Interstitial Edematous Pancreatitis

2020 ◽  
Author(s):  
Jahinover Mazo ◽  
Paoulina Ivanova ◽  
Yuliya Mazo ◽  
Zohaib Khan, BSc
Keyword(s):  
Edematous Pancreatitis

scholarly journals Necroptosis protects against exacerbation of acute pancreatitis

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Michittra Boonchan ◽  
Hideki Arimochi ◽  
Kunihiro Otsuka ◽  
Tomoko Kobayashi ◽  
Hisanori Uehara ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Necrotizing Pancreatitis ◽  
Neutrophil Infiltration ◽  
Dependent Manner ◽  
Protective Effects ◽  
Interacting Protein ◽  
Inflammatory Conditions ◽  
Edematous Pancreatitis ◽  
Genetic Deletion ◽  
Dose Dependent

AbstractThe sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of cell death and is involved in inflammatory conditions, the roles of necroptosis in acute pancreatitis (AP) remain unclear. In the current study, we administered caerulein to Ripk3- or Mlkl-deficient mice (Ripk3−/− or Mlkl−/− mice, respectively) and assessed the roles of necroptosis in AP. We found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice. Consistently, Mlkl−/− mice were more susceptible to caerulein-induced AP, which occurred in a time- and dose-dependent manner, than control mice. Mlkl−/− mice exhibit weight loss, edematous pancreatitis, necrotizing pancreatitis, and acinar cell dedifferentiation in response to tissue damage. Genetic deletion of Mlkl resulted in downregulation of the antiapoptotic genes Bclxl and Cflar in association with increases in the numbers of apoptotic cells, as detected by TUNEL assay. These findings suggest that RIPK3 and MLKL-mediated necroptosis exerts protective effects in AP and caution against the use of necroptosis inhibitors for AP treatment.

scholarly journals Dynamics of changes in the immune system and antioxidant protection in the treatment of acute pancreatitis

2019 ◽  
Vol 23 (1) ◽  
pp. 110-113
Author(s):  
K. E. Ishcheikin ◽  
V. V. Petrushenko ◽  
D. I. Grebeniuk ◽  
O. M. Zatserkovna ◽  
L. M. Malyk ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Immune System ◽  
Immune Status ◽  
Antioxidant Defense System ◽  
The State ◽  
Control Group ◽  
Comprehensive Treatment ◽  
Antioxidant Protection ◽  
Group I ◽  
Edematous Pancreatitis

The aim of the work was to study the dynamics of changes in the immune system indices and antioxidant protection when fluoroquinolones are included in the treatment regimen for acute edematous pancreatitis. The study included 86 patients with a diagnosis of acute edematous pancreatitis. Group I (n=40) consisted of patients who received treatment according to national and local standards and protocols, group II (n=46) — patients who additionally received fluoroquinolones as part of a comprehensive treatment. The control group consisted of 48 conditionally healthy people in whom laboratory and instrumental diagnostics were carried out similarly to those in patients with acute pancreatitis. According to the purpose and objectives of the study, the state of the immune system and the antioxidant defense system was studied. In patients with acute pancreatitis, changes in the indicators of the immune status were revealed, manifested by the formation of a secondary immunodeficiency with the addition of an autoimmune component. The traditional scheme of pharmacotherapy of acute pancreatitis without the use of antibiotics made it possible to partially correct the indicators of immune status. The use of ciprofloxacin in the complex pharmacotherapy of acute pancreatitis contributed to the normalization of the studied parameters. Thus, the use of fluoroquinolones in the complex pharmacotherapy of acute pancreatitis made it possible to effectively normalize the state of the immune system, cytokine and antioxidant statuses.

Interaction of complement and leukocytes in severe acute pancreatitis: potential for therapeutic intervention

2006 ◽  
Vol 291 (5) ◽  
pp. G844-G850 ◽  
Author(s):  
Werner Hartwig ◽  
Martina Klafs ◽  
Michael Kirschfink ◽  
Thilo Hackert ◽  
Lutz Schneider ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Complement Activation ◽  
Necrotizing Pancreatitis ◽  
Weight Ratio ◽  
Dry Weight ◽  
Organ Injury ◽  
Sham Operation ◽  
Midline Laparotomy ◽  
Complement Inhibition ◽  
Edematous Pancreatitis

In acute pancreatitis, local as well as systemic organ complications are mediated by the activation of various inflammatory cascades. The role of complement in this setting is unclear. The aim of the present study was to determine the level of complement activation in experimental pancreatitis, to evaluate the interaction of complement and leukocyte-endothelium activation, and to assess the effects of complement inhibition by soluble complement receptor 1 (sCR1) in this setting. Necrotizing pancreatitis was induced in Wistar rats by the combination of intravenous cerulein and retrograde infusion of glycodeoxycholic acid into the biliopancreatic duct; edematous pancreatitis was induced by intravenous cerulein only. In control animals, a sham operation (midline laparotomy) was performed. Complement activation, leukocyte sequestration, and pancreatic as well as pulmonary injury were assessed in the presence/absence of sCR1. Increased levels of C3a were found in necrotizing but not in edematous pancreatitis. When complement activation in necrotizing pancreatitis was blocked by sCR1, levels of C3a and total hemolytic activity (CH50) were decreased. Leukocyte-endothelial interaction, as assessed by intravital microscopy, and pancreatic as well as pulmonary organ injury (wet-to-dry weight ratio, MPO activity, and histology) were ameliorated by sCR1. As a result of the present study, necrotizing but not edematous pancreatitis is characterized by significant and early complement activation. Based on the interaction of complement and leukocytes, complement inhibition by sCR1 may be a valuable option in the treatment of leukocyte-associated organ injury in severe pancreatitis.

scholarly journals An Unexpected Result of Obesity Treatment: Orlistat-Related Acute Pancreatitis

2015 ◽  
Vol 9 (2) ◽  
pp. 152-155 ◽  
Author(s):  
Murat Kose ◽  
Samim Emet ◽  
Timur Selcuk Akpınar ◽  
Mehmet Ilhan ◽  
Ali Fuat Kaan Gok ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Elevated Serum ◽  
Interesting Case ◽  
Unexpected Result ◽  
Fat Tissue ◽  
Initial Stage ◽  
Tissue Edema ◽  
Edematous Pancreatitis ◽  
Prevalence Of Obesity ◽  
History Of

Orlistat is a pancreatic lipase inhibitor which is used to treat obesity. Due to the increasing prevalence of obesity, orlistat use is thought to rise progressively. We report an interesting case caused by orlistat use caught in the early stages of acute pancreatitis through imaging; in addition, the case had significantly elevated serum amylase levels. A 54-year-old male who had a history of orlistat treatment started 7 days before was admitted to the emergency department with complaints of abdominal pain, nausea and vomiting lasting for 24 h. Abdominal computed tomography revealed peripancreatic fat tissue edema and a heterogeneous appearance of the pancreas. Based on these findings, it was concluded that edematous pancreatitis was in its initial stage. Orlistat is a drug that is increasingly widespread use due to obesity. More attention must be paid when planning to prescribe orlistat to patients if there are risk factors for acute pancreatitis (alcohol use, height, serum calcium and lipid levels).

Alterations of systemic endotoxemia over the course of acute edematous pancreatitis

Pancreatology ◽  
2003 ◽  
Vol 3 (4) ◽  
pp. 323-328 ◽  
Author(s):  
Evangelos J. Giamarellos-Bourboulis ◽  
George C. Nikou ◽  
Maria Matsaggoura ◽  
Christos Toumpanakis ◽  
Paraskevi Grecka ◽  
...  
Keyword(s):  
Edematous Pancreatitis ◽  
Systemic Endotoxemia

scholarly journals A study of interventions and their outcome in the management of acute pancreatitis

2019 ◽  
Vol 6 (9) ◽  
pp. 3128
Author(s):  
Muppa Viswanath ◽  
Rakesh R. ◽  
Supreeth Kumar Reddy Kunnuru ◽  
Raghu Sri Charan Perubhotla ◽  
Mayank Kumar Gurjar ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Necrotizing Pancreatitis ◽  
Severity Index ◽  
Apache Ii ◽  
Special Treatment ◽  
Apache Ii Score ◽  
Severe Pancreatitis ◽  
Common Causes ◽  
Edematous Pancreatitis ◽  
Overall Mortality

Background: Acute pancreatitis is the most terrible of all the calamities that occur in connection with the abdominal viscera. The suddenness of its onset, the illimitable agony which accompanies it, and the mortality attendant upon it, all render it the most formidable of catastrophes. Aim of the study is to evaluate the treatment outcome in acute pancreatitis.Methods: All the patients who underwent surgery for chronic pancreatitis were included in the study. initial APACHE II score at admission and CT severity index was evaluated.Results: Edematous pancreatitis accounts for 80–90% of acute pancreatitis and remission can be achieved in most of the patients without receiving any special treatment. Necrotizing pancreatitis occupies 10–20% of acute pancreatitis and the mortality rate is reported to be 14-25%. Alcohol (45.8%) was the most common causes of acute severe pancreatitis in this study. Males were predominately affected (Male: Female = 29:5). Complication rate or morbidity is 50%. The initial APACHE II score at admission and CT severity index in the first scan were high in patients who underwent necrosectomy and the patients who died. The overall mortality in this study was 30.6%.Conclusions: In conclusion, one reason attributed to high mortality was due to the subgroup of patients who underwent PCD alone and failed to show any change in the recovery nor deterioration and lead to gross nutritional depletion and death, secondly those patients who underwent step up approach and ultimately needed surgery have more aggressive disease evidenced by high APACHE II score, CT severity index and % of necrosis.

Free fatty acids in serum of patients with acute necrotizing or edematous pancreatitis

1993 ◽  
Vol 13 (2) ◽  
pp. 105-110
Author(s):  
S. Domschke ◽  
P. Malfertheiner ◽  
W. Uhl ◽  
M. Büchler ◽  
W. Domschke
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Edematous Pancreatitis ◽  
Acute Necrotizing

Measurement of alpha-glucosidase activity in serum from patients with cystic fibrosis or pancreatitis.

1986 ◽  
Vol 32 (4) ◽  
pp. 652-656 ◽  
Author(s):  
W H Porter ◽  
C D Jennings ◽  
H D Wilson
Keyword(s):  
Pancreatic Cancer ◽  
Cystic Fibrosis ◽  
Clinical Course ◽  
Chronic Pulmonary Disease ◽  
Hospital Patient ◽  
Fluorogenic Substrate ◽  
Ph Optimum ◽  
Glucosidase Activity ◽  
Edematous Pancreatitis ◽  
Alpha Glucosidase

Abstract We measured the activity of a non-lysosomal alpha-glucosidase with pH optimum near 6.0 in serum from a wide variety of patients, using the fluorogenic substrate, 4-methylumbelliferyl-alpha-D-glucopyranoside. Acutely ill patients with cystic fibrosis (CF) demonstrated significant increases in alpha-glucosidase compared with CF outpatients. The former group of CF patients experienced far more severe chronic pulmonary disease than did the latter, whereas both groups had similar degrees of gastrointestinal impairment. Patients with pancreatitis associated with trauma or complicated by severe necrosis, hemorrhage, or abscess also displayed greater increases in alpha-glucosidase than did patients with uncomplicated (edematous) pancreatitis. For CF outpatients and patients with either edematous pancreatitis or pancreatic cancer, the alpha-glucosidase activity was similar to that for the general hospital-patient population. Corresponding changes were not observed for other measured serum glycosidases (alpha-fucosidase, alpha-mannosidase, beta-glucuronidase, beta-N-acetylglucosaminidase). Measurement of serum alpha-glucosidase may be of value in assessing the clinical course in CF and in differentiating necrotizing from edematous pancreatitis.

Non-operative Management of Necrotic Pancreatic Collection and Bleeding Pseudoaneurysm Communicating with Bowel Lumen at Multiple Sites: a Case Report and Review of the Literature

2016 ◽  
Vol 25 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Roshan Razik ◽  
Gary R. May ◽  
Fred Saibil
Keyword(s):  
Operative Management ◽  
Gastroduodenal Artery ◽  
Pancreatic Pseudocysts ◽  
Gallstone Pancreatitis ◽  
Endoscopic Retrograde ◽  
Pancreaticoduodenal Artery ◽  
Edematous Pancreatitis ◽  
Walled Off Necrosis ◽  
Non Operative Management ◽  
Guided Therapy

Pancreatic pseudocysts and foci of walled-off necrosis (WON) are well-known complications of acute pancreatitis. We present a case of severe gallstone pancreatitis complicated by WON, fistulization to the bowel and gastrointestinal bleeding. Bleeding was localized to a pseudoaneurysm of the gastroduodenal artery within the WON using imaging and endoscopy. Angiography and image-guided therapy were then used to control bleeding with coil-embolization. To our knowledge, this is the first report of non-operative management of a patient with severe pancreatitis complicated by WON and a bleeding pseudoaneurysm with multiple communications to the hollow viscera. Therapeutic options are discussed and a thorough literature review is included. Abbreviations: EGD: esophagogastroduodenoscopy; ERCP: endoscopic retrograde cholangiopancreatography; GDA: gastroduodenal artery; GI: gastrointestinal; IEP: interstitial edematous pancreatitis; IPDA: inferior pancreaticoduodenal artery; WON: walled-off necrosis.

Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis

1987 ◽  
Vol 253 (4) ◽  
pp. G508-G516 ◽  
Author(s):  
A. Saluja ◽  
S. Hashimoto ◽  
M. Saluja ◽  
R. E. Powers ◽  
J. Meldolesi ◽  
...  
Keyword(s):  
Cathepsin B ◽  
Cathepsin D ◽  
Lysosomal Enzymes ◽  
Digestive Enzyme ◽  
Saline Control ◽  
Zymogen Granules ◽  
Electron Microscopic ◽  
Edematous Pancreatitis ◽  
Supramaximal Stimulation ◽  
Digestive Enzyme Secretion

The subcellular distribution of the lysosomal enzymes cathepsin B and D in the pancreas was evaluated in rats infused with saline (control) or a maximal (0.25 microgram . kg-1 . h-1) or a supramaximally stimulating dose (5 micrograms . kg-1 . h-1) of the secretagogue caerulein. The latter results in acute edematous pancreatitis, inhibition of digestive enzyme secretion, and the localization of digestive zymogens in organelles whose fragility has been increased by caerulein infusion [A. Saluja et al. Am. J. Physiol. 249 (gastrointest. Liver Physiol. 12): G702-G710, 1985]. Samples from control animals were found to have 29.9 +/- 1.8% of the cathepsin B activity in the pellet centrifuged at 1,300 g for 15 min (containing primarily zymogen granules) and 54.7 +/- 2.5% in the pellet centrifuged at 12,000 g for 12 min (containing primarily lysosomes and mitochondria). After supramaximal stimulation with caerulein for 3.5 h the pellet centrifuged at 1,300 g for 15 min had 55.1 +/- 2.5%, and the pellet centrifuged at 12,000 g for 12 min had 30.6 +/- 2.0% of cathepsin B activity. This redistribution was time dependent, noted within 1 h of starting caerulein infusion, and maximal after 2.5 h of infusion. Electron microscopic immunolabeling studies revealed localization of cathepsin D in discrete organelles that, in the samples from animals infused with a supramaximally stimulating dose of caerulein, were larger, more abundant, and more concentrated in the pellet centrifuged at 1,300 g for 15 min than in the controls. During infusion with supramaximal doses of caerulein, the cathepsin B-containing organelles were found to become progressively more fragile.(ABSTRACT TRUNCATED AT 250 WORDS)

Sign in / Sign up

Export Citation Format

Share Document