Data-driven Optimisation of in vivo Radioactive Source-tracking for Real-time Cancer Radiotherapy Treatment Verification

2020 ◽  
Author(s):  
Negin Foroughimehr ◽  
Ali Yavari ◽  
Max Hanlon ◽  
Jordan Wallace ◽  
Ryan Smith ◽  
...  
Keyword(s):  
Real Time ◽  
Radioactive Source ◽  
Data Driven ◽  
Source Tracking ◽  
Cancer Radiotherapy ◽  
Treatment Verification ◽  
Radiotherapy Treatment

scholarly journals A Monte Carlo study on the feasibility of real-time in vivo source tracking during ultrasound based HDR prostate brachytherapy treatments

2019 ◽  
Vol 59 ◽  
pp. 30-36 ◽  
Author(s):  
Joel Poder ◽  
Dean Cutajar ◽  
Susanna Guatelli ◽  
Marco Petasecca ◽  
Andrew Howie ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Real Time ◽  
Monte Carlo Study ◽  
Source Tracking ◽  
Prostate Brachytherapy

TU-F-BRE-01: A High Resolution Micro Fiber Scintillator Detector Optimized for SRS and SBRT in Vivo Real Time Treatment Verification

2014 ◽  
Vol 41 (6Part27) ◽  
pp. 468-468
Author(s):  
E Izaguirre ◽  
S Price ◽  
T Knewtson ◽  
S Loyalka ◽  
D Rangaraj
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Treatment Verification ◽  
Time Treatment ◽  
Scintillator Detector

scholarly journals Camera selection for real-time in vivo radiation treatment verification systems using Cherenkov imaging

2015 ◽  
Vol 42 (2) ◽  
pp. 994-1004 ◽  
Author(s):  
Jacqueline M. Andreozzi ◽  
Rongxiao Zhang ◽  
Adam K. Glaser ◽  
Lesley A. Jarvis ◽  
Brian W. Pogue ◽  
...  
Keyword(s):  
Real Time ◽  
Radiation Treatment ◽  
Treatment Verification ◽  
Camera Selection ◽  
Selection For ◽  
Verification Systems ◽  
Cherenkov Imaging

MO-AB-BRA-03: Development of Novel Real Time in Vivo EPID Treatment Verification for Brachytherapy

2016 ◽  
Vol 43 (6Part28) ◽  
pp. 3691-3691 ◽  
Author(s):  
G Fonseca ◽  
M Podesta ◽  
B Reniers ◽  
F Verhaegen
Keyword(s):  
Real Time ◽  
Treatment Verification

A High-Performance Dosimetry System for In Vivo HDR Brachytherapy: Real Time Source Tracking and Dose Measurements

Brachytherapy ◽  
2019 ◽  
Vol 18 (3) ◽  
pp. S19-S20
Author(s):  
Haydee Maria Linares Rosales ◽  
Louis Archambault ◽  
Sam Beddar ◽  
Luc Beaulieu
Keyword(s):  
Real Time ◽  
High Performance ◽  
Source Tracking ◽  
Hdr Brachytherapy ◽  
Dosimetry System ◽  
Dose Measurements

scholarly journals EP-1502: High resolution portal image prediction for radiotherapy treatment verification & in vivo dosimetry

2014 ◽  
Vol 111 ◽  
pp. S162
Author(s):  
D. Patin ◽  
E. Barat ◽  
T. Dautremer ◽  
T. Montagu ◽  
C. Le Loirec ◽  
...  
Keyword(s):  
High Resolution ◽  
In Vivo Dosimetry ◽  
Treatment Verification ◽  
Image Prediction ◽  
Radiotherapy Treatment

Voltammetric Detection of Tetrodotoxin Real-Time In Vivo of Mouse Organs using DNA-Immobilized Carbon Nanotube Sensors

2019 ◽  
Vol 15 (5) ◽  
pp. 567-574
Author(s):  
Huck Jun Hong ◽  
Suw Young Ly
Keyword(s):  
Carbon Nanotube ◽  
Real Time ◽  
Anticancer Agents ◽  
Cancer Metastasis ◽  
Anodic Stripping Voltammetry ◽  
Stripping Voltammetry ◽  
Takifugu Rubripes ◽  
In Vivo Detection ◽  
Voltammetric Detection

Background: Tetrodotoxin (TTX) is a biosynthesized neurotoxin that exhibits powerful anticancer and analgesic abilities by inhibiting voltage-gated sodium channels that are crucial for cancer metastasis and pain delivery. However, for the toxin’s future medical applications to come true, accurate, inexpensive, and real-time in vivo detection of TTX remains as a fundamental step. Methods: In this study, highly purified TTX extracted from organs of Takifugu rubripes was injected and detected in vivo of mouse organs (liver, heart, and intestines) using Cyclic Voltammetry (CV) and Square Wave Anodic Stripping Voltammetry (SWASV) for the first time. In vivo detection of TTX was performed with auxiliary, reference, and working herring sperm DNA-immobilized carbon nanotube sensor systems. Results: DNA-immobilization and optimization of amplitude (V), stripping time (sec), increment (mV), and frequency (Hz) parameters for utilized sensors amplified detected peak currents, while highly sensitive in vivo detection limits, 3.43 µg L-1 for CV and 1.21 µg L-1 for SWASV, were attained. Developed sensors herein were confirmed to be more sensitive and selective than conventional graphite rodelectrodes modified likewise. A linear relationship was observed between injected TTX concentration and anodic spike peak height. Microscopic examination displayed coagulation and abnormalities in mouse organs, confirming the powerful neurotoxicity of extracted TTX. Conclusion: These results established the diagnostic measures for TTX detection regarding in vivo application of neurotoxin-deviated anticancer agents and analgesics, as well as TTX from food poisoning and environmental contamination.

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