Bilateral retinoblastoma

Faculty Opinions recommendation of Simultaneous bilateral ophthalmic artery chemosurgery for bilateral retinoblastoma (tandem therapy).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726397967.793544662 ◽

2018 ◽

Author(s):

Amy C Schefler

Keyword(s):

Ophthalmic Artery ◽

Bilateral Retinoblastoma ◽

Tandem Therapy

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Chemoreduction with topotecan and vincristine: Quantifying tumor response in bilateral retinoblastoma patients

Pediatric Blood & Cancer ◽

10.1002/pbc.28882 ◽

2021 ◽

Vol 68 (4) ◽

Author(s):

Benjamin A. King ◽

Natasha Sahr ◽

April Sykes ◽

Matthew W. Wilson ◽

Rachel C. Brennan

Keyword(s):

Tumor Response ◽

Bilateral Retinoblastoma

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Successful Treatment of Late Isolated Bone Metastasis in a Patient with Bilateral Retinoblastoma Using an Unconventional Method

Ocular Oncology and Pathology ◽

10.1159/000514620 ◽

2021 ◽

pp. 1-5

Author(s):

Deepthi Boddu ◽

Priyakumari Thankamony ◽

Reshma Prakasam ◽

Subin Sugath ◽

Aswin Kumar ◽

...

Keyword(s):

Treatment Approach ◽

Treatment Modalities ◽

Complete Regression ◽

Aggressive Treatment ◽

Second Malignancies ◽

Transpupillary Thermotherapy ◽

Metastatic Recurrence ◽

Bilateral Retinoblastoma ◽

Unconventional Method

Though survival in bilateral retinoblastoma (RB) has improved due to advancement in diagnostics and treatment modalities, children require long-term follow-ups for recurrence and second malignancies. We report a case of bilateral RB in a 7-month-old baby who was treated with chemotherapy, transpupillary thermotherapy, and periocular carboplatin for both eyes following which there was complete regression of tumour. Six and a half years after treatment, the child presented with metastatic recurrence of tumour in the left ulna. He was treated successfully with chemotherapy, extracorporeal radiation and reimplantation therapy. A less aggressive treatment approach for isolated bone relapse may be considered in selected cases.

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Trilateral Retinoblastoma: Ectopic Intracranial Retinoblastoma Associated with Bilateral Retinoblastoma

Journal of Pediatric Ophthalmology & Strabismus ◽

10.3928/0191-3913-19821101-10 ◽

1982 ◽

Vol 19 (6) ◽

pp. 320-325

Author(s):

Lorenz E Zimmerman ◽

Robert P Burns ◽

Gerald Wankum ◽

Richard Tully ◽

James A Esterly

Keyword(s):

Bilateral Retinoblastoma ◽

Trilateral Retinoblastoma

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Trilateral retinoblastoma: ocular and pineal retinoblastomas

Journal of Neurosurgery ◽

10.3171/jns.1985.63.3.0367 ◽

1985 ◽

Vol 63 (3) ◽

pp. 367-370 ◽

Cited By ~ 25

Author(s):

Dennis L. Johnson ◽

Roma Chandra ◽

Wink S. Fisher ◽

M. Kathryn Hammock ◽

Craig A. McKeown

Keyword(s):

Host Resistance ◽

Early Mortality ◽

Early Age ◽

Pineal Tumor ◽

Multicentric Occurrence ◽

Content Type ◽

Aggressive Management ◽

Bilateral Retinoblastoma ◽

Trilateral Retinoblastoma ◽

Germinal Mutation

✓ Trilateral retinoblastomas, the syndrome of bilateral retinoblastoma associated with ectopic retinoblastoma in the pineal gland, is rare but well recognized. In contrast to bilateral retinoblastomas alone, the ocular retinoblastomas in trilateral retinoblastoma develop before the age of 6 months, and a family history positive for retinoblastoma is usually obtained. The retinal tumors are often quiescent at the time that the pineal tumor is discovered, and show no evidence of metastatic spread after enucleation of the globes. Pathologically, the pineal tumor is indistinguishable from the ocular retinoblastoma. The pathophysiology of this syndrome is not well understood, but a germinal mutation is thought to target photoreceptor tissue for further postzygotic mutation. Eventual expression depends on the inherited host resistance to the carcinogenic manifestation of these genes. The low host resistance of trilateral retinoblastoma is evident by the early age of presentation, the multicentric occurrence of the tumor, and the high early mortality rate despite aggressive management.

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