Artificial Radioactive Tracers: Applications to Chemistry and Medicine

1994 ◽  
pp. 211-216
Author(s):  
Glenn T. Seaborg
Keyword(s):  
Radioactive Tracers

scholarly journals Preclinical Testing of Radiopharmaceuticals for the Detection and Characterization of Osteomyelitis: Experiences from a Porcine Model

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4221
Author(s):  
Aage Kristian Olsen Alstrup ◽  
Svend Borup Jensen ◽  
Ole Lerberg Nielsen ◽  
Lars Jødal ◽  
Pia Afzelius
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Porcine Model ◽  
Animal Experiments ◽  
Radioactive Tracers ◽  
The Individual ◽  
Selection Of

The development of new and better radioactive tracers capable of detecting and characterizing osteomyelitis is an ongoing process, mainly because available tracers lack selectivity towards osteomyelitis. An integrated part of developing new tracers is the performance of in vivo tests using appropriate animal models. The available animal models for osteomyelitis are also far from ideal. Therefore, developing improved animal osteomyelitis models is as important as developing new radioactive tracers. We recently published a review on radioactive tracers. In this review, we only present and discuss osteomyelitis models. Three ethical aspects (3R) are essential when exposing experimental animals to infections. Thus, we should perform experiments in vitro rather than in vivo (Replacement), use as few animals as possible (Reduction), and impose as little pain on the animal as possible (Refinement). The gain for humans should by far exceed the disadvantages for the individual experimental animal. To this end, the translational value of animal experiments is crucial. We therefore need a robust and well-characterized animal model to evaluate new osteomyelitis tracers to be sure that unpredicted variation in the animal model does not lead to a misinterpretation of the tracer behavior. In this review, we focus on how the development of radioactive tracers relies heavily on the selection of a reliable animal model, and we base the discussions on our own experience with a porcine model.

scholarly journals Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo

ACS Nano ◽  
2021 ◽  
Vol 15 (2) ◽  
pp. 3212-3227
Author(s):  
Elisa Lázaro-Ibáñez ◽  
Farid N. Faruqu ◽  
Amer F. Saleh ◽  
Andreia M. Silva ◽  
Julie Tzu-Wen Wang ◽  
...  
Keyword(s):  
Extracellular Vesicle ◽  
Radioactive Tracers ◽  
Selection Of

Determination of the ambipolar field in medium pressure neondischarges using radioactive tracers

1975 ◽  
Vol 15 (5) ◽  
pp. 235-250
Author(s):  
L. C. J. Baghuis ◽  
M. Prins ◽  
H. L. Hagedoorn ◽  
J. A. V. D. Heide
Keyword(s):  
Radioactive Tracers ◽  
Medium Pressure

HYDROGEN PEROXIDE AND ITS ANALOGUES: II. PHASE EQUILIBRIUM IN THE SYSTEM HYDROGEN PEROXIDE – WATER

1951 ◽  
Vol 29 (2) ◽  
pp. 123-132 ◽  
Author(s):  
William T. Foley ◽  
Paul A. Giguère
Keyword(s):  
Hydrogen Peroxide ◽  
Phase Equilibrium ◽  
Solid Solutions ◽  
Freezing Point ◽  
Platinum Resistance Thermometer ◽  
Platinum Resistance ◽  
Radioactive Tracers ◽  
Resistance Thermometer ◽  
Pure Solution

A precision freezing point apparatus with platinum resistance thermometer was used to investigate the system hydrogen peroxide – water over the whole concentration range. The freezing point of the purest sample of hydrogen peroxide obtained by repeated fractional crystallizations of a large quantity of 99.6% pure solution was found to be −0.461°C; that of the dihydrate was −52.10°C. The two eutectics occur at concentrations of 45.2% and 61.2% H2O2 and at temperatures of −52.4° and −56.5°C. respectively. Contrary to what has been reported previously, water and hydrogen peroxide do not form solid solutions together. This was proved conclusively by applying the technique of radioactive tracers to the 'wet residue' method of Schreinemakers.

The labelling of mammalian spermatozoa with radioactive tracers

1958 ◽  
Vol 137 (3) ◽  
pp. 363-388 ◽  
Author(s):  
J. L. Sirlin ◽  
R. G. Edwards
Keyword(s):  
Radioactive Tracers ◽  
Mammalian Spermatozoa

Characterization of a packed column using radioactive tracers

1999 ◽  
Vol 54 (1) ◽  
pp. 91-101 ◽  
Author(s):  
V. Blet ◽  
Ph. Berne ◽  
C. Chaussy ◽  
S. Perrin ◽  
D. Schweich
Keyword(s):  
Packed Column ◽  
Radioactive Tracers

Vacuum Manifold for Rapid Assay of Enzymes Using Radioactive Tracers and Ion Exchange Chromatography

1971 ◽  
Vol 42 (4) ◽  
pp. 493-494
Author(s):  
Stanley B. Prusiner ◽  
Larry S. Milner ◽  
Carl W. Long ◽  
Murrel L. Myers
Keyword(s):  
Ion Exchange ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Radioactive Tracers ◽  
Rapid Assay
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