scholarly journals Influence of Parathyroidectomy on Bone Calcium Concentration: Evaluation with Spectral CT in Patients with Secondary Hyperparathyroidism Undergoing Hemodialysis—A Prospective Feasibility Study

Radiology ◽  
2017 ◽  
Vol 284 (1) ◽  
pp. 143-152 ◽  
Author(s):  
Qiang Ma ◽  
Zhenghan Yang ◽  
Xue Han ◽  
Fen Liu ◽  
Dechun Su ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Feasibility Study ◽  
Calcium Concentration ◽  
Spectral Ct ◽  
Bone Calcium

scholarly journals Co-Treatment of Purified Annatto Oil (Bixa orellana L.) and Its Granules (Chronic®) Improves the Blood Lipid Profile and Bone Protective Effects of Testosterone in the Orchiectomy-Induced Osteoporosis in Wistar Rats

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4720
Author(s):  
Arlindo César Matias Pereira ◽  
Helison de Oliveira Carvalho ◽  
Danna Emanuelle Santos Gonçalves ◽  
Karyny Roberta Tavares Picanço ◽  
Abrahão Victor Tavares de Lima Teixeira dos dos Santos ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Calcium Concentration ◽  
Calcium Content ◽  
Blood Lipid ◽  
Atomic Absorption Spectrophotometry ◽  
Protective Effects ◽  
Blood Lipid Profile ◽  
Bone Calcium ◽  
Weight Structure

This study aimed to evaluate and compare the effects of co-treatment with purified annatto oil (PAO) or its granules (GRA, Chronic®) with that of testosterone on the orchiectomy-induced osteoporosis in Wistar rats. After surgery, rats were treated from day 7 until day 45 with testosterone only (TES, 7 mg/kg, IM) or TES + PAO or GRA (200 mg/kg, p.o.). The following parameters were evaluated: food/water intake, weight, HDL, LDL, glucose, triglycerides (TG), total cholesterol (TC), alkaline phosphatase levels, blood phosphorus and calcium contents, femur weight, structure (through scanning electron microscopy), and calcium content (through atomic absorption spectrophotometry). Our results show that orchiectomy could significantly change the blood lipid profile and decrease bone integrity parameters. Testosterone reposition alone could improve some endpoints, including LDL, TC, bone weight, and bone calcium concentration. However, other parameters were not significantly improved. Co-treatment with PAO or GRA improved the blood lipid profile and bone integrity more significantly and improved some endpoints not affected by testosterone reposition alone (such as TG levels and trabeculae sizes). The results suggest that co-treatment with annatto products improved the blood lipid profile and the anti-osteoporosis effects of testosterone. Overall, GRA had better results than PAO.

TU-EF-204-04: Feasibility Study of a Novel Stationary Spectral CT Scanner

2015 ◽  
Vol 42 (6Part34) ◽  
pp. 3620-3621
Author(s):  
P Xu ◽  
X Xing ◽  
J Zheng ◽  
S Chen ◽  
Y Zhang ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Ct Scanner ◽  
Spectral Ct

Differential diagnosis of hepatic cancerous nodules and cirrhosis nodules by spectral CT imaging: a feasibility study

2019 ◽  
Vol 60 (12) ◽  
pp. 1602-1608
Author(s):  
Lu Gao ◽  
Yi Lv ◽  
Yingying Jin ◽  
Fang Han ◽  
Zhenwei Yao ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Feasibility Study ◽  
Ct Imaging ◽  
Spectral Ct

scholarly journals Efficacy and safety of microwave ablation for ectopic secondary hyperparathyroidism: a feasibility study

2019 ◽  
Vol 36 (1) ◽  
pp. 646-652 ◽  
Author(s):  
Xin Li ◽  
Ying Wei ◽  
Hongzeng Shao ◽  
Lili Peng ◽  
Chao An ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Feasibility Study ◽  
Microwave Ablation ◽  
Efficacy And Safety

scholarly journals High phosphate level directly stimulates parathyroid hormone secretion and synthesis by human parathyroid tissue in vitro.

1998 ◽  
Vol 9 (10) ◽  
pp. 1845-1852
Author(s):  
Y Almaden ◽  
A Hernandez ◽  
V Torregrosa ◽  
A Canalejo ◽  
L Sabate ◽  
...  
Keyword(s):  
Secondary Hyperparathyroidism ◽  
Calcium Concentration ◽  
Statistical Significance ◽  
Hormone Secretion ◽  
Parathyroid Tissue ◽  
Parathyroid Glands ◽  
Mrna Levels ◽  
High Calcium ◽  
High Phosphate

Phosphate retention plays an important role in the pathogenesis of secondary hyperparathyroidism in patients with renal failure. In in vitro studies, high extracellular phosphate levels directly stimulate PTH secretion in rat and bovine parathyroid tissue. The present study evaluates the effect of high phosphate levels on the secretion of PTH and the production of prepro PTH mRNA in human hyperplastic parathyroid glands. The study includes parathyroid glands obtained from patients with primary adenomas and from hemodialysis and kidney-transplant patients with diffuse and nodular secondary hyperplasia. The experiments were performed in vitro using small pieces of parathyroid tissue. The ability of high calcium levels to decrease PTH secretion was less in adenomas than in secondary hyperplasia; among the secondary hyperplasia, nodular was less responsive to an increase in calcium than diffuse hyperplasia. In diffuse hyperplasia, PTH secretion was increased in response to 3 and 4 mM phosphate compared with 2 mM phosphate, despite a high calcium concentration in the medium; prepro PTH mRNA levels increased after incubation in 4 mM phosphate. Similar results were obtained with nodular hyperplasia, except that the elevation of PTH secretion in response to 3 mM phosphate did not attain statistical significance. In adenomas, high calcium concentrations (1.5 mM) did not result in inhibition of PTH secretion, independent of the phosphate concentration, and the prepro PTH mRNA was not significantly increased by high phosphate levels. In conclusion, first, the PTH secretory response to an increase in calcium concentration is less in nodular than diffuse hyperplasia; second, high phosphate levels directly affect PTH secretion and gene expression in patients with advanced secondary hyperparathyroidism.

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