Age-dependent metabolic effects of repeated hypoxemia in piglets

2000 ◽  
Vol 78 (4) ◽  
pp. 321-328 ◽  
Author(s):  
Aurore Côté ◽  
Jill Barter ◽  
Brian Meehan
Keyword(s):  
Lactic Acid ◽  
Body Temperature ◽  
Metabolic Rate ◽  
Cardiovascular Response ◽  
Alveolar Ventilation ◽  
Repeated Exposure ◽  
Metabolic Effects ◽  
Age Dependent ◽  
Lactate Levels ◽  
Over Time

The aim of this study was to determine whether repeated exposure to hypoxemia would modify the response to hypoxemia during maturation. We exposed piglets to three 1-h cycles of hypoxemia (PaO2 = 30 to 35 mmHg; 1 mmHg = 133.3 Pa) at 1 week (n = 9), 2-3 weeks (n = 10), and 4-5 weeks of age (n = 10). O2 consumption (VO2) and CO2 production (VCO2) were measured, and alveolar ventilation (VA) was derived from VCO2 and PaCO2. Levels of lactic acid (lactate) and serum catecholamines were also measured. With hypoxemia, time had a significant effect on VO2 and body temperature in an age-dependent fashion: that is, whereas the 1 week group and the 4-5 week group showed both variables decreasing over time, the 2-3 week group showed no drop in VO2 and a small increase in body temperature over time. Lactate levels increased with hypoxemia in all animals during the first exposure. However, with repeated exposures to hypoxemia, only the 2-3 week group continued to increase its lactate levels. Furthermore, the changes in lactate levels paralleled the changes in epinephrine levels with hypoxemia. We found, too, that although VA increased significantly with hypoxemia in all animals, this change was not modified by age or repeated exposures. No significant effects of age or repeated exposures were found in the cardiovascular response to hypoxemia. We concluded that, from a metabolic viewpoint, after repeated exposures to hypoxemia the 2-3 week animals responded differently.Key words: metabolic rate, lactic acid, maturation, catecholamines.

scholarly journals The decoupled nature of basal metabolic rate and body temperature in endotherm evolution

Nature ◽  
2019 ◽  
Vol 572 (7771) ◽  
pp. 651-654 ◽  
Author(s):  
Jorge Avaria-Llautureo ◽  
Cristián E. Hernández ◽  
Enrique Rodríguez-Serrano ◽  
Chris Venditti
Keyword(s):  
Body Temperature ◽  
Metabolic Rate ◽  
Basal Metabolic Rate

Relationship between metabolic rate and core body temperature during sleep in human

2015 ◽  
Vol 16 ◽  
pp. S186-S187 ◽  
Author(s):  
I. Park ◽  
M. Kayaba ◽  
K. Iwayama ◽  
H. Ogata ◽  
Y. Sengoku ◽  
...  
Keyword(s):  
Body Temperature ◽  
Metabolic Rate ◽  
Core Body Temperature ◽  
Core Body

The response of the kidney of the freshwater rainbow trout to true metabolic acidosis

1980 ◽  
Vol 84 (1) ◽  
pp. 227-244 ◽  
Author(s):  
K. A. Kobayashi ◽  
C. M. Wood
Keyword(s):  
Lactic Acid ◽  
Metabolic Acidosis ◽  
Blood Lactate ◽  
Renal Excretion ◽  
Total Acid ◽  
Time Courses ◽  
Lactate Levels ◽  
Urinary Acid ◽  
Proton Load ◽  
Lactate Excretion

Infusion of lactic acid into the bloodstream of trout produced a short-lived depression of blood pH and a long-lasting elevation of blood lactate. The lactate injected was distributed in a volume of 198 ml/kg. Renal excretion of lactate anion and total acid increased by approximately equal amounts during the period of high blood lactate levels, but total renal loss over 72 h accounted for only 2% of the lactate load and 6% of the proton load. Comparable differences in the time courses of blood lactate and pH changes occurred when lactacidosis was induced endogenously by normocapnic hypoxia. The immediate response of the kidney was similar to that with lactic acid infusion, but there was a long-lasting (12–72 + h) elevation of urinary acid efflux that was not associated with lactate excretion. Following hypoxia, renal excretion over 72 h accounted for 1% of the estimated lactate load and 12–25% of the proton load. A renal lactate threshold of 4–10 muequiv/ml prevents significant urinary lactate excretion. The response of the trout kidney to true metabolic acidosis is similar to that of the mammalian kidney.

On the Regulation of the Respiration in Reptiles

1961 ◽  
Vol 38 (2) ◽  
pp. 301-314 ◽  
Author(s):  
BODIL NIELSEN
Keyword(s):  
Steady State ◽  
Body Temperature ◽  
Metabolic Rate ◽  
Temperature Interval ◽  
Normal Values ◽  
Pulmonary Ventilation ◽  
The Body ◽  
Respiratory Frequency ◽  
Temperature Changes ◽  
Instantaneous Increase

1. In two species of Lacerta (L. viridis and L. sicula) the effects on respiration of body temperature (changes in metabolic rate) and of CO2 added to the inspired air were studied. 2. Pulmonary ventilation increases when body temperature increases. The increase is brought about by an increase in respiratory frequency. No relationship is found between respiratory depth and temperature. 3. The rise in ventilation is provoked by the needs of metabolism and is not established for temperature regulating purposes (in the temperature interval 10°-35°C). 4. The ventilation per litre O2 consumed has a high numerical value (about 75, compared to about 20 in man). It varies with the body temperature and demonstrates that the inspired air is better utilized at the higher temperatures. 5. Pulmonary ventilation increases with increasing CO2 percentages in the inspired air between o and 3%. At further increases in the CO2 percentage (3-13.5%) it decreases again. 6. At each CO2 percentage the pulmonary ventilation reaches a steady state after some time (10-60 min.) and is then unchanged over prolonged periods (1 hr.). 7. The respiratory frequency in the steady state decreases with increasing CO2 percentages. The respiratory depth in the steady state increases with increasing CO2 percentages. This effect of CO2 breathing is not influenced by a change in body temperature from 20° to 30°C. 8. Respiration is periodically inhibited by CO2 percentages above 4%. This inhibition, causing a Cheyne-Stokes-like respiration, ceases after a certain time, proportional to the CO2 percentage (1 hr. at 8-13% CO2), and respiration becomes regular (steady state). Shift to room air breathing causes an instantaneous increase in frequency to well above the normal value followed by a gradual decrease to normal values. 9. The nature of the CO2 effect on respiratory frequency and respiratory depth is discussed, considering both chemoreceptor and humoral mechanisms.

The liver proteome response to torpor in a basoendothermic mammal, Tenrec ecaudatus, provides insights into the evolution of homeothermy

2021 ◽  
Author(s):  
Jane I Khudyakov ◽  
Michael D Treat ◽  
Mikayla C Shanafelt ◽  
Jared S Deyarmin ◽  
Benjamin A Neely ◽  
...  
Keyword(s):  
Body Temperature ◽  
Metabolic Rate ◽  
Metabolic Pathways ◽  
Molecular Basis ◽  
Protein Abundance ◽  
Poor Control ◽  
High Body ◽  
Liver Proteome ◽  
The Common

Many mammals use adaptive heterothermy (e.g. torpor, hibernation) to reduce metabolic demands of maintaining high body temperature (Tb). Torpor is typically characterized by coordinated declines in Tb and metabolic rate (MR) followed by active rewarming. Most hibernators experience periods of euthermy between bouts of torpor during which homeostatic processes are restored. In contrast, the common tenrec, a basoendothermic Afrotherian mammal, hibernates without interbout arousals and displays extreme flexibility in Tb and MR. We investigated the molecular basis of this plasticity in tenrecs by profiling the liver proteome of animals that were active or torpid with high and more stable Tb (~32°C) or lower Tb (~14°C). We identified 768 tenrec liver proteins, of which 50.9% were differentially abundant between torpid and active animals. Protein abundance was significantly more variable in active cold and torpid compared to active warm animals, suggesting poor control of proteome abundance. Our data suggest that torpor in tenrecs may lead to mismatches in protein pools due to poor coordination of anabolic and catabolic processes. We propose that the evolution of endothermy leading to a more realized homeothermy of boreoeutherians likely led to greater coordination of homeostatic processes and reduced mismatches in thermal sensitivities of metabolic pathways.

CHARACTERISTICS OF AGE-DEPENDENT CHANGES IN THE URINE'S PROTEOM COMPOSITION OF THE HEALTHY PERSONS (EXPERIMENTAL AND THEORETICAL STUDY)

2020 ◽  
pp. 735-740
Author(s):  
Л. Х. Пастушкова ◽  
Д. Н. Каширина ◽  
А. Г. Гончарова ◽  
Н. Б. Захарова ◽  
Е. С. Тийс ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Insulin Signaling ◽  
Defense Mechanisms ◽  
Theoretical Study ◽  
Clinical Manifestations ◽  
Age Dependent ◽  
First Time ◽  
Healthy Persons ◽  
Over Time

Впервые описаны белки, достоверно увеличивающиеся и уменьшающиеся в моче с возрастом в интервале 20-60 лет. Охарактеризованы комбинации белков, связанных с изменением иммунных процессов, нарушением реологии крови, в том числе риском коагулопатии, противоопухолевых защитных механизмов, инсулинового сигнального пути, с изменением характеристик клеточного деления и качества новообразованной ткани. Таким образом, возрастная динамика основных процессов запускает каскад реакций, проявляющихся в замыкании «патологических биохимических кругов», которые формируют предпосылки к развитию заболеваний и, с течением времени, клинические проявления. For the first time proteins are described, reliably increasing and decreasing in urine with age in the range of 20 to 60 years. The combinations of proteins associated with changes in immune processes, violation of blood reology, including the risk of coagulopathy, anticancer defense mechanisms, insulin signaling pathway, changes in cell characteristics are characterized division and quality of the newly formed fabric. Thus, the age dynamics of the main processes triggers a cascade of reactions manifested in the closure of «pathological biochemical circles» that form the prerequisites for the development of diseases and, over time, clinical manifestations.

Relation of Hypoxemia and/or Hypocapnia to Lactic Acid Content of Brain and Cardiovascular Response

1958 ◽  
Vol 193 (2) ◽  
pp. 345-349 ◽  
Author(s):  
Clyde Biddulph ◽  
Donald D. Van Fossan ◽  
Dominic Criscuolo ◽  
Robert T. Clark
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Lactic Acid ◽  
Cardiovascular Response ◽  
Control Level ◽  
Tissue Level ◽  
Chemical Analyses ◽  
Lactic Acid Concentration ◽  
Determining Factors ◽  
Lactic Acid Content

The lactic acid concentration of brain was measured 3 hours after death in dogs which had been subject to hypocapnia, hypoxemia with hypocapnia, and hypoxemia without hypocapnia for 15 minutes. There was no elevation of brain lactic acid above the control level in those dogs subjected to hypocapnia or hypoxemia alone, however, when hypocapnia and hypoxemia were combined there was a significant increase. Cardiovascular and blood chemical analyses support the conclusion that variations in cerebral blood flow, availability of oxygen at the tissue level and interference with oxidative metabolism are important determining factors in brain lactic acid build-up. The results agree with those obtained in altitude-exposed animals, for they likewise show an elevation of brain lactic acid.

scholarly journals Effects of exercise on plasma lactic acid and body temperature in man, following a standardized meal

2018 ◽  
Vol 17 (2) ◽  
pp. 270-274
Author(s):  
Tesleem K Babalola ◽  
Udoh Utibe Abasi
Keyword(s):  
Lactic Acid ◽  
Body Temperature ◽  
Statistical Tests ◽  
Medical Science ◽  
Lactate Concentration ◽  
Bicycle Ergometer ◽  
Mean Value ◽  
Plasma Lactate ◽  
Post Exercise ◽  
Before And After

Background: The effects of exercise on plasma lactic acid level and body temperature following a standardized meal were carried out on 20 healthy young individuals (aged between 18 and 29 yrs.), consisting of 10 males and 10 females. The physical fitness of the subjects was determined measuring their blood pressure, pulse rate and other physical examinations.Methodology: Each subject was made to ride the bicycle ergometer for 6mins, at a rhythmic cadence of 50revolution/ min via 100beats metronome counts. Blood samples were collected before and after the exercise to analyze for the pre and post exercise plasma lactate levels. Pre and post-exercise values for body temperature were also measured. Statistical tests were carried out at 95% CI (P=0.05).Result: The result obtained showed that exercise causes a statistically significant increase (p< 0.05) in both plasma lactate concentration (from a pre-exercise mean value of 0.98 ±0.07mmol/L to post- exercise mean value of 2.84 ±0.21mmol/L) and body temperature (from a mean value of 36.45 ±0.130C before exercise to a mean value of 36.91 ±0.190C after exercise).Conclusion: There was a statistically significant increase in plasma lactateand body temperature because of exposure to exercise which is in line with findings from most previous studies.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.270-274

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