scholarly journals Quantitative Analysis of Clinical Dynamic Contrast-enhanced MR Imaging for Evaluating Treatment Response in Human Breast Cancer

Radiology ◽  
2010 ◽  
Vol 257 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Yanming Yu ◽  
Quan Jiang ◽  
Yanwei Miao ◽  
Jun Li ◽  
Shanglian Bao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quantitative Analysis ◽  
Mr Imaging ◽  
Treatment Response ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

New Intravascular Contrast Agent Applied to Dynamic Contrast Enhanced Mr imaging of Human Breast Cancer

2003 ◽  
Vol 44 (3) ◽  
pp. 275-283 ◽  
Author(s):  
J. Rydland ◽  
A. BjOrnerud ◽  
O. Haugen ◽  
G. Torheim ◽  
C. Torres ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Dynamic Contrast Enhanced ◽  
Intravascular Contrast Agent ◽  
Contrast Enhanced

New intravascular contrast agent applied to dynamic contrast enhanced MR imaging of human breast cancer

2003 ◽  
Vol 44 (3) ◽  
pp. 275-283 ◽  
Author(s):  
J. Rydland ◽  
A. Bjørnerud ◽  
O. Haugen ◽  
G. Torheim ◽  
C. Torres ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Human Breast Cancer ◽  
Hot Spot ◽  
Human Breast ◽  
Tumor Grading ◽  
Dynamic Contrast Enhanced ◽  
Intravascular Contrast Agent ◽  
Contrast Enhanced ◽  
Dynamic Mr

Purpose: To evaluate the feasibility of using dynamic contrast-enhanced MR imaging with a new intravascular contrast agent in grading human breast cancer. Material and Methods: 23 patients with 27 breast tumors (21 carcinomas and 6 fibroadenomas) were examined with dynamic MR imaging after administration of Clariscan, an iron oxide nanoparticle with large T1 relaxivity and a long plasma half life. A 3D T1-weighted gradient echo sequence with an acquisition time of 60 s was repeated at regular intervals of 3–5 min before and up to 1 h after injection of 2 mg/kg b.w. of Clariscan. The endothelial transfer constant, Kps, which reflects overall vascular permeability, and the fractional plasma volume, fPV, were estimated from time-intensity curves acquired from three separate regions of interest (ROIs): whole tumor, a permeability hot spot, and a blood volume hot spot. Kps and fPV were compared to the results of histologic tumor grading (Scarff-Bloom-Richardson, SBR) and microvascular density, MVD. Results: A statistically significant correlation between the MR-derived Kps parameters and the SBR score was obtained for the whole tumor ROI ( R = 0.70), and for the permeability hot spot ROIs ( R = 0.67). A correlation between fPV and SBR was detected for the blood volume hot spot ROIs ( R = 0.48). There was no statistically significant correlation between Kps or fPV with MVD. Conclusion: The results support the hypothesis that dynamic MR with the intravascular contrast agent Clariscan may be used for non-invasive tumor grading.

Quantitative analysis of neovascular permeability in glioma by dynamic contrast-enhanced MR imaging

2012 ◽  
Vol 19 (6) ◽  
pp. 820-823 ◽  
Author(s):  
Zhongzheng Jia ◽  
Daoying Geng ◽  
Tianwen Xie ◽  
Jiaoyan Zhang ◽  
Ying Liu
Keyword(s):  
Quantitative Analysis ◽  
Mr Imaging ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced
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