Coronary High-Intensity Plaques at T1-weighted MRI in Stable Coronary Artery Disease: Comparison with Near-Infrared Spectroscopy Intravascular US

Radiology ◽  
2021 ◽  
Author(s):  
Shunya Sato ◽  
Hidenari Matsumoto ◽  
Debiao Li ◽  
Hidefumi Ohya ◽  
Hiroyoshi Mori ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Infrared Spectroscopy ◽  
Coronary Artery ◽  
Near Infrared Spectroscopy ◽  
High Intensity ◽  
Near Infrared ◽  
Stable Coronary Artery Disease ◽  
Artery Disease

scholarly journals Intracoronary near-infrared spectroscopy and the risk of future cardiovascular events

Open Heart ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. e000917 ◽  
Author(s):  
Sofia Karlsson ◽  
Erik Anesäter ◽  
Klara Fransson ◽  
Pontus Andell ◽  
Jonas Persson ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Infrared Spectroscopy ◽  
Coronary Artery ◽  
Near Infrared Spectroscopy ◽  
Cardiovascular Events ◽  
Roc Analysis ◽  
Near Infrared ◽  
Plaque Burden ◽  
Cerebrovascular Events ◽  
Artery Disease

ObjectivesThe objectives of this study were to investigate if findings by intracoronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) are associated with future cardiovascular events and if NIRS can differentiate culprit from non-culprit segments in patients with coronary artery disease.MethodsThe study included 144 patients with coronary artery disease undergoing percutaneous coronary intervention and combined NIRS-IVUS imaging at two Swedish hospitals. The NIRS-derived lipid core burden index (LCBI), the 4 mm segment with maximum LCBI (MaxLCBI4mm) and the IVUS-derived maximum plaque burden (MaxPB) were analysed within the culprit segment and continuous 10 mm non-culprit segments of the index culprit vessels. The association with future major adverse cardiovascular and cerebrovascular events (MACCE), defined as all-cause mortality, acute coronary syndrome requiring revascularisation and cerebrovascular events during follow-up was evaluated using multivariable Cox regressions. A receiver operating characteristic (ROC) analysis was performed to test the ability of NIRS to discriminate culprit against non-culprit segments.ResultsA non-culprit maxLCBI4mm ≥400 (HR: 3.67, 95% CI 1.46 to 9.23, p=0.006) and a non-culprit LCBI ≥ median (HR: 3.08, 95% CI 1.11 to 8.56, p=0.031) were both significantly associated with MACCE, whereas a non-culprit MaxPB ≥70% (HR: 0.61, 95% CI 0.08 to 4.59, p=0.63) was not. The culprit segments had larger lipid cores compared with non-culprit segments (MaxLCBI4mm 425 vs 74, p<0.001), and the ROC analysis showed that NIRS can differentiate culprit against non-culprit segments (c-statistics: 0.85, 95% CI 0.81 to 0.89).ConclusionA maxLCBI4mm ≥400 and LCBI ≥ median, assessed by NIRS in non-culprit segments of a culprit artery, were significantly associated with patient-level MACCE. NIRS furthermore adequately discriminated culprit against non-culprit segments in patients with coronary disease.

Sign in / Sign up

Export Citation Format

Share Document