scholarly journals US Cannot Be Used to Predict the Presence or Severity of Hepatic Steatosis in Severely Obese Adolescents

Radiology ◽  
2012 ◽  
Vol 262 (1) ◽  
pp. 327-334 ◽  
Author(s):  
Anneloes E. Bohte ◽  
Bart G. P. Koot ◽  
Olga H. van der Baan-Slootweg ◽  
Tammo H. Pels Rijcken ◽  
Jochem R. van Werven ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Obese Adolescents ◽  
Severely Obese

Acetaminophen pharmacokinetics in severely obese adolescents and young adults

2018 ◽  
Vol 29 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Mohammed Hakim ◽  
Brian J. Anderson ◽  
Hina Walia ◽  
Dmitry Tumin ◽  
Marc P. Michalsky ◽  
...  
Keyword(s):  
Young Adults ◽  
Adolescents And Young Adults ◽  
Obese Adolescents ◽  
Severely Obese

Bariatric surgery in severely obese adolescents: a single-centre experience

2014 ◽  
Vol 99 (10) ◽  
pp. 894-898 ◽  
Author(s):  
P. Sachdev ◽  
T. Makaya ◽  
S. S. Marven ◽  
R. Ackroyd ◽  
J. K. Wales ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Single Centre ◽  
Obese Adolescents ◽  
Single Centre Experience ◽  
Severely Obese

Leg arterial stiffness after weight loss in severely obese adolescents

2013 ◽  
Vol 168 (2) ◽  
pp. 1676-1677 ◽  
Author(s):  
David Montero ◽  
Guillaume Walther ◽  
Antonia Perez-Martin ◽  
Charles S. Mercier ◽  
Enrique Roche ◽  
...  
Keyword(s):  
Weight Loss ◽  
Arterial Stiffness ◽  
Obese Adolescents ◽  
Severely Obese

scholarly journals Laparoscopic sleeve gastrectomy in severely obese adolescents: effects on metabolic profile

2017 ◽  
Vol 61 (6) ◽  
pp. 608-613 ◽  
Author(s):  
Ruth Rocha Franco ◽  
Marina Ybarra ◽  
Louise Cominato ◽  
Larissa Mattar ◽  
Leandra Steinmetz ◽  
...  
Keyword(s):  
Sleeve Gastrectomy ◽  
Laparoscopic Sleeve Gastrectomy ◽  
Metabolic Profile ◽  
Obese Adolescents ◽  
Severely Obese

Abstract P080: Fructose Acutely Increases Size of Very Low Density Lipoprotein In Adolescents With Hepatic Steatosis

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Mirian Vos ◽  
Ran Jin ◽  
Jean Welsh ◽  
Ngoc-Anh Le
Keyword(s):  
Hepatic Steatosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cardiovascular Complications ◽  
Plasma Lipoproteins ◽  
Healthy Children ◽  
Mri Imaging ◽  
Nonalcoholic Fatty Liver ◽  
Obese Adolescents ◽  
Acute Response

Introduction: Cardiovascular complications are a leading cause of mortality in nonalcoholic fatty liver disease (NAFLD). Fructose has been reported to be associated with dyslipidemia and increased cardiovascular risk in adults but its impact on adolescents with NAFLD is not well understood. We previously demonstrated that fructose disproportionately increased postprandial hypertriglyceridemia in pediatric NAFLD as compared to healthy children. However, the mechanism remains unclear. Hypothesis: We hypothesized that fructose would contribute to hypertriglyceridemia in pediatric NAFLD by increasing the size of VLDL particles. Methods: We examined the acute response to a single dose of fructose beverage in 50 Hispanic-American obese adolescents with varying degrees of hepatic steatosis. Those with hepatic fat >5% on MRI imaging were designated as presumed NAFLD. Subjects consumed a 12oz drink containing 33g of fructose and plasma samples were collected at baseline and 30, 60, and 90 minutes afterwards. Plasma lipoproteins were measured using NMR (Liposcience, Raleigh, NC). Results: In response to acute fructose load, subjects without NAFLD increased the total number of TG rich lipoprotein particles (p = 0.047). However, this increase was not observed in subjects with NAFLD; instead, they increased the subpopulation of large VLDL particles (p = 0.008) and the mean size of VLDL particles (p = 0.004) (Figure 1). In line with this finding, TG-to-apoB ratio significantly increased in subjects with NAFLD (2.25 ± 0.26 to 2.37 ± 0.25, p = 0.031) but not in non-NAFLD. Conclusions: These findings demonstrate that adolescents with NAFLD have more atherogenic, large VLDL in response to fructose compared to obese adolescents without NAFLD. Dietary fructose restriction may be a critical component in the treatment of NAFLD associated cardiovascular disease and should be tested further.

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