Acute Bilirubin Encephalopathy

2021 ◽  
Author(s):  
Foram Gala ◽  
Aditi Venkatesh, MBBS
Keyword(s):  
Bilirubin Encephalopathy

scholarly journals Risk factors for acute bilirubin encephalopathy on admission to two Myanmar national paediatric hospitals

2015 ◽  
Vol 1 (1) ◽  
Author(s):  
G. Arnolda ◽  
H. M. Nwe ◽  
D. Trevisanuto ◽  
A. A. Thin ◽  
A. A. Thein ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bilirubin Encephalopathy

scholarly journals Neonatal Severe Hyperbilirubinemia Online Registry in Jiangsu Province: protocol for a multicentre, prospective, open, observational cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e040797
Author(s):  
Qianqian Li ◽  
Xiaoyi Deng ◽  
Junmei Yan ◽  
Xiaofan Sun ◽  
Xiaoyue Dong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Jiangsu Province ◽  
Survival Status ◽  
Bilirubin Encephalopathy ◽  
Brainstem Response ◽  
Observational Cohort ◽  
Severe Hyperbilirubinemia

IntroductionSevere hyperbilirubinaemia in newborns can be easily complicated by acute bilirubin encephalopathy or even kernicterus, which could lead to neurological sequelae or death. However, there is no systematic study of the management of severe hyperbilirubinaemia in China. The Neonatal Severe Hyperbilirubinemia Online Registry study aims to investigate the management of jaundice before admission, risk factors and outcomes of severe hyperbilirubinaemia in a real-world setting in China.Methods and analysisThis is a prospective, multicentre, open, observational cohort study. From May 2020 to April 2023, more than 2000 patients with neonatal severe hyperbilirubinaemia from 13 tertiary hospitals in Jiangsu Province will join the study. Demographic data and treatment information will be collected from their clinical data. Management measures for jaundice before admission will be collected by the WeChat applet (called ‘Follow-up of jaundice’) after being provided by the patient’s guardian using a mobile phone. Follow-up data will include cranial MRI examination results, brainstem auditory-evoked potential or automatic auditory brainstem response, physical examination results and Griffiths Development Scales-Chinese at the corrected ages of 3–6 months and 1 and 2 years. Results and conclusions will be recorded using ‘Follow-up of jaundice.’ In-hospital outcomes, including severity of hyperbilirubinaemia (severe, extreme, hazardous), acute bilirubin encephalopathy (mild, moderate, severe) and survival status (death or survival), will be collected at discharge. Follow-up outcomes will include loss to follow-up, survival status and kernicterus (yes or no) at 2 years. The research will enhance our comprehensive knowledge of jaundice management before admission, risk factors and outcomes of severe hyperbilirubinaemia in China, which will ultimately help to reduce the incidence of neonatal severe hyperbilirubinaemia.Ethics and disseminationOur protocol has been approved by the Medical Ethics Committee of Nanjing Maternity and Child Health Care Hospital. We will present our findings at national conferences and peer-reviewed paediatrics journals.Trial registration numberNCT04251286.

Neonatal Jaundice Detection Using a Computer Vision System

Designs ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 63
Author(s):  
Warqaa Hashim ◽  
Ali Al-Naji ◽  
Izzat A. Al-Rayahi ◽  
Makram Alkhaled ◽  
Javaan Chahl
Keyword(s):  
Neonatal Jaundice ◽  
Vision System ◽  
Digital Camera ◽  
Treatment Method ◽  
Common Condition ◽  
Computer Vision System ◽  
Efficient Treatment ◽  
Bilirubin Encephalopathy ◽  
High Level

Jaundice or Hyperbilirubinemia is a very common condition that affects newborns in their first few weeks of life. The main cause of jaundice is the high level of the bilirubin substance in the blood. As bilirubin is toxic to brain cells, acute bilirubin encephalopathy can occur in cases of extreme jaundice. This condition can result in brain trauma and lead to kernicterus, which causes repetitive and uncontrolled movements, a permanent upward look, and hearing loss. Thus, a timely diagnosis and treatment can help in preventing long-term damage. In this paper, a developed system based on a digital camera was proposed to diagnose and treat jaundice in newborns. The system detects jaundice and determines if the neonate needs treatment based on the analysis obtained from the real-time captured images. The treatment was achieved by using an Arduino Uno microcontroller to drive phototherapy lighting, which has proven to be an efficient treatment method for jaundice. In addition, the proposed system has the ability to send the diagnostic results to the mobile phone of the care provider. The obtained results from 20 infants inside the intensive care unit showed that the proposed system was accurate in terms of detecting jaundice, easy to implement, and affordable.

scholarly journals Apnea in acute bilirubin encephalopathy

2014 ◽  
Vol 38 (7) ◽  
pp. 407-411 ◽  
Author(s):  
Sanjiv B. Amin ◽  
Vinod K. Bhutani ◽  
Jon F. Watchko
Keyword(s):  
Bilirubin Encephalopathy

Reversibility of acute intermediate phase bilirubin encephalopathy

2009 ◽  
Vol 98 (10) ◽  
pp. 1689-1694 ◽  
Author(s):  
Thor Willy Ruud Hansen ◽  
Lutz Nietsch ◽  
Elisabeth Norman ◽  
Jesper Vandborg Bjerre ◽  
Jean-Michel Hascoet ◽  
...  
Keyword(s):  
Intermediate Phase ◽  
Bilirubin Encephalopathy

scholarly journals UGT1A1-related Bilirubin Encephalopathy/Kernicterus in Adults

2021 ◽  
Vol 000 (000) ◽  
pp. 000-000
Author(s):  
Jie Bai ◽  
Lu Li ◽  
Hui Liu ◽  
Shuang Liu ◽  
Li Bai ◽  
...  
Keyword(s):  
Bilirubin Encephalopathy

scholarly journals A 6-Day-Old Newborn with Vomiting and Jaundice

2021 ◽  
Vol 6 ◽  
pp. 5-8
Author(s):  
Nkechi Okotcha ◽  
Abbie Biggers ◽  
Jonathan Martin ◽  
Raphael Mattamal
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Serum Bilirubin ◽  
Severe Form ◽  
Intestinal Malrotation ◽  
Term Neonates ◽  
Transcutaneous Bilirubin ◽  
Bilirubin Encephalopathy

Sixty percent of term neonates and 80% of preterms have jaundice within the first week of life. Jaundice can be pathologic or physiologic, indirect, or direct. Indirect jaundice can be neurotoxic at high levels. In its most severe form, this presents as acute bilirubin encephalopathy or kernicterus. Screening for jaundice using a transcutaneous bilirubin check or serum bilirubin has contributed tremendously to the reduction of kernicterus, which ranges from 0.5-1.3/100,000 births. Often, the etiology is easy to decipher. Otherwise, it may be complicated when there are several factors contributing. We present a case of a 6-day-old with jaundice and vomiting who was suffering from intestinal malrotation and a urinary tract infection.

scholarly journals Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates

2021 ◽  
Author(s):  
Yiyi Ding ◽  
Shuo Wang ◽  
Rui Guo ◽  
Aizhen Zhang ◽  
Yufang Zhu
Keyword(s):  
Logistic Regression ◽  
Blood Glucose ◽  
Odds Ratio ◽  
Exchange Transfusion ◽  
Binary Logistic Regression ◽  
P Value ◽  
Bilirubin Encephalopathy ◽  
Unbound Bilirubin ◽  
Independent Variable ◽  
The Relationship

Abstract BACKGROUND: Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to acute bilirubin encephalopathy in children who underwent exchange transfusion after adjusting for other covariates. METHODS: A total of 46 neonates who underwent exchange transfusion were involved in The First People's Hospital Of Changde City in China from 2016-1-1 to 2018-12-31. The target independent variable and the dependent variable were unbound bilirubin levels measured at baseline and acute bilirubin encephalopathy respectively. Covariates involved in this study included sex, age, birth weight, blood glucose, red blood cell, hemolysis, receive phototherapy before exchange transfusion. RESULTS: The average gestational age of 46 selected participants was 38.6 ± 1.3 weeks old, the average age was 146.5 ± 86.9 hours old, 52.17% of them were male. Result of fully-adjusted binary logistic regression showed unbound bilirubin levels were positively associated with risk of acute bilirubin encephalopathy after adjusting confounders (Odds ratio = 1.41, 95% confidence intervals 1.05-1.91, P value <0.05). CONCLUSION: Unbound bilirubin levels are associated with neonatal acute bilirubin encephalopathy. The mechanism of unbound bilirubin levels leading to neonatal acute bilirubin encephalopathy needs to be further explored.

Bilirubin encephalopathy: Changing concepts

1980 ◽  
Vol 2 (3) ◽  
pp. 219-227 ◽  
Author(s):  
Leonore Ballowitz
Keyword(s):  
Bilirubin Encephalopathy
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