Participant Selection Problem

Author(s):  
C. Y. Lin ◽  
J. W. S. Liu ◽  
K. L. Yeh ◽  
E. T. H. Chu
2004 ◽  
Vol 09 (01) ◽  
Author(s):  
Teresa León ◽  
Vicente Liern ◽  
Paulina Marco ◽  
Enriqueta Vercher ◽  
José Vicente Segura

Author(s):  
Jamie E. Mondello ◽  
Jenny E. Pak ◽  
Dennis F. Lovelock ◽  
Terrence Deak

Most mental health problems associated with psychological distress originate with activation of centrally regulated stress pathways, yet a diverse range of central nervous system and somatic disease states can be influenced by exposure to severe or unrelenting stress. The goal of this chapter is to provide a conceptual framework to guide the development of pharmacological intervention strategies. We propose that careful consideration of the relationship between the timing of stressful life experiences, pharmacological intervention, and the ultimate expression of disease symptomatology is critical for the development of pharmacological interventions to treat stress-related disorders. We review a range of physiological systems that are known to be activated by stress, offering potentially new targets for drug development efforts, and argue that participant selection is a key predictor of drug efficacy trials. In doing so, we point toward inflammatory signaling pathways as a potential final common mediator of multiple stress-related disease states.


2021 ◽  
pp. 1-18
Author(s):  
Mahima Poonia ◽  
Rakesh Kumar Bajaj

In the present work, the adjacency matrix, the energy and the Laplacian energy for a picture fuzzy graph/directed graph have been introduced along with their lower and the upper bounds. Further, in the selection problem of decision making, a methodology for the ranking of the available alternatives has been presented by utilizing the picture fuzzy graph and its energy/Laplacian energy. For the shake of demonstrating the implementation of the introduced methodology, the task of site selection for the hydropower plant has been carried out as an application. The originality of the introduced approach, comparative remarks, advantageous features and limitations have also been studied in contrast with intuitionistic fuzzy and Pythagorean fuzzy information.


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