Incrementalized pointer and escape analysis

Kotlin is a statically typed programming language that supports object-oriented and functional programming. It supports JVM, JS and native platforms via LLVM (Kotlin / Native). The first two targets are backed with well-developed virtual machines that can perform advanced program optimizations at runtime. However, for native platforms, all optimizations must be performed at compile time. Currently Kotlin / Native lacks many optimizations, which is why the performance of the generated code is poor in many cases. This paper describes a way to solve this problem by introducing an additional SSA-based intermediate representation and implementing escape analysis using it. Experimental results have shown that this approach can significantly improve performance.

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Putting escape analysis to work for software testing

International Conference on Software Maintenance 2002 Proceedings ICSM-02 ◽

10.1109/icsm.2002.1167800 ◽

2003 ◽

Cited By ~ 1

Author(s):

A.L. Souter ◽

L.L. Pollock

Keyword(s):

Software Testing ◽

Escape Analysis

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TRAIL signalling promotes entosis in colorectal cancer

10.1101/2020.09.29.315317 ◽

2020 ◽

Author(s):

Emir Bozkurt ◽

Heiko Düssmann ◽

Manuela Salvucci ◽

Brenton L. Cavanagh ◽

Sandra Van Schaeybroeck ◽

...

Keyword(s):

Colorectal Cancer ◽

Cell Death ◽

Death Receptor ◽

Knock Out ◽

Caspase Inhibition ◽

Escape Analysis ◽

Show Evidence ◽

Death Receptor Ligand ◽

Microscopy Analysis ◽

Patient Prognosis

AbstractEntosis is a form of non-phagocytic cell-in-cell (CIC) interaction where a living cell enters into another. Tumours show evidence of entosis, however factors controlling entosis remain to be elucidated. Here we find that the death receptor ligand TRAIL is a potent activator of entosis in colon cancer cells. CLEM/3D confocal microscopy analysis revealed ultrastructural features of entosis and subsequent entotic cell death of inner cells upon TRAIL treatment. Induction of entosis and apoptosis by TRAIL were mutually exclusive events but both required the presence of caspase-8. Bax/Bak double knock-out or caspase inhibition altered the fate of inner cells from entotic cell death to survival and escape. Analysis of colorectal cancer tumours showed a significant association between expression levels of TRAIL and CICs. Notably, the presence of CICs in the invasive front regions of colorectal tumours was significantly correlated with adverse patient prognosis.

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