A World Federation of Institutes of Advanced Study

1989 ◽  
pp. 235-241
Keyword(s):  
World Federation ◽  
Advanced Study

The Mental Health and Social Exclusion European Network

2000 ◽  
Vol 5 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Luigi Leonori ◽  
Manuel Muñoz ◽  
Carmelo Vázquez ◽  
José J. Vázquez ◽  
Mary Fe Bravo ◽  
...  
Keyword(s):  
Mental Health ◽  
European Union ◽  
Social Exclusion ◽  
Mentally Ill ◽  
Outcome Evaluation ◽  
World Federation ◽  
The European Union ◽  
Capital Cities ◽  
Homeless Mentally Ill ◽  
The Impact

This report concerns the activities developed by the Mental Health and Social Exclusion (MHSE) Network, an initiative supported by the Mental Health Europe (World Federation of Mental Health). We report some data from the preliminary survey done in five capital cities of the European Union (Madrid, Copenhagen, Brussels, Lisbon, and Rome). The main aim of this survey was to investigate, from a mostly qualitative point of view, the causal and supportive factors implicated in the situation of the homeless mentally ill in Europe. The results point out the familial and childhood roots of homelessness, the perceived causes of the situation, the relationships with the support services, and the expectations of future of the homeless mentally ill. The analysis of results has helped to identify the different variables implicated in the social rupture process that influences homelessness in major European cities. The results were used as the basis for the design of a more ambitious current research project about the impact of the medical and psychosocial interventions in the homeless. This project is being developed in 10 capital cities of the European Union with a focus on the program and outcome evaluation of the health and psychosocial services for the disadvantaged.

MENGGAGAS PETA JALAN (ROAD MAP) KERJASAMA GEREJA-GEREJA DI SUMATERA UTARA: MENELISIK ULANG SIGNIFIKANSI PGI-W, UEM DAN KN-LWF

2020 ◽  
Author(s):  
Ramli Harahap
Keyword(s):  
World Federation ◽  
Road Map

Kata menggagas berarti memikirkan sesuatu. Kata ini cocok untuk sebuah usaha perintisan yang mau memulai sebuah rencana dan jalan. Artinya, sesuatu itu belum ada dan masih harus dipikirkan dan diusahakan untuk diwujudnyatakan. Kata menggagas peta jalan kerjasama Gereja-gereja di Sumatera Utara sebenarnya tidak cocok lagi, karena pada dasarnya kerjasama di antara semua Gereja-gereja yang ada di Sumatera Utara sudah mulai dikerjakan oleh Gereja-gereja yang ada di Sumatera Utara. Kerjasama Gereja-gereja di Sumatera Utara ini sudah terwujud dalam berbagai organiasi, seperti: Persekutuan Gereja-gereja Indonesia Wilayah Sumatera Utara (PGIW-SU), Sekretaris Bersama United Evangelical Mission (Sekber UEM), Komite Nasional Lutheran World Federation (KN-LWF), Badan Kerjasama Antar Gereja-gereja (BKAG), Badan Musyawarah Agama-gama (BAMAG), Lembaga Komunikasi Sejahtera (LKS), dan lain-lain.

Nimodipine pharmacokinetics after intraventricular injection of sustained-release nimodipine for subarachnoid hemorrhage

2021 ◽  
Vol 134 (1) ◽  
pp. 95-101 ◽  
Author(s):  
R. Loch Macdonald ◽  
Daniel Hänggi ◽  
Poul Strange ◽  
Hans Jakob Steiger ◽  
J Mocco ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Sustained Release ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
External Ventricular Drain ◽  
Plasma Concentrations ◽  
Intraventricular Injection ◽  
World Federation ◽  
Maximum Plasma ◽  
Clinical Trial Registration ◽  
Sustained Release Formulation

OBJECTIVEThe objective of this study was to measure the concentration of nimodipine in CSF and plasma after intraventricular injection of a sustained-release formulation of nimodipine (EG-1962) in patients with aneurysmal subarachnoid hemorrhage (SAH).METHODSPatients with SAH repaired by clip placement or coil embolization were randomized to EG-1962 or oral nimodipine. Patients were classified as grade 2–4 on the World Federation of Neurosurgical Societies grading scale for SAH and had an external ventricular drain inserted as part of their standard of care. Cohorts of 12 patients received 100–1200 mg of EG-1962 as a single intraventricular injection (9 per cohort) or they remained on oral nimodipine (3 per cohort). Plasma and CSF were collected from each patient for measurement of nimodipine concentrations and calculation of maximum plasma and CSF concentration, area under the concentration-time curve from day 0 to 14, and steady-state concentration.RESULTSFifty-four patients in North America were randomized to EG-1962 and 18 to oral nimodipine. Plasma concentrations increased with escalating doses of EG-1962, remained stable for 14 to 21 days, and were detectable at day 30. Plasma concentrations in the oral nimodipine group were more variable than for EG-1962 and were approximately equal to those occurring at the EG-1962 800-mg dose. CSF concentrations of nimodipine in the EG-1962 groups were 2–3 orders of magnitude higher than in the oral nimodipine group, in which nimodipine was only detected at low concentrations in 10% (21/213) of samples. In the EG-1962 groups, CSF nimodipine concentrations were 1000 times higher than plasma concentrations.CONCLUSIONSPlasma concentrations of nimodipine similar to those achieved with oral nimodipine and lasting for 21 days could be achieved after a single intraventricular injection of EG-1962. The CSF concentrations from EG-1962, however, were at least 2 orders of magnitude higher than those with oral nimodipine. These results supported a phase 3 study that demonstrated a favorable safety profile for EG-1962 but yielded inconclusive efficacy results due to notable differences in clinical outcome based on baseline disease severity.Clinical trial registration no.: NCT01893190 (ClinicalTrials.gov).

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