Somatostatin reduces plasma growth hormone levels during seawater adaptation in coho salmon, Oncorhynchus kisutch

1986 ◽  
Vol 64 (9) ◽  
pp. 2062-2063 ◽  
Author(s):  
R. M. Sweeting ◽  
B. A. McKeown
Keyword(s):  
Growth Hormone ◽  
Inhibitory Action ◽  
Coho Salmon ◽  
Oncorhynchus Kisutch ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Plasma Growth Hormone ◽  
Seawater Adaptation ◽  
Hormone Levels ◽  
Potent Growth

Plasma growth hormone levels were measured in coho salmon exposed to seawater to examine whether somatostatin has growth hormone release inhibitory action in salmon. Somatostatin (2 μg/10 g body weight) was injected prior to exposure to seawater and samples were taken 6 and 12 h postexposure. The results indicate that somatostatin does have potent growth hormone release inhibitory action in salmon, as it does in other teleosts.

Plasma growth hormone levels in normal and stunted yearling coho salmon,Oncorhynchus kisutch

1987 ◽  
Vol 242 (3) ◽  
pp. 379-382 ◽  
Author(s):  
Jonathan P. Bolton ◽  
Graham Young ◽  
Richard S. Nishioka ◽  
Tetsuya Hirano ◽  
Howard A. Bern
Keyword(s):  
Growth Hormone ◽  
Coho Salmon ◽  
Oncorhynchus Kisutch ◽  
Plasma Growth Hormone ◽  
Hormone Levels

THE STIMULATION OF GROWTH HORMONE RELEASE BY ACTH AND ITS INHIBITION BY SOMATOSTATIN

1976 ◽  
Vol 81 (2) ◽  
pp. 263-269 ◽  
Author(s):  
J. Köbberling ◽  
H. Jüppner ◽  
R. D. Hesch
Keyword(s):  
Growth Hormone ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Control Test ◽  
Plasma Growth Hormone ◽  
Normal Volunteers ◽  
Rapid Injection ◽  
Distinct Increase ◽  
Stimulation Of

ABSTRACT The rapid injection of 0.5 or 1.0 mg of tetracosactid (Synacthen®) was followed by a distinct increase of plasma growth hormone (GH) within 30 or 45 min in 5 of 7 normal volunteers. A second control test was performed in 3 of the 5 "responders" and 1 "non-responder" and showed a consistent reaction in all of them. The tests were then repeated in the 5 "responders" during an infusion of somatostatin (150 μg/h) and the GH response was totally abolished (3 subjects) or markedly reduced (2 subjects). Thus the ACTH induced GH release behaves in a manner similar to most other physiological or pharmacological stimuli of GH release. The cortisol output after ACTH was not altered by somatostatin.

THE EFFECT OF INTRAVENOUS L-DOPA ON GROWTH HORMONE AND LUTEINIZING HORMONE LEVELS IN MAN

1973 ◽  
Vol 73 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Athanasius Souvatzoglou ◽  
Klaus von Werder ◽  
Peter Bottermann
Keyword(s):  
Growth Hormone ◽  
Luteinizing Hormone ◽  
Normal Subjects ◽  
Serum Levels ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Serum Growth Hormone ◽  
Provocative Test ◽  
Hormone Levels ◽  
Serum Lh

ABSTRACT The effect of various intravenous doses of L-dopa on growth hormone and LH-serum levels in 25 normal subjects was investigated. Growth hormone increased 30–40 minutes following the injection of 25 mg and 100 mg L-dopa whereas doses of less than 25 mg had no significant effect on the serum growth hormone levels. The serum LH-level was not significantly altered by the intravenous administration of various doses (1 to 100 mg) of L-dopa. These findings, which are in agreement with the results obtained with L-dopa given orally, suggest that the intravenous injection of 25 mg L-dopa may be useful as a short provocative test for growth hormone release in man.

Sustained Exercise Increases Plasma Growth Hormone Concentrations in Two Anadromous Salmonids

1988 ◽  
Vol 45 (4) ◽  
pp. 747-749 ◽  
Author(s):  
Bruce A. Barrett ◽  
Brian A. McKeown
Keyword(s):  
Growth Hormone ◽  
Coho Salmon ◽  
Oncorhynchus Kisutch ◽  
Salmo Gairdneri ◽  
Steady Increase ◽  
Steelhead Trout ◽  
Plasma Growth Hormone ◽  
Plasma Gh

Sustained exercise for 24 h at 1.5 body lengths per second (bl/s) resulted in a severalfold increase in the plasma growth hormone (GH) concentration of steelhead trout (Salmo gairdneri) and coho salmon (Oncorhynchus kisutch). Peak levels occurred 10 min postexercise and returned to basal levels within 4 h of exercise termination. GH levels exhibited a steady increase after the fourth hour of exercise and peaked at 24 h. Individuals exercised for 48 h did not exceed plasma GH levels of the 24-h peak.

CELLULAR LOCALIZATION OF SOMATOSTATIN IN ENDOCRINE-LIKE CELLS AND NEURONS OF THE RAT WITH SPECIAL REFERENCES TO THE A1-CELLS OF THE PANCREATIC ISLETS AND TO THE HYPOTHALAMUS

1975 ◽  
Vol 80 (4_Suppl) ◽  
pp. S5-SNP ◽  
Author(s):  
Tomas Hökfelt ◽  
Suad Efendić ◽  
Claes Hellerström ◽  
Olle Johansson ◽  
Rolf Luft ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pancreatic Islets ◽  
Cellular Localization ◽  
Inhibitory Action ◽  
Nerve Fibers ◽  
Spinal Ganglia ◽  
Hormone Release ◽  
Growth Hormone Release ◽  
Control Serum ◽  
Number Of Cells

ABSTRACT With the indirect immunofluorescence technique somatostatin, a recently isolated and structurally characterized hypothalamic tetradecapeptide, which inhibits growth hormone release, has been traced in different tissues of the rat. Somatostatin or somatostatin-like immunoreactivity (SLI) was present in both neurons and endocrine-like cells. Somatostatin positive nerve cell bodies were observed in the periventricular region in the anterior parts of the hypothalamus and in probable nerve endings in the external and internal layer of the median eminence and in the pituitary stalk and in the ventromedial, arcuate and ventral premammillary nuclei and to a small extent in the periventricular region. Somatostatin positive nerve fibers were also found in the posterior pituitary, indicating the existence of a third neurosecretory hypothalamohypophysial system, and in nerves in different layers of the wall of the small and large intestine. These nerves may possibly be of sensory nature since some cell bodies of the spinal ganglia showed a weak immunofluorescence. Somatostatin or SLI was found in certain cells localized in the periphery of the pancreatic islets. In parallel studies with glucagon antibodies it could be established that the somatostatin positive cells and the glucagon positive cells were not identical but localized extremely close to each other. Furthermore, with the Hellman-Hellerström silver staining technique it could be shown that virtually all somatostatin cells are argyrophilic and vice versa. Somatostatin positive cells thus constitute the so-called A1-cells (D-cells). Glucagon positive cells, on the other hand, do in all probability not exhibit argyrophilia. The occurrence of probable somatostatin containing cells in the pancreatic islets is of special interest in view of several recent studies demonstrating an inhibitory action of this peptide on glucagon and insulin secretion. Somatostatin or SLI was found in a rather small number of cells in the thyroid gland with a parafollicular position. These cells exhibited a positive immunofluorescence also after pretreatment of the antiserum with calcitonin. Furthermore, endocrine-like cells in the stomach and in the intestine were also somatostatin positive. A large number of cells in various tissues, especially in the lamina propria of the gastro-intestinal tract, showed a strong fluorescence both after incubation with control serum and with FITC conjugated serum alone. The present results indicate that somatostatin or a somatostatin-like peptide(s), in addition to its inhibitory action on growth hormone release, may play a physiological role at many other levels of the organism.

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