INFLUENCE DU DÉRIVÉ CYANURÉ DU DDT SUR LE RYTHME CARDIAQUE DE PERIPLANETA AMERICANA (L.)
The mode of action, on the heart of Periplaneta americana, of the cyanide analogue of DDT has been studied. Results of preliminary tests with rotenone confirm the findings of other investigators. Tests made with DDT produce a slight reduction of the cardiac rhythm. With the cyanide analogue of DDT, the rate of heart beat is also slightly reduced but, as with DDT, the pulsations continue long after paralysis has set in. The general intoxication symptoms produced by the injection of the cyanide analogue (in suspension) are likewise identical with those of DDT. The above results, together with results of experiments found in the literature, seem to be at variance with the hypothesis proposed by Krijgsman et al. that the heart mechanism of insects consists of a neurogenic pacemaker with adrenergic properties, controlled by a cholinergic accelerating nerve.