Thyroid iodine and serum thyroid hormone levels in wild white-tailed deer (Odocoileus virginianus) from central Michigan

1983 ◽  
Vol 61 (5) ◽  
pp. 1116-1119 ◽  
Author(s):  
B. E. Watkins ◽  
D. E. Ullrey
Keyword(s):  
Body Weight ◽  
Odocoileus Virginianus ◽  
Wild Female ◽  
Complete Diet ◽  
Body Weights ◽  
Total Thyroxine ◽  
In The Wild ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Wild Deer

Three wild, female white-tailed deer (Odocoileus virginianus) collected in Missaukee County, Michigan, during February and March 1979 had lower (P < 0.01) serum total thyroxine (T4), free T4 (FT4), and triiodothyronine (T3) levels, thyroid iodine (I) concentration, and body weights than 17 captive does fed a complete diet. Thyroid weight per metabolic body weight (body weight (kilograms)0.75) was greater (P < 0.01) in the wild deer. These data indicate malnutrition and incipient I deficiency in the wild deer.

scholarly journals IFLUENCE OF AQUEOUS EXTRACT FROM FEIJOA LEAVES ON THYROID FUNCTION IN RATS WITH EXPERIMENTAL HYPOTHYROIDISM

2019 ◽  
Vol 3 ◽  
pp. 9-14
Author(s):  
Alevtyna Kononenko ◽  
Vera Kravchenko
Keyword(s):  
Body Weight ◽  
Thyroid Function ◽  
Aqueous Extract ◽  
Rectal Temperature ◽  
Albino Rats ◽  
Reference Drug ◽  
Functional Changes ◽  
Thyroid Mass ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels

The present work studied the effect of aqueous extract from Feijoa leaves on thyroid function of rats with experimental hypothyroidism. Healthy albino rats weighing between 120 gand 150 gwere used. The animals were randomly allotted into four groups, each containing eight rats respectively. Three of the groups (II, III and IV), induced with hypothyroidism, were treated by 0.05 % solution of thiamazole with drinking water for 30 days. Control (vehicle) rats were given normal saline. After 13 days hypothyroid groups (III and IV) of rats were treated with aqueous extract from Feijoa leaves at a dose 1.0 ml/100 g of body weight and with Iodomarin 200 (reference drug) at a dose 12 µg/kg daily orally for 21 days. Results obtained from the study showed that the introduction of thiamazole leads to functional changes in the thyroid gland in rats, accompanied by decreasing sings of rectal temperature and level of thyroid hormones. It was found, that treatment with AEFL normalizes serum thyroid hormone levels, increases rectal temperature and reduces the thyroid mass. The investigated extract can be attributed to the regulators of the thyroid hypofunction and is promising for further study of its effectiveness as a thyroid-stimulating agent.

Adaptation of wild-caught Tasmanian devils (Sarcophilus harrisii) to captivity: evidence from physical parameters and plasma cortisol concentrations

2005 ◽  
Vol 53 (5) ◽  
pp. 339 ◽  
Author(s):  
Susan M. Jones ◽  
Tammy J. Lockhart ◽  
Randolph W. Rose
Keyword(s):  
Body Weight ◽  
Plasma Cortisol ◽  
Physical Parameters ◽  
Elevated Plasma ◽  
Initial Sample ◽  
Body Weights ◽  
In Captivity ◽  
In The Wild ◽  
High Concentrations ◽  
Initial Capture

This study assessed whether capture and transferral into captivity represents a significant stressor to Tasmanian devils. Four male and four female devils were captured in the wild and housed for 6 months in captivity in male–female pairs. Blood samples were collected for cortisol assay at capture, every 24 h for the first 4 days, and then monthly; body weight and tail width were monitored weekly. In the males, mean plasma cortisol concentrations were highest (49 ± 9.19 ng mL–1) at the time of initial capture; cortisol concentrations declined significantly after 48 h in captivity (9.2 ± 5.96 ng mL–1) and did not change significantly over the months in captivity. Females exhibited a different pattern: plasma cortisol concentrations were highest (74.0 ± 3.24 ng mL–1) in the initial sample, but mean concentrations remained elevated in samples taken at 24, 48 and 96 h after initial capture, and did not exhibit a significant decline (to 20.65 ± 8.95 ng mL–1) until 4 weeks after capture. During the first 2 months in captivity, the male devils lost ~8.7% of their original body weight, and females lost 10.6% during this same period. However, body weights then rose during the rest of the experiment. These results suggest that Tasmanian devils experience elevated plasma cortisol concentrations in response to capture and transfer into captivity. However, these high concentrations are not maintained during 6 months in captivity, suggesting that the animals are not chronically stressed.

L-Ascorbic Acid Addition to Chitosan Reduces Body Weight in Overweight Women

2014 ◽  
Vol 84 (1-2) ◽  
pp. 5-11 ◽  
Author(s):  
Eun Y. Jung ◽  
Sung C. Jun ◽  
Un J. Chang ◽  
Hyung J. Suh
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Fat Body ◽  
Body Weight Gain ◽  
Skinfold Thickness ◽  
The Body ◽  
Control Group ◽  
Percentage Body Fat ◽  
Overweight Women ◽  
Body Weights

Previously, we have found that the addition of L-ascorbic acid to chitosan enhanced the reduction in body weight gain in guinea pigs fed a high-fat diet. We hypothesized that the addition of L-ascorbic acid to chitosan would accelerate the reduction of body weight in humans, similar to the animal model. Overweight subjects administered chitosan with or without L-ascorbic acid for 8 weeks, were assigned to three groups: Control group (N = 26, placebo, vehicle only), Chito group (N = 27, 3 g/day chitosan), and Chito-vita group (N = 27, 3 g/day chitosan plus 2 g/day L-ascorbic acid). The body weights and body mass index (BMI) of the Chito and Chito-vita groups decreased significantly (p < 0.05) compared to the Control group. The BMI of the Chito-vita group decreased significantly compared to the Chito group (Chito: -1.0 kg/m2 vs. Chito-vita: -1.6 kg/m2, p < 0.05). The results showed that the chitosan enhanced reduction of body weight and BMI was accentuated by the addition of L-ascorbic acid. The fat mass, percentage body fat, body circumference, and skinfold thickness in the Chito and Chito-vita groups decreased more than the Control group; however, these parameters were not significantly different between the three groups. Chitosan combined with L-ascorbic acid may be useful for controlling body weight.

Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY

2020 ◽  
Vol 20 (8) ◽  
pp. 1262-1267
Author(s):  
Haojun Yang ◽  
Hanyang Liu ◽  
YuWen Jiao ◽  
Jun Qian
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Metabolic Diseases ◽  
Peptide Yy ◽  
The Body ◽  
Wild Type ◽  
L Cells ◽  
Body Weights ◽  
Gastrointestinal Bypass ◽  
G Protein Coupled

Background: G protein-coupled bile acid receptor (TGR5) is involved in a number of metabolic diseases. The aim of this study was to identify the role of TGR5 after Roux-en-Y gastric bypass (GBP). Methods: Wild type and TGR5 knockout mice (tgr5-/-) were fed a high-fat diet (HFD) to establish the obesity model. GBP was performed. The changes in body weight and food intake were measured. The levels of TGR5 and peptide YY (PYY) were evaluated by RT-PCR, Western blot, and ELISA. Moreover, the L-cells were separated from wild type and tgr5-/- mice. The levels of PYY in L-cells were evaluated by ELISA. Results: The body weights were significantly decreased after GBP in wild type mice (p<0.05), but not tgr5-/- mice (p>0.05). Food intake was reduced after GBP in wild type mice, but also not significantly affected in tgr5-/- mice (p>0.05). The levels of PYY were significantly increased after GBP compared with the sham group (p<0.05); however, in tgr5-/- mice the expression of PYY was not significantly affected (p>0.05). After INT-777 stimulation in L-cells obtained from murine intestines, the levels of PYY were significantly increased in L-cells tgr5+/+ (p<0.05). Conclusion: Our study suggests that GBP up-regulated the expression of TGR5 in murine intestines, and increased the levels of PYY, which further reduced food intake and decreased the body weight.

scholarly journals A deep-learning method using computed tomography scout images for estimating patient body weight

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shota Ichikawa ◽  
Misaki Hamada ◽  
Hiroyuki Sugimori
Keyword(s):  
Computed Tomography ◽  
Body Weight ◽  
Deep Learning ◽  
Contrast Medium ◽  
Model Performance ◽  
Ct Scanning ◽  
Drug Dosing ◽  
Body Weights ◽  
Dose Management ◽  
Medium Dose

AbstractBody weight is an indispensable parameter for determination of contrast medium dose, appropriate drug dosing, or management of radiation dose. However, we cannot always determine the accurate patient body weight at the time of computed tomography (CT) scanning, especially in emergency care. Time-efficient methods to estimate body weight with high accuracy before diagnostic CT scans currently do not exist. In this study, on the basis of 1831 chest and 519 abdominal CT scout images with the corresponding body weights, we developed and evaluated deep-learning models capable of automatically predicting body weight from CT scout images. In the model performance assessment, there were strong correlations between the actual and predicted body weights in both chest (ρ = 0.947, p < 0.001) and abdominal datasets (ρ = 0.869, p < 0.001). The mean absolute errors were 2.75 kg and 4.77 kg for the chest and abdominal datasets, respectively. Our proposed method with deep learning is useful for estimating body weights from CT scout images with clinically acceptable accuracy and potentially could be useful for determining the contrast medium dose and CT dose management in adult patients with unknown body weight.

scholarly journals Effects of Daily Kelp (Laminaria japonica) Intake on Body Composition, Serum Lipid Levels, and Thyroid Hormone Levels in Healthy Japanese Adults: A Randomized, Double-Blind Study

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 352
Author(s):  
Seiichiro Aoe ◽  
Chiemi Yamanaka ◽  
Hirofumi Ohtoshi ◽  
Fumiko Nakamura ◽  
Suguru Fujiwara
Keyword(s):  
Thyroid Hormone ◽  
Body Fat ◽  
Laminaria Japonica ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Double Blind ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Male Subjects ◽  
Japanese Subjects

To investigate whether supplementation with iodine-reduced kelp (Laminaria japonica) powder decreases body fat composition in overweight Japanese subjects, a randomized, double-blind, placebo-controlled intervention study was conducted in 50 Japanese subjects with body mass index (BMI) ≥25 and <30 kg/m2. Subjects were randomly assigned to consume thirty tablets/d (10 tablets orally, 3 times/d) containing either iodine-reduced kelp powder (test, 6 g kelp powder corresponding to 3 g alginate/d) or kelp-free powder (placebo) for 8 weeks. Anthropometric measurements, blood lipids, and serum thyroid hormone levels were obtained before and after the trial. Body fat percentage was significantly decreased in male subjects from the test group compared with the placebo group. The same tendency was observed for body weight (p = 0.065) and BMI (p = 0.072) in male subjects. No significant changes in anthropometric measurements or visceral fat area were observed in female subjects. Serum thyroid hormone concentrations did not increase after 1.03 mg/d of iodine supplementation through kelp intake. The intake of iodine-reduced kelp powder led to significant and safe reductions in body fat percentage in overweight male subjects. The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.

scholarly journals CTNI-15. CLINICAL EFFICACY OF ONC201 IN NEWLY DIAGNOSED DIPG AND IN PREVIOUSLY IRRADIATED PEDIATRIC H3 K27M-MUTANT GLIOMAS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii45-ii45
Author(s):  
Sharon Gardner ◽  
Carl Koschmann ◽  
Rohinton S Tarapore ◽  
Jeffrey Allen ◽  
Wafik Zaky ◽  
...  
Keyword(s):  
Body Weight ◽  
Single Agent ◽  
Biologically Active ◽  
Pharmacokinetic Analysis ◽  
Low Grade ◽  
Newly Diagnosed ◽  
Liquid Formulation ◽  
Phase Ii Trials ◽  
Body Weights ◽  
Post Radiation

Abstract ONC201, an anti-cancer DRD2 antagonist and ClpP agonist, is in Phase II trials for adult H3 K27M-mutant diffuse midline gliomas. In adults, the recommended phase 2 dose (RP2D) of 625mg ONC201 once a week has been established as a biologically active dose that is well tolerated. Radiographic regressions with single agent ONC201 have been reported in adult recurrent H3 K27M-mutant glioma patients. This multi-arm, dose-escalation and dose-expansion trial determined the pediatric RP2D of ONC201 administered as an oral capsule (Arm A) or liquid formulation (Arm E) in post-radiation H3 K27M-mutant glioma (Arm A) or in newly diagnosed DIPG (Arm B) patients. Molecular assessments include intratumoral ONC201 concentrations (Arm C) and CSF H3 K27M DNA levels (Arm D). Enrollment as of April 30, 2020 is complete in Arm A (22) and Arm E (26) and continues in Arm B (18/24), Arm C (5/12), and Arm D (22/24). The RP2D of weekly 625mg ONC201 scaled by body weight was confirmed when administered as a capsule or a liquid formulation as a single agent or in combination with radiation without dose-limiting toxicity. The most frequent adverse events regardless of attribution to the drug were predominantly low grade: ONC201 capsule alone was headache (54.5%), nausea (36.4%), and fatigue (36.4%); ONC201 liquid formulation was vomiting (31.8%), headache (22.7%), VIth nerve disorder (22.7%); ONC201 capsules in combination with radiation (Arm B) was headache (47.1%), vomiting (52.9%), nausea (41.2%). Pharmacokinetic analysis in plasma of Arm A patients revealed T1/2: 8.4h; Tmax: 2.1h; Cmax: 2.3ug/mL; AUC0-tlast: 16.4ug/mL, with similar exposure across body weights. In conclusion, when scaled by body weight the ONC201 capsule or liquid formulation alone or in combination with radiation were associated with safety and pharmacokinetic profiles in pediatric H3 K27M-mutant diffuse midline glioma patients that are similar to the experience in adults.

scholarly journals 93 Evaluation of the intake and digestibility of ensiled residual material from edamame soybean processing with and without the use of an inoculant

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 74-74
Author(s):  
Ellen M Herring ◽  
Elizabeth B Kegley ◽  
Ken Coffey ◽  
Shane Gadberry ◽  
Jeremy G Powell ◽  
...  
Keyword(s):  
Body Weight ◽  
Average Daily Gain ◽  
Adaptation Period ◽  
Processing Waste ◽  
Mineral Supplement ◽  
Dry Matter Digestibility ◽  
Body Weights ◽  
Soybean Processing ◽  
Silage Inoculant ◽  
Daily Gain

Abstract This research evaluated the effects of ensiled edamame soybean processing waste on ruminant intake and total tract digestibility. Waste from processing stored edamame was obtained (3 trips) and wilted (28%, 25%, and 37% DM), then treated with or without inoculant (Lactobacillus buchneri) and ensiled in 167 L plastic barrels (2 or 3 barrels/treatment from each trip) for 72 (Trip 1) or 69 (Trip 2 and 3) days. Pregnant ewes (n = 18; body weight = 55.5 ± 1.2 kg; 2 to 3 years old) were blocked by body weight and assigned randomly within a block to treatments within a trip, then each ewe was assigned to a barrel of silage. Ewes were housed individually in 1 × 1.5-m pens and offered silage for a 10-day adaptation period followed by 7 days of total feces and urine collection. Ewes were offered silage to allow for 10% orts and were offered 0.2% of their body weight of soyhulls and 32 g of mineral supplement/day to meet their predicted nutrient requirements for gestating ewes. Ewes consumed 1,616 ± 54 g DM/day (X ± SEM) or 2.9 ± 0.12% of their body weight and there was no effect (P ≥ 0.85) of inoculant treatment on DM intake (g/day or % of body weight). Dry matter digestibility was not affected (P = 0.98) by inoculant and averaged 55.7 ± 0.66%. Ewe average daily gain for the 17-day trial tended to be greater (P = 0.08) for the ewes offered the silage without inoculant (0.18 vs. 0.04 kg/d). Ensiling edamame processing waste yielded a feed that ewes consumed in adequate amounts to maintain their body weights over 17 days when also supplemented with soyhulls. The addition of silage inoculant had minimal effects on intake, digestibility, or ewe body weight change.

Seasonal changes in pancreatic B-cell function in euthermic yellow-bellied marmots

1985 ◽  
Vol 249 (2) ◽  
pp. R159-R165 ◽  
Author(s):  
G. L. Florant ◽  
A. K. Lawrence ◽  
K. Williams ◽  
W. A. Bauman
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
B Cell ◽  
Cell Function ◽  
Peripheral Resistance ◽  
The Body ◽  
Pancreatic B Cell ◽  
Peripheral Insulin Resistance ◽  
Body Weights ◽  
System Input

Fasting plasma insulin (PI) and glucose (PG) concentrations were measured throughout the body weight cycle of marmots. Animals gained weight during summer, and in late fall body weight peaked, after which they ceased feeding. Each month euthermic animals were injected intra-arterially with either dextrose (500 mg/kg) or porcine insulin (0.1 U/kg), and blood samples were collected over the subsequent 2 h. During weight gain fasting PI concentration and pancreatic B-cell response to injected dextrose increased markedly. Maximal insulin release to a dextrose challenge was measured during peak body weight or when body weight initially began to decline. The PG concentration after exogenous insulin administration was slight (less than 10%) in the fall but increased approximately 25% in the spring after marmots lost weight. Basal PG levels were not significantly different throughout the year. Basal fasting PI concentrations were significantly higher during the fall (P less than 0.01). It is suggested that in the fall, when marmots are obese, hyperinsulinemia and peripheral insulin resistance appear. Furthermore, in two animals with an increase in body weight of approximately 30% or less over the summer, peripheral resistance was demonstrable, albeit not as marked as in animals that appropriately doubled their body weights when given food ad libitum. Thus we hypothesize that factors other than adiposity, i.e., food intake, central nervous system input to the pancreatic B-cell, and/or changes in B-cell sensitivity to PG, may contribute to the observed peripheral insulin resistance and may be involved in body weight regulation.

GROWTH, PRODUCTION AND REPRODUCTION CHARACTERISTICS OF THE CANADIAN BREED OF CATTLE AND ITS FIRST CROSS AND BACKCROSS WITH THE BROWN SWISS. I. BODY WEIGHTS AND DIMENSIONS

1981 ◽  
Vol 61 (4) ◽  
pp. 853-860
Author(s):  
DOMINIQUE D. RONY ◽  
MOHAMED H. FAHMY ◽  
WILFRIED B. HOLTMANN
Keyword(s):  
Body Weight ◽  
Body Length ◽  
Season Of Birth ◽  
Body Dimensions ◽  
Brown Swiss ◽  
Body Weights ◽  
Growth Production

Body weight and seven body dimensions measuring the length, height, width and depth were taken at birth and every 180 days up to 720 days of age on 49 pure Canadian, 49 first cross of 1/2 Brown Swiss 1/2 Canadian, and 30 backcross of 1/4 Brown Swiss 3/4 Canadian heifers. The animals were raised up to 180 days of age at the Deschambault Station, then half the pure Canadian and the first cross were transferred to the La Pocatière Station. At birth, the pure Canadian calves weighed 29.2 kg and were lighter than the first and backcrosses by 6.9 kg (24%) and 4.8 kg (16%), respectively. The two crosses exceeded the pure Canadian in all the dimensions, the differences being significant in height at shoulder and width at rumps. At 360 days of age the two crosses were about 6% heavier and 4% higher at shoulder than the pure Canadian. With the exception of body length after 1 yr of age in which the backcross was slightly inferior to the pure Canadian, the two crosses were generally larger than the pure Canadian, with the backcross being intermediate between the first cross and the pure Canadian. The effects of season of birth and age of dam were found to be non-significant on most of the traits studied in this experiment.

Sign in / Sign up

Export Citation Format

Share Document