Semiautomatic Optimization of External Beam Radiation Treatment Planning

Radiology ◽  
1974 ◽  
Vol 110 (1) ◽  
pp. 191-196 ◽  
Author(s):  
Louis Hodes
Keyword(s):  
Treatment Planning ◽  
Radiation Treatment ◽  
External Beam Radiation ◽  
External Beam ◽  
Radiation Treatment Planning ◽  
Beam Radiation

Consensus opinion on MRI simulation for external beam radiation treatment planning

2016 ◽  
Vol 121 (2) ◽  
pp. 187-192 ◽  
Author(s):  
Eric S. Paulson ◽  
Sjoerd P.M. Crijns ◽  
Brian M. Keller ◽  
Jihong Wang ◽  
Maria A. Schmidt ◽  
...  
Keyword(s):  
Treatment Planning ◽  
Radiation Treatment ◽  
External Beam Radiation ◽  
External Beam ◽  
Radiation Treatment Planning ◽  
Beam Radiation ◽  
Consensus Opinion

Age and Radiation Response in Glioblastoma Multiforme

Neurosurgery ◽  
2001 ◽  
Vol 49 (6) ◽  
pp. 1288-1298 ◽  
Author(s):  
Fred G. Barker ◽  
Susan M. Chang ◽  
David A. Larson ◽  
Penny K. Sneed ◽  
William M. Wara ◽  
...  
Keyword(s):  
Scale Score ◽  
Radiation Treatment ◽  
External Beam Radiation Therapy ◽  
Radiation Response ◽  
External Beam Radiation ◽  
Karnofsky Performance Scale ◽  
External Beam ◽  
Beam Radiation ◽  
Karnofsky Performance Scale Score ◽  
Performance Scale

ABSTRACT OBJECTIVE Advanced age is a strong predictor of shorter survival in patients with glioblastoma multiforme (GM), especially for those who receive multimodality treatment. Radiographically assessed tumor response to external beam radiation therapy is an important prognostic factor in GM. We hypothesized that older GM patients might have more radioresistant tumors. METHODS We studied radiographically assessed response to external beam radiation treatment (five-level scale) in relation to age and other prognostic factors in a cohort of 301 GM patients treated on two prospective clinical protocols. A total of 223 patients (74%) were assessable for radiographically assessed radiation response. A proportional odds ordinal regression model was used for univariate and multivariate analysis. RESULTS Younger age (P = 0.006), higher Karnofsky Performance Scale score before radiotherapy (P = 0.027), and more extensive surgical resection (P = 0.028) predicted better radiation response in univariate analyses. Results were similar when clinical criteria were used to classify an additional 61 patients without radiographically assessed radiation response (stable versus progressive disease). In multivariate analyses, age and extent of resection were significant independent predictors of radiation response (P < 0.05); Karnofsky Performance Scale score was of borderline significance (P = 0.07). CONCLUSION Older GM patients are less likely to have good responses to postoperative external beam radiation therapy. Karnofsky Performance Scale score before radiation treatment and extent of surgical resection are additional predictors of radiographically assessed radiation response in GM.

Sign in / Sign up

Export Citation Format

Share Document