scholarly journals FORMATION AND LIFE-TIME OF MEMORY DOMAINS IN THE DISSIPATIVE QUANTUM MODEL OF BRAIN

2000 ◽  
Vol 14 (08) ◽  
pp. 853-868 ◽  
Author(s):  
ELEONORA ALFINITO ◽  
GIUSEPPE VITIELLO
Keyword(s):  
Time Dependence ◽  
Life Time ◽  
External World ◽  
Neural Circuitry ◽  
Quantum Model ◽  
Electrical Dipole ◽  
Internal Parameters ◽  
Memory States ◽  
The Brain ◽  
Dynamic Formation

We show that in the dissipative quantum model of brain the time-dependence of the frequencies of the electrical dipole wave quanta leads to the dynamical organization of the memories in space (i.e., to their localization in more or less diffused regions of the brain) and in time (i.e., to their longer or shorter life-time). The life-time and the localization in domains of the memory states also depend on internal parameters and on the number of links that the brain establishes with the external world. These results agree with the physiological observations of the dynamic formation of neural circuitry which grows as brain develops and relates to external world.

scholarly journals DISSIPATION AND MEMORY CAPACITY IN THE QUANTUM BRAIN MODEL

1995 ◽  
Vol 09 (08) ◽  
pp. 973-989 ◽  
Author(s):  
GIUSEPPE VITIELLO
Keyword(s):  
Time Reversal ◽  
Coherent States ◽  
Memory Capacity ◽  
Quantum Model ◽  
Time Reversal Symmetry ◽  
Information Recording ◽  
New Information ◽  
Memory States ◽  
Sequential Information ◽  
The Brain

The quantum model of the brain proposed by Ricciardi and Umezawa is extended to dissipative dynamics in order to study the problem of memory capacity. It is shown that infinitely many vacua are accessible to memory printing in a way that in sequential information recording the storage of a new information does not destroy the previously stored ones, thus allowing a huge memory capacity. The mechanism of information printing is shown to induce breakdown of time-reversal symmetry. Thermal properties of the memory states, as well as their relation with squeezed coherent states, are finally discussed.

Abstract MP16: Excessive White Matter Hyperintensity Burden and Functional Outcomes After Acute Ischemic Stroke

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Sungmin Hong ◽  
Anne-katrin Giese ◽  
Markus D Schirmer ◽  
Adrian V Dalca ◽  
Anna Bonkhoff ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
White Matter ◽  
Acute Ischemic Stroke ◽  
Functional Outcomes ◽  
Life Time ◽  
Stroke Recovery ◽  
White Matter Hyperintensity ◽  
Brain Health ◽  
Stroke Outcomes ◽  
The Brain

Objective: Ability of the brain to recover after an acute ischemic stroke (AIS) is linked to the pre-stroke burden of white matter hyperintensity (WMH), a radiographic marker of brain health. We sought to determine the excessive WMH burden in an AIS population and investigate its association with 3-month stroke outcomes. Data: We used 2,435 subjects from the MRI-GENIE study. Three-month functional outcomes of 872 subjects among those subjects were measured by 90-day modified Ranking Scale (mRS). Methods: We automatically quantified WMH volume (WMHv) on FLAIR images and adjusted for a brain volume. We modeled a trend using the factor analysis (FA) log-linear regression using age, sex, atrial fibrillation, diabetes, hypertension, coronary artery disease and smoking as input variables. We categorized three WMH burden groups based on the conditional probability given by the model (LOW: lower 33%, MED: middle 34%, and HIGH: upper 33%). The subgroups were compared with respect to mRS (median and dichotomized odds ratio (OR) (good/poor: mRS 0-2/3-6)). Results: Five FA components out of seven with significant relationship to WMHv (p<0.001) were used for the regression modeling (R 2 =0.359). The HIGH group showed higher median (median=2, IQR=2) mRS score than LOW (median=1, IQR=1) and MED (median=1, IQR=1). The odds (OR) of good AIS outcome for LOW and MED were 1.8 (p=0.0001) and 1.6 (p=0.006) times higher than HIGH, respectively. Conclusion: Once accounted for clinical covariates, the excessive WMHv was associated with worse 3-month stroke outcomes. These data suggest that a life-time of injury to the white matter reflected in WMH is an important factor for stroke recovery and an indicator of the brain health.

Evaluation of the activity of antihypoxants with an isothiourea structure in a model of hypercapnic hypoxia with a shutdown of the cerebral hemispheres

2021 ◽  
Vol 19 (1) ◽  
pp. 55-63
Author(s):  
Vera V. Marysheva ◽  
Vladimir V. Mikheev ◽  
Petr D. Shabanov
Keyword(s):  
Acute Hypoxia ◽  
Life Time ◽  
The Body ◽  
Cerebral Hemispheres ◽  
Antihypoxic Activity ◽  
Hypoxic Episode ◽  
Hypoxia With Hypercapnia ◽  
Hypercapnic Hypoxia ◽  
Outbred Mice ◽  
The Brain

PURPOSE: To study the effect of amtizol, 2-aminobenzthiazole (2-ABT) and 2-amino-4-acetylthiazolo[5,4-b]indole (BM-606) on the resistance of male outbred mice to acute hypoxia with hypercapnia under conditions of isolated functioning of one from the hemispheres, as well as both hemispheres of the brain. METHODS: A model of acute hypoxia with hypercapnia (canned hypoxia) was used in mice of the same mass, the lifespan of all animals was determined. Temporary shutdown of the cortex of one of the hemispheres or both hemispheres was achieved by epidural application of filter paper moistened with 25% potassium chloride solution, creating a spreading depression according to Leao. Amtizol, 2-aminobenzthiazole (2-ABT) and 2-amino-4-acetylthiazolo[5,4-b]indole (BM-606) at equimolar doses of 25, 32.5, and 50 mg/kg, respectively were used as pharmacological analyzers, the compounds were injected intraperitoneally 30 min before the hypoxic episode. RESULTS: It was shown that, in contrast to amtizol, 2-ABT and VM-606 increase the life time of experimental animals when any hemisphere is turned off. The use of drugs when both hemispheres were turned off revealed that amtizol has approximately equal effect on the brain and the rest of the body, in 2-ABT antihypoxic activity is 1/3 associated with the brain, in VM-606 exclusively with the brain. CONCLUSION: The experimental model used in this work makes it possible to quite easily evaluate the effect of either one drug or compare several drugs, their role in the functioning of the cerebral hemispheres, on which part of the sample highly resistant or low resistant to hypoxia they have the greatest effect.

scholarly journals Time dependence and distribution of hematoporphyrin derivative in the brain tumor

1985 ◽  
Vol 5 (3) ◽  
pp. 73-78
Author(s):  
Sadao Kaneko ◽  
Kouichi Tokuda ◽  
Shinji Sugimoto ◽  
Hiroshi Abe ◽  
Yoshihiro Kakiuchi ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Time Dependence ◽  
Hematoporphyrin Derivative ◽  
The Brain

scholarly journals Archetype, Psyche, World

2022 ◽  
pp. 1-20
Author(s):  
Jon Mills
Keyword(s):  
Theory Of Mind ◽  
Body Problem ◽  
External World ◽  
Analytical Psychology ◽  
Metaphysical Realism ◽  
Internal Parameters ◽  
New Directions ◽  
Mind Body Problem ◽  
The Mind ◽  
Ontological Position

Abstract In our dialogues over the nature of archetypes, essence, psyche, and world, I further respond to Erik Goodwyn’s recent foray into establishing an ontological position that not only answers to the mind-body problem, but further locates the source of Psyche on a cosmic plane. His impressive attempt to launch a neo-Jungian metaphysics is based on the principle of cosmic panpsychism that bridges both the internal parameters of archetypal process and their emergence in consciousness and the external world conditioned by a psychic universe. Here I explore the ontology of experience, mind, matter, metaphysical realism, and critique Goodwyn’s turn to Neoplatonism. The result is a potentially compatible theory of mind and reality that grounds archetypal theory in onto-phenomenology, metaphysics, and bioscience, hence facilitating new directions in analytical psychology.

scholarly journals Neural Circuitry of Information Seeking

2020 ◽  
Author(s):  
Ethan Bromberg-Martin ◽  
Ilya E. Monosov
Keyword(s):  
Basal Ganglia ◽  
Information Seeking ◽  
Neural Circuitry ◽  
Uncertain Environments ◽  
Information Preferences ◽  
Motivated Behavior ◽  
Uncertain Future ◽  
The Brain ◽  
Primary Reward ◽  
Do So

Humans and animals navigate uncertain environments by seeking information about the future. Remarkably, we often seek information even when it has no instrumental value for aiding our decisions – as if the information is a source of value in its own right. In recent years, there has been a flourishing of research into these non-instrumental information preferences and their implementation in the brain. Individuals value information about uncertain future rewards, and do so for multiple reasons, including valuing resolution of uncertainty and overweighting desirable information. The brain motivates this information seeking by tapping into some of the same circuitry as primary rewards like food and water. However, it also employs cortex and basal ganglia circuitry that predicts and values information as distinct from primary reward. Uncovering how these circuits cooperate will be fundamental to understanding information seeking and motivated behavior as a whole, in our increasingly complex and information-rich world.

scholarly journals A method for single-neuron chronic recording from the retina in awake mice

Science ◽  
2018 ◽  
Vol 360 (6396) ◽  
pp. 1447-1451 ◽  
Author(s):  
Guosong Hong ◽  
Tian-Ming Fu ◽  
Mu Qiao ◽  
Robert D. Viveros ◽  
Xiao Yang ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Visual Information ◽  
Single Neuron ◽  
Ganglion Cells ◽  
Ex Vivo ◽  
Neural Circuitry ◽  
Retinal Ganglion ◽  
Chronic Recording ◽  
The Brain

The retina, which processes visual information and sends it to the brain, is an excellent model for studying neural circuitry. It has been probed extensively ex vivo but has been refractory to chronic in vivo electrophysiology. We report a nonsurgical method to achieve chronically stable in vivo recordings from single retinal ganglion cells (RGCs) in awake mice. We developed a noncoaxial intravitreal injection scheme in which injected mesh electronics unrolls inside the eye and conformally coats the highly curved retina without compromising normal eye functions. The method allows 16-channel recordings from multiple types of RGCs with stable responses to visual stimuli for at least 2 weeks, and reveals circadian rhythms in RGC responses over multiple day/night cycles.

Ex Vivo Brain Preparation to Analyze Vocal Pathways of Xenopus Frogs

2021 ◽  
Vol 2021 (9) ◽  
pp. pdb.prot106872
Author(s):  
Ayako Yamaguchi
Keyword(s):  
Neural Activity ◽  
Ex Vivo ◽  
Neural Circuitry ◽  
Neural Basis ◽  
Vocal Production ◽  
Basic Principles ◽  
Electrophysiological Recordings ◽  
The Brain

Understanding the neural basis of behavior is a challenging task for technical reasons. Most methods of recording neural activity require animals to be immobilized, but neural activity associated with most behavior cannot be recorded from an anesthetized, immobilized animal. Using amphibians, however, there has been some success in developing in vitro brain preparations that can be used for electrophysiological and anatomical studies. Here, we describe an ex vivo frog brain preparation from which fictive vocalizations (the neural activity that would have produced vocalizations had the brain been attached to the muscle) can be elicited repeatedly. When serotonin is applied to the isolated brains of male and female African clawed frogs, Xenopus laevis, laryngeal nerve activity that is a facsimile of those that underlie sex-specific vocalizations in vivo can be readily recorded. Recently, this preparation was successfully used in other species within the genus including Xenopus tropicalis and Xenopus victorianus. This preparation allows a variety of techniques to be applied including extracellular and intracellular electrophysiological recordings and calcium imaging during vocal production, surgical and pharmacological manipulation of neurons to evaluate their impact on motor output, and tract tracing of the neural circuitry. Thus, the preparation is a powerful tool with which to understand the basic principles that govern the production of coherent and robust motor programs in vertebrates.

Herbert Mac Cabe’s Philosophical Anthropology

Politeia ◽  
2019 ◽  
Vol 1 (4) ◽  
pp. 238-260
Author(s):  
Franco Manni ◽  
Keyword(s):  
Philosophical Anthropology ◽  
External World ◽  
The Other ◽  
Human Being ◽  
Language System ◽  
Other Hand ◽  
The One ◽  
The Individual ◽  
The Brain ◽  
Individual Human

From the ideas of Aristotle, De Saussure and Wittgenstein, philosopher Herbert McCabe elaborated an original anthropology. 'Meaning' means: the role played by a part towards the whole. Senses are bodily organs and sensations allow an animal to get fragments of the external world which become 'meaningful' for the behaviour of the whole animal Besides sensations, humans are ‘linguistic animals’ because through words they are able to 'communicate', that is, to share a peculiar kind of meanings: concepts. Whereas, sense-images are stored physically in our brain and cannot be shared, even though we can relate to sense-images by words (speech coincides with thought). However, concepts do not belong to the individual human being qua individual, but to an interpersonal entity: the language system. Therefore, on the one hand, to store images is a sense-power and an operation of the brain, whereas the brain (quite paradoxically!) is not in itself the organ of thought. On the other hand, concepts do not exist on their own.

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