Effects of sex steroids on plasma lipids in the goldfish, Carassius auratus

1980 ◽  
Vol 58 (6) ◽  
pp. 967-972 ◽  
Author(s):  
Murray D. Wiegand ◽  
R. E. Peter
Keyword(s):  
Sex Steroids ◽  
Carassius Auratus ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Plasma Triglyceride ◽  
Control Fish ◽  
Warm Temperature ◽  
Plasma Total Cholesterol ◽  
Goldfish Carassius Auratus ◽  
Phosphorus Levels

The effects of sex steroids on plasma lipids in female goldfish were studied in sexually regressed and maturing fish at 12 °C, and in recent postovulatory-regressed fish at 21 °C. Intraperitoneal injection of oestrone (E1), but not oestradiol (E2), raised plasma triglyceride (TG) concentrations in regressed fish, but oestrogen had no effect on plasma TG in either maturing fish at 12 °C or in recent postovulatory–regressed fish at 21 °C. Progesterone injection caused high levels of plasma TG in maturing fish at 12 °C. Fish injected with E1or E2 had higher plasma total cholesterol (TC) levels posttreatment compared with control fish in both experiments at 12 °C, but E1 and E2 were without effect on plasma TC at 21 °C. Both E1 and E2 raised plasma lipid phosphorus levels in all three experiments. Testosterone generally had little effect on plasma lipids. These results support the hypothesis that oestrogen is involved in lipid mobilization in teleosts, and it appears that this effect is sensitive to warm temperature. There was no support for a mammalian-like, progesterone-stimulated system for clearance of plasma TG in the female goldfish.

Effects of salmon gonadotrophin (SG-G100) on plasma lipids in the goldfish, Carassius auratus

1980 ◽  
Vol 58 (6) ◽  
pp. 957-966 ◽  
Author(s):  
Murray D. Wiegand ◽  
R. E. Peter
Keyword(s):  
Blood Sample ◽  
Carassius Auratus ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Sexual Cycle ◽  
Control Solution ◽  
Goldfish Carassius Auratus ◽  
Ovarian Size ◽  
Mature Fish ◽  
Sexually Mature

Female goldfish were held under conditions of 12 °C and a 12 h light: 12 h dark photoperiod during three phases of the sexual cycle. A pretreatment blood sample was taken after 2 weeks of acclimation. Comparison of pretreatment levels of plasma lipids from the three experiments revealed that the concentration of triglycerides (TG) increased and total cholesterol (TC) decreased with increasing ovarian size. Plasma lipid phosphorus (LP) levels were slightly higher in sexually mature fish than in sexually regressed fish. Two weeks after the pretreatment blood sample, the fish were injected intraperitoneally with salmon gonadotrophin (SG-G100) or control solution for 3 days, after which a posttreatment blood sample was taken. In sexually maturing fish injection of SG-G100 caused increased plasma TG levels (compared with pretreatment) in fish with small ovaries, changing to decreased levels in fish with larger ovaries. A similar effect was also seen in maturing fish with plasma TC; these effects were abolished by castration or by keeping fish at 21 °C. SG-G100 had little effect on plasma LP. The results suggest that gonadotrophin causes a net mobilization of lipid in fish with small ovaries (presumably via sex steroids) and accelerated ovarian uptake of lipid in fish with larger ovaries.

scholarly journals The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Shuxia Wang ◽  
Kangxing Song ◽  
Roshni Srivastava ◽  
Mohsen Fathzadeh ◽  
Na Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Plasma Lipids ◽  
Meta Analysis ◽  
Plasma Lipid ◽  
Recessive Model ◽  
Plasma Triglyceride ◽  
Recessive Homozygote ◽  
Tcf7l2 Variant

Background. The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.Methods. We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized.Results. 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = −0.04, 95% CI (−0.08, 0.00),P= 0.048,Pheterogeneity= 0.47; recessive model: SMD = −0.10, 95% CI (−0.18, −0.02),P= 0.01,Pheterogeneity= 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.Conclusions. Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.

Effects of hypoxia, anoxia, and endogenous ethanol on thermoregulation in goldfish, Carassius auratus

2000 ◽  
Vol 278 (3) ◽  
pp. R545-R555 ◽  
Author(s):  
Richard N. Rausch ◽  
Larry I. Crawshaw ◽  
Helen L. Wallace
Keyword(s):  
Carassius Auratus ◽  
Response Pattern ◽  
Threshold Value ◽  
Control Fish ◽  
Similar Response ◽  
Brain Oxygen ◽  
Goldfish Carassius Auratus ◽  
Endogenous Ethanol ◽  
Ambient Oxygen ◽  
Normoxic Control

Effects of hypoxia, anoxia, and endogenous ethanol (EtOH) on selected temperature (Tsel) and activity in goldfish were evaluated. Blood and brain EtOH concentrations ([EtOH]) and brain oxygen partial pressure ([Formula: see text]) were quantified at crucial ambient oxygen pressures. Below a threshold value near 31 Torr, Tsel decreased as a function of environmental[Formula: see text]. Tsel of 15°C-acclimated fish was ∼10°C at the onset of anoxia and changed little over 2 h. Activity showed a similar response pattern. Brain [EtOH] was significantly elevated above control levels after 1 h anoxia. In normoxic water, Tsel remained different in previously anoxic and normoxic control fish for ∼20 min. Blood [EtOH] of previously anoxic fish remained significantly elevated ([EtOH] >4.0 μmol/g blood), and activity was significantly depressed at 20 min. Brain[Formula: see text] reached normal levels in <3 min. We conclude that [EtOH] (brain or blood) and brain[Formula: see text] are not proximal causes of either behavioral anapyrexia (hypothermia) or inactivity in goldfish exposed to oxygen-depleted environments.

Diel cyclic hypoxia alters plasma lipid dynamics and impairs reproduction in goldfish (Carassius auratus)

2017 ◽  
Vol 43 (6) ◽  
pp. 1677-1688 ◽  
Author(s):  
Aritra Bera ◽  
Paramita Banerjee Sawant ◽  
Subrata Dasgupta ◽  
N. K. Chadha ◽  
Bhawesh T. Sawant ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Plasma Lipid ◽  
Goldfish Carassius Auratus ◽  
Lipid Dynamics

Effects of sex steroids on the mRNA levels of gonadotropin subunits in juvenile and ovariectomized goldfish Carassius auratus

2000 ◽  
Vol 66 (2) ◽  
pp. 223-231 ◽  
Author(s):  
M AKITO KOBAYASHI ◽  
Y OUNG C HANG SOHN ◽  
Y ASUTOSHI YOSHIURA ◽  
K ATSUMI AIDA
Keyword(s):  
Sex Steroids ◽  
Carassius Auratus ◽  
Mrna Levels ◽  
Goldfish Carassius Auratus

scholarly journals A comparison of the influence on plasma lipids and platelet function of supplements of ω3 and ω6 polyunsaturated fatty acids

1983 ◽  
Vol 50 (3) ◽  
pp. 521-529 ◽  
Author(s):  
T. A. B. Sanders ◽  
Michele C. Hochland
Keyword(s):  
Platelet Aggregation ◽  
Vegetable Oil ◽  
Crossover Trial ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Plasma Total Cholesterol ◽  
Double Blind ◽  
Plasma Triglycerides ◽  
Platelet Thromboxane

1. A randomized double-blind crossover trial was carried out to compare the influence on plasma lipid concentrations, platelet thromboxane B2production and platelet aggregation induced by ADP, collagen and U46619 (a prostaglandin endoperoxide analogue), of a daily 10 g supplement of a fish-oil concentrate (MaxEPA), which provided (g): 1·7 20:5ω3, 0·3 22:5ω3 and 1·2 22:6ω3, taken for 2 weeks by ten healthy subjects, with one of vegetable oil providing 3·4 18:2ω6.2. A lower response to platelet aggregation induced by 0·5 μg collagen/ml but not by other aggregating agents was observed following both types of supplement. Platelet thromboxane B2production induced by collagen also tended to be lower following the supplements.3. Plasma total cholesterol concentrations were unaffected by the supplements. The MaxEPA but not the vegetable-oil supplement lowered the concentration of plasma triglycerides and increased that of high-density-lipoprotein-cholesterol.

Effects of thyroxine administration on plasma thyroxine levels in the goldfish, Carassius auratus L.

1977 ◽  
Vol 55 (1) ◽  
pp. 255-258 ◽  
Author(s):  
Mary E. Hurlburt
Keyword(s):  
Carassius Auratus ◽  
Control Fish ◽  
Goldfish Carassius Auratus ◽  
Treated Fish

Pellet implantation, immersion, or feeding of thyroxine (T4) raised plasma T4 levels above values of control fish (usually less than 1 μg/100 ml). Values for treated fish in the lower dosage groups generally fell between 1 and 4 μg/100 ml, while in the higher dosage groups plasma T4 levels ranged from 5 to 16 μg/100 ml.

Plasma lipids, lipoproteins, and triglyceride turnover in eu- and hypo-thyroid rats and rats on a hypocaloric diet

1981 ◽  
Vol 59 (8) ◽  
pp. 715-721 ◽  
Author(s):  
Ladislav Dory ◽  
Brian R. Krause ◽  
Paul S. Roheim
Keyword(s):  
Half Life ◽  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Low Density Lipoprotein ◽  
Caloric Intake ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Plasma Triglyceride ◽  
Low Density ◽  
Control Groups

Lipid and lipoprotein concentration, and triglyceride turnover were studied in control, thyroidectomized, and pair-fed control rats (pair-fed to match the food intake of the thyroidectomized rats). Thyroidectomy induced a significant increase in plasma cholesterol (and low density lipoprotein) concentrations and a decrease in plasma triglyceride (and very low density lipoprotein) concentrations. Changes in similar direction but of smaller magnitude were observed in the plasma of the pair-fed control rats. To further investigate triglyceride metabolism in these three groups of animals, triglyceride turnover was studied in fasted, unrestrained, and unanesthetized rats, following injection of [2-3H]glycerol. Peak incorporation of [2-3H]glycerol into plasma triglyceride occurred in all three groups of animals at 25 min after precursor administration, although the maximal incorporation was substantially lower in the thyroidectomized group than in either of the control groups. Thereafter, plasma triglyceride radioactivity decayed monoexponentially with a half-life of 24 ± 1 min for both normal and pair-fed control rats, compared with the half-life of 41 ± 3 min observed in the thyroidectomized rats. The calculated apparent fractional catabolic rates were thus 0.029 min−1 for both control groups and only 0.017 min−1 for the thyroidectomized animals. The apparent total catabolic rates of plasma triglyceride were 299 ± 11, 138 ± 11, and 48 ± 4 μg triglyceride∙min−1 for the normal controls, pair-fed controls, and thyroidectomized rats, respectively. These data further emphasize the importance of thyroid hormones in regulating plasma lipid and lipoprotein metabolism and, specifically, indicate that hypothyroidism results in a reduction of triglyceride secretion into, and the removal from, circulation. Furthermore, evidence was presented that the decreased caloric intake of the hypothyroid animals cannot, in itself, account for this observation.

Sign in / Sign up

Export Citation Format

Share Document