Radiological Manifestations of Neonatal Renal Vein Thrombosis on Follow-Up Examinations

Radiology ◽  
1977 ◽  
Vol 122 (2) ◽  
pp. 435-438 ◽  
Author(s):  
Tudor J. Sutton ◽  
Antoine Leblanc ◽  
Noëlle Gauthier ◽  
Max Hassan
Keyword(s):  
Renal Vein ◽  
Renal Vein Thrombosis ◽  
Vein Thrombosis ◽  
Neonatal Renal Vein Thrombosis

An Attempt to Reach Consensus Regarding Management of Neonatal Renal Vein Thrombosis: The Canadian Pediatric Hemostasis and Thrombosis Network Experience.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4026-4026 ◽  
Author(s):  
L. R. Brandao ◽  
D. Dix ◽  
M. David ◽  
S. Israels ◽  
P. Massicotte ◽  
...  
Keyword(s):  
Renal Vein ◽  
Vena Cava ◽  
Renal Vein Thrombosis ◽  
Therapeutic Approaches ◽  
Vein Thrombosis ◽  
Neonatal Renal Vein Thrombosis ◽  
Frequent Site ◽  
Therapeutic Protocols ◽  
Work Up

Abstract Background: Renal vein thrombosis (RVT) is the most frequent site of primary venous thrombosis in neonates. At present, there is no conventional therapeutic regimen for this condition. Objective: To establish current clinical guidelines based on data from the Canadian Pediatric Hemostasis and Thrombosis Network (CPHTN). Materials and Methods: A standardized questionnaire was sent to CPHTN members involved with pediatric thrombosis care. Clinical variables included thrombus location (unilateral vs. bilateral), severity (non-occlusive vs. occlusive), extension to the inferior vena cava (IVC+), and concomitant bleeding at diagnosis [i.e. hematuria with thrombocytopenia (H/T+), with/without ≥ grade 2 intraventricular hemorrhage (IVH+/−)]. Results: A total of 16 pediatric hematologists participated, with a response rate of approximately 80%. Regarding diagnostic imaging, the most utilized methods were the following: a) Doppler ultrasound (U/S) in 14/16 (87.5%); b) U/S without Doppler in 1/16 (6.25%); and c) contrast venography in 1/16 (6.25%). 12/16 (75%) of the physicians would have ordered a thrombophilia work up. For unilateral, non-occlusive, H/T− or H/T+ cases, management included, respectively: 1) no therapy in 11/16 (68.75%) and 9/16 (56.25%); 2) low-molecular-weight heparin (LMWH) in 2/16 (12.5%) (3-month-course) and 3/16 (18.75%) (14-day or 3-month course); and 3) therapy based on radiologic follow up (f/u) in 3/16 (18.75%) and 4/16 (25%). For unilateral, occlusive, H/T+, IVH− or IVH+ cases, management included: 1) no therapy in 5/16 (31.25%) and 10/16 (62.5%); 2) LMWH in 6/16 (37.5%) and 4/16 (25%); and 3) treatment based on f/u findings in 5/16 (31.25%) and 2/16 (12.5%). For bilateral, occlusive, IVC−, IVH− cases, management included: 1) LMWH (2 weeks to 3 months) in 12/16 (75%); 2) tissue-plasminogen activator (t-PA) in 1/16 (6.25%); 3) LMWH and t-PA in 2/16 (12.5%); and 4) therapy based on f/u in 1/16 (6.25%). Finally, for bilateral, occlusive, IVC+, IVH− or +, the responses were, in that order: 1) LMWH (6 weeks to 3 months) in 10/16 (62.5%) and 11/16 (68.75%); 2) t-PA in 3/16 (18.75%) and 0/16; 3) LMWH and t-PA in 2/16 (12.5%) and 0/16; 4) treatment based on f/u in 1/16 (6.25%) in both groups; 5) no therapy in 2/16 (12.5%) of the latter group only; and 6) unknown in 2/16 (12.5%) of the latter group only. The anti-Xa level (0.5 to 1.0 range) was the only assay suggested for monitoring LMWH. Standard heparin was monitored by anti-Xa levels in only 3/16 (18.75%) of cases. Consultation sources included 1) combined sources (i.e. books, protocols, journals) in 10/16 (62.5%) cases; 2) journals in 4/16 (25%) cases; and 3) 1-800-NO-CLOTS in 2/16 (12.5%) cases. 15/16 (93.75%) of the participating physicians supported the idea of developing therapeutic protocols. Conclusions: Currently, there are no standard therapeutic practices with respect to neonatal RVT. It would be difficult to successfully complete a randomized clinical trial due to small numbers. However, multicenter, prospective studies utilizing consistent therapeutic approaches would be extremely helpful in this clinical setting.

Antenatal and neonatal renal vein thrombosis: New ultrasonic features with high frequency transducers

1996 ◽  
Vol 26 (9) ◽  
pp. 686-689 ◽  
Author(s):  
N. B. Wright ◽  
G. Blanch ◽  
S. Walkinshaw ◽  
D. W. Pilling
Keyword(s):  
High Frequency ◽  
Renal Vein ◽  
Renal Vein Thrombosis ◽  
Vein Thrombosis ◽  
Neonatal Renal Vein Thrombosis

Thrombectomy for Neonatal Renal Vein Thrombosis

1975 ◽  
Vol 113 (3) ◽  
pp. 396-399 ◽  
Author(s):  
Ian M. Thompson ◽  
Robert Schneider ◽  
Z. Lababidi
Keyword(s):  
Renal Vein ◽  
Renal Vein Thrombosis ◽  
Vein Thrombosis ◽  
Neonatal Renal Vein Thrombosis

A case series of 72 neonates with renal vein thrombosis

2004 ◽  
Vol 92 (10) ◽  
pp. 929-933 ◽  
Author(s):  
Stefan Kuhle ◽  
Patti Massicotte ◽  
Anthony Chan ◽  
Lesley Mitchell
Keyword(s):  
Renal Vein ◽  
Case Reports ◽  
Activated Protein C ◽  
Case Series ◽  
Renal Vein Thrombosis ◽  
Diagnostic Techniques ◽  
Small Subset ◽  
Vein Thrombosis ◽  
Neonatal Renal Vein Thrombosis ◽  
Associated Conditions

SummaryNeonatal renal vein thrombosis (RVT) is a well-recognized clinical entity which is associated with serious morbidity. However, current information regarding RVT has been restricted to case reports and small case series. In this study, it was our objective to describe patient demographics, clinical presentation, location and risk factors of RVT. For our study design, we looked at a case series of 72 neonates with RVT referred to the 1-800-NO-CLOTS consultation service between 9/1996 and 8/2001. Data on age, gender, associated conditions, prothrombotic disorders, family history, location of the thrombosis, diagnostic techniques, and treatment were prospectively recorded using a standardized form. Our results show that RVT affected males (65%, CI 52-76%) significantly more often than females (35%, CI 24-48%). Median age at presentation was 2 days (0-21 days). RVT was unilateral in 72% (left side: 67%, CI 49-81%; right side: 33%, CI 19-51%), and bilateral in 28%. The majority (83%) had at least one associated condition: Prematurity (54%), central venous lines (17%), a diabetic mother (13%), asphyxia (6%), infections (6%). Prothrombotic testing was performed in 21 neonates. Activated protein C resistance was found in 8 children (38%), other defects in three. This is the largest case series of neonatal RVT to date. Data from the study show that i) male infants are affected twice as often as females and ii) there appears to be a left-sided predominance of neonatal RVT. Neonatal RVT is only infrequently associated with the presence of a catheter as compared to thrombosis at other sites. The majority of infants have associated conditions with prematurity being most frequent. A small subset of neonates were screened for prothrombotic abnormalities and 50% of the children screened were positive.

Neonatal Renal Vein Thrombosis: Report of a Case

1998 ◽  
Vol 13 (1) ◽  
pp. 36
Author(s):  
J. C. Bohórquez-Sierra ◽  
M. J. Calvo-López ◽  
J. I. Martínez-León ◽  
M. Rodríguez-Piñero ◽  
F. Arribas-Aguilar ◽  
...  
Keyword(s):  
Renal Vein ◽  
Renal Vein Thrombosis ◽  
Vein Thrombosis ◽  
Neonatal Renal Vein Thrombosis

Neonatal Renal Vein Thrombosis: Review of the English-Language Literature Between 1992 and 2006

PEDIATRICS ◽  
2007 ◽  
Vol 120 (5) ◽  
pp. e1278-e1284 ◽  
Author(s):  
K. K. Lau ◽  
J. M. Stoffman ◽  
S. Williams ◽  
P. McCusker ◽  
L. Brandao ◽  
...  
Keyword(s):  
Renal Vein ◽  
English Language ◽  
Renal Vein Thrombosis ◽  
Vein Thrombosis ◽  
English Language Literature ◽  
Neonatal Renal Vein Thrombosis ◽  
Language Literature

Calcified neonatal renal vein thrombosis demonstration by CT and US

1990 ◽  
Vol 20 (3) ◽  
pp. 160-162 ◽  
Author(s):  
S. Jayogapal ◽  
H. L. Cohen ◽  
P. W. Brill ◽  
P. Winchester ◽  
D. Eaton
Keyword(s):  
Renal Vein ◽  
Renal Vein Thrombosis ◽  
Vein Thrombosis ◽  
Neonatal Renal Vein Thrombosis
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