Multifocal Glioblastoma

2020 ◽  
Author(s):  
Nader Zakhari, MD, FRCPC
Keyword(s):  
Multifocal Glioblastoma

scholarly journals Multifocal glioblastoma multiform with “encephalitis-like presentation” : a case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Issam Sa’adeh ◽  
Mohamed Jamal Saadh
Keyword(s):  
Vasogenic Edema ◽  
Neurological Deficits ◽  
Herpes Simplex Virus 1 ◽  
Glioblastoma Multiform ◽  
Atypical Clinical Presentation ◽  
Mri Scans ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri ◽  
Simplex Virus ◽  
Multifocal Glioblastoma

Abstract Background Glioblastoma multiform is the most common and aggressive type of primary malignant tumor that affects the central nervous system in adults. It clinically presents with seizures, headache, and/or progressive focal neurological deficits. Radiologically, glioblastoma multiform appears as a single distinguishable, large heterogeneous lesion affecting the cerebrum with characteristic central necrosis, marginal enhancement, and surrounding vasogenic edema. This article describes a patient that exhibited an atypical clinical presentation of multifocal glioblastoma multiform with misleading early radiological features that simulated herpetic encephalitis. Results A 66-year-old female that presented with left-sided hemiparesis and left partial motor seizures underwent multi-slice computed tomography (MSCT) and magnetic resonance imaging (MRI) scans. A cerebrospinal fluid (CSF) polymerase chain reaction (PCR) test was also performed to screen for herpes simplex virus 1 (HSV-1). Conclusions The early stages of glioblastoma may manifest as symptoms typical to encephalitis, which can delay diagnosis and treatment. Therefore, early diagnosis and identification of atypical glioblastoma multiform presentations, as reported in this article, are essential.

scholarly journals Survival and recurrence patterns of multifocal glioblastoma after radiation therapy

2018 ◽  
Vol Volume 10 ◽  
pp. 4229-4235 ◽  
Author(s):  
Mustafa Syed ◽  
Jakob Liermann ◽  
Vivek Verma ◽  
Denise Bernhardt ◽  
Nina Bougatf ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Recurrence Patterns ◽  
Multifocal Glioblastoma

Multifocal Glioblastoma Multiforme: Prognostic Factors and Patterns of Progression

2007 ◽  
Vol 69 (3) ◽  
pp. 820-824 ◽  
Author(s):  
Timothy N. Showalter ◽  
Jocelyn Andrel ◽  
David W. Andrews ◽  
Walter J. Curran ◽  
Constantine Daskalakis ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Glioblastoma Multiforme ◽  
Multifocal Glioblastoma

CRITERIA FOR CHOOSING THE OPTIMAL DELIVERY STRATEGY FOR PATIENTS WITH NERVOUS SYSTEM PATHOLOGY

2021 ◽  
Vol 2 (1) ◽  
pp. 39-41
Author(s):  
Simonenko A.Yu.
Keyword(s):  
Multiple Sclerosis ◽  
Traumatic Brain Injury ◽  
Nervous System ◽  
Herniated Disc ◽  
Operative Delivery ◽  
Birth Canal ◽  
Natural Birth ◽  
Perinatal Center ◽  
History Of ◽  
Multifocal Glioblastoma

48 birth histories of patients in the Perinatal center of the V. D. Seredavin SOKB with various diseases of the nervous system were analyzed. 27 patients had planned delivery by caesarean section, due to the combination of relative indications from the fetus and a burdened obstetric history, and 21 – delivery through the natural birth canal. Delivery via the natural birth canal was performed in women with epilepsy-in 28% of patients with neurocirculatory dystonia: - in 16%, with encephalopathy-in 12%, with a herniated disc: - in 12%, with a history of traumatic brain injury-in 12%, with dorsopathy-in 12%, with multiple sclerosis-in 8%, with lumboishalgia-in 4%, with multifocal glioblastoma – 4%. 48% of newborns in women after delivery through the natural birth canal were completely healthy, only 11% had signs of cerebral ischemia, and 19% had slightly pronounced hypoxic and hypotrophic changes. Joint observation of such women during pregnancy by an obstetrician-gynecologist and a neurologist with rational pre-test training allowed to avoid operative delivery.

Resection versus biopsy in the treatment of multifocal glioblastoma: a weighted survival analysis

2020 ◽  
Vol 148 (1) ◽  
pp. 155-164 ◽  
Author(s):  
Long Di ◽  
Rainya N. Heath ◽  
Ashish H. Shah ◽  
Alexander D. Sanjurjo ◽  
Daniel G. Eichberg ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Multifocal Glioblastoma

scholarly journals Phase II trial of upfront bevacizumab and temozolomide for unresectable or multifocal glioblastoma

2013 ◽  
Vol 2 (2) ◽  
pp. 185-195 ◽  
Author(s):  
Emil Lou ◽  
Katherine B. Peters ◽  
Ashley L. Sumrall ◽  
Annick Desjardins ◽  
David A. Reardon ◽  
...  
Keyword(s):  
Phase Ii ◽  
Phase Ii Trial ◽  
Multifocal Glioblastoma

scholarly journals Comprehensive molecular characterization of multifocal glioblastoma proves its monoclonal origin and reveals novel insights into clonal evolution and heterogeneity of glioblastomas

2017 ◽  
Vol 19 (4) ◽  
pp. 546-557 ◽  
Author(s):  
Khalil Abou-El-Ardat ◽  
Michael Seifert ◽  
Kerstin Becker ◽  
Sophie Eisenreich ◽  
Matthias Lehmann ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Clonal Evolution ◽  
Multifocal Glioblastoma

scholarly journals MULTIFOCAL GLIOBLASTOMA MULTIFORME PRECEDED BY A GEMISTOCYTIC ASTROCYTOMA AND DYSREGULATED IMMUNE RESPONSE

2014 ◽  
Vol 20 (2) ◽  
pp. 502-505
Author(s):  
Ilian Koev ◽  
Emil Slavov ◽  
Hristo Zhelyazkov ◽  
Dmitrii Staikov ◽  
Krasimira Halacheva ◽  
...  
Keyword(s):  
Immune Response ◽  
Glioblastoma Multiforme ◽  
Gemistocytic Astrocytoma ◽  
Multifocal Glioblastoma

scholarly journals Diverse imaging features of adolescent glioblastoma: a case report

2021 ◽  
Author(s):  
Thomas Campion ◽  
Sara Stoneham ◽  
Ayisha Al-Busaidi ◽  
Atul Kumar ◽  
Zane Jaunmuktane ◽  
...  
Keyword(s):  
Case Report ◽  
Unusual Case ◽  
Brain Lesions ◽  
Imaging Features ◽  
Adolescent Patient ◽  
Treatment Delays ◽  
Multifocal Glioblastoma

We highlight an unusual case of multifocal glioblastoma in an adolescent patient, manifesting as four discrete brain lesions, each distinct in appearance. Familiarity with the diverse imaging features of glioblastoma can reduce misdiagnosis and avoid treatment delays.

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