  
pp. 629-637
Author(s):  
Daniel I. Rosenthal ◽  
Samuel H. Doppelt ◽  
Henry J. Mankin ◽  
James M. Dambrosia ◽  
Ramnik J. Xavier ◽  
...  
Keyword(s):  
Body Weight ◽  
Chemical Shift ◽  
Bone Mass ◽  
Enzyme Replacement Therapy ◽  
Replacement Therapy ◽  
Gaucher Disease ◽  
Chemical Shift Imaging ◽  
Prolonged Treatment ◽  
Enzyme Replacement ◽  
Quantitative Chemical

Objectives. Reversal of the hematologic and visceral abnormalities characteristic of Gaucher disease, the most common lipid storage disorder, with biweekly infusions of macrophage-targeted glucocerebrosidase (glucosylceramidase) is well documented. The extent to which the skeleton responds to enzyme replacement therapy has not been systematically investigated. Methods. To assess the skeletal response to enzyme replacement therapy, we treated 12 patients with type 1 Gaucher disease, who had intact spleens, with macrophage-targeted glucocerebrosidase. The initial dose of enzyme was 60 U/kg body weight every 2 weeks for 24 months, followed by reduction in dosage to 30 and then 15 U/kg body weight every 2 weeks, each for 9 months. Results. The lipid composition of bone marrow, determined by direct chemical analysis, began to improve after 6 months of treatment at a time when noninvasive imaging studies showed no significant changes. By 42 months, improvement in marrow composition was demonstrable on all noninvasive, quantitative imaging modalities (magnetic resonance score, quantitative xenon scintigraphy, and quantitative chemical shift imaging) used in this study. Quantitative chemical shift imaging, the most sensitive technique, demonstrated a dramatic normalization of the marrow fat content in all patients. Net increases in either cortical or trabecular bone mass, as assessed by combined cortical thickness measurements and dual-energy quantitative computed tomography, respectively, occurred in 10 patients. Conclusions. Prolonged treatment over 3½ years with macrophage-targeted glucocerebrosidase produces objective reversal of disease in both the axial and appendicular skeleton in patients with Gaucher disease. Marked improvement occurs in marrow composition and bone mass in both children and adults.

Assessment of Bone Marrow Angiogenesis in Patients with Acute Myeloid Leukemia by Using Contrast-enhanced MR Imaging with Clinically Approved Iron Oxides: Initial Experience

Radiology ◽  
2007 ◽  
Vol 242 (1) ◽  
pp. 217-224 ◽  
Author(s):  
Lars Matuszewski ◽  
Thorsten Persigehl ◽  
Alexander Wall ◽  
Norbert Meier ◽  
Ralf Bieker ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Mr Imaging ◽  
Iron Oxides ◽  
Myeloid Leukemia ◽  
Initial Experience ◽  
Contrast Enhanced ◽  
Acute Myeloid

Evaluation of an imaging biomarker, Dixon quantitative chemical shift imaging, in Gaucher disease: lessons learned

2014 ◽  
Vol 37 (6) ◽  
pp. 1003-1011 ◽  
Author(s):  
L. van Dussen ◽  
E. M. Akkerman ◽  
C. E. M. Hollak ◽  
A. J. Nederveen ◽  
M. Maas
Keyword(s):  
Chemical Shift ◽  
Gaucher Disease ◽  
Chemical Shift Imaging ◽  
Lessons Learned ◽  
Imaging Biomarker ◽  
Quantitative Chemical
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