A tribute to the late Hans W. Kosterlitz: Ploughing the lone furrow

1998 ◽  
Vol 76 (3) ◽  
pp. 244-251 ◽  
Author(s):  
Gordon M Lees
Keyword(s):  
Dietary Protein ◽  
Protein Intake ◽  
Endogenous Opioid Peptides ◽  
Major Research ◽  
Research Topics ◽  
Endogenous Opioid ◽  
Narcotic Analgesics ◽  
Lasting Impression ◽  
Deep Sense ◽  
Enteric Reflexes

Hans Kosterlitz was a quiet, rather modest man, who was greatly respected, both as a scientist and as a person of real courage, honour, judgement, polite manners, and inflexible integrity of conduct and consistency of principle. His deep sense of social responsibility and his concern about making a worthwhile contribution for the benefit of mankind were reflected in his choice of research topics, in a career spanning more than 65 years. His major research interests were also exceptionally wide ranging, in terms of both subject matter and methodology. His first focus was the biochemistry of carbohydrate metabolism in diabetes mellitus and influence of dietary protein intake on the liver, then the physiology and pharmacology of enteric reflexes. It is his pioneering work on pharmacology of the narcotic analgesics and multiple opioid receptors and his illuminating concept, and subsequent discovery (in his eighth decade of life), of the occurrence of endogenous opioid peptides with which his name will be forever most closely linked. His infectious enthusiasm and zest for life made a lasting impression on everyone who met him, no matter how briefly. He was an inspiring teacher with a particular rapport with young scientists.

Types of opioid receptors: relation to antinociception

1985 ◽  
Vol 308 (1136) ◽  
pp. 291-297 ◽  
Keyword(s):  
Nervous System ◽  
Opioid Receptors ◽  
Opioid Peptides ◽  
Binding Sites ◽  
Endogenous Opioid Peptides ◽  
Endogenous Opioid ◽  
Narcotic Analgesics ◽  
High Concentrations ◽  
P Type ◽  
Μ Receptor

The endogenous opioid peptides are derived from three large precursors. Pro-opiocortin and proenkephalin yield [Met]enkephalin, carboxy-extended [Met]enkephalins and [Leu]enkephalin. The fragments of prodynorphin are all carboxy-extended [Leu]- enkephalins. Three approaches are of importance for an analysis of the physiological functions of the different endogenous opioid peptides. First, since these peptides interact with more than one of the μ-, δ- and K-binding sites and thus with their receptors, it is necessary to synthesize peptides or non-peptides, which bind to only one of the sites. As far as narcotic analgesics are concerned, morphine fulfils these conditions since it interacts almost exclusively with the μ-receptor. Secondly, antagonists are required that are selective for only one of the opioid receptors, even when used in high concentrations. Finally, it is important to find circumscribed areas in the nervous system that possess only one type of opioid receptor. It is now known that in the rabbit cerebellum the opioid receptors are almost exclusively of the p-type whereas in the guinea-pig cerebellum they are almost exclusively of the K-type.

Association between lean mass and dietary protein intake in postmenopausal women

2016 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliia Dzerovych ◽  
Roksolana Povorooznyuk
Keyword(s):  
Postmenopausal Women ◽  
Lean Mass ◽  
Dietary Protein ◽  
Protein Intake ◽  
Dietary Protein Intake

scholarly journals Dietary Intake, Nutritional Adequacy, and Food Sources of Protein and Relationships with Personal and Family Factors in Spanish Children Aged One to < 10 Years: Findings of the EsNuPI Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1062
Author(s):  
Casandra Madrigal ◽  
María José Soto-Méndez ◽  
Ángela Hernández-Ruiz ◽  
Teresa Valero ◽  
Federico Lara Villoslada ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Total Protein ◽  
Dairy Products ◽  
Protein Intake ◽  
Meat Products ◽  
Food Sources ◽  
Animal Origin ◽  
Total Protein Intake ◽  
Fish And Shellfish ◽  
Milk And Dairy Products

Diet in the first years of life is an important factor in growth and development. Dietary protein is a critical macronutrient that provides both essential and nonessential amino acids required for sustaining all body functions and procedures, providing the structural basis to maintain life and healthy development and growth in children. In this study, our aim was to describe the total protein intake, type and food sources of protein, the adequacy to the Population Reference Intake (PRI) for protein by the European Food Safety Authority (EFSA), and the Recommended Dietary Allowance (RDA) by the Institute of Medicine (IoM). Furthermore, we analyzed whether the consumption of dairy products (including regular milk, dairy products, or adapted milk formulas) is associated with nutrient adequacy and the contribution of protein to diet and whole dietary profile in the two cohorts of the EsNuPI (in English, Nutritional Study in the Spanish Pediatric Population) study; one cohort was representative of the Spanish population from one to < 10 years old (n = 707) (Spanish reference cohort, SRS) who reported consuming all kinds of milk and one was a cohort of the same age who reported consuming adapted milk over the last year (including follow-on formula, growing up milk, toddler’s milk, and enriched and fortified milks) (n = 741) (adapted milk consumers cohort, AMS). The children of both cohorts had a high contribution from protein to total energy intake (16.79% SRS and 15.63% AMS) and a high total protein intake (60.89 g/day SRS and 53.43 g/day AMS). We observed that protein intake in Spanish children aged one to < 10 years old was above the European and international recommendations, as well as the recommended percentages for energy intakes. The main protein sources were milk and dairy products (28% SRS and 29% AMS) and meat and meat products (27% SRS and 26% AMS), followed by cereals (16% SRS and 15% AMS), fish and shellfish (8% in both cohorts), eggs (5% SRS and 6% AMS), and legumes (4% in both cohorts). In our study population, protein intake was mainly from an animal origin (meat and meat products, milk and dairy products, fish and shellfish, and eggs) rather than from a plant origin (cereals and legumes). Future studies should investigate the long-term effect of dietary protein in early childhood on growth and body composition, and whether high protein intake affects health later in life.

scholarly journals Dietary Protein Intake and Overall Diet Quality are Associated with Handgrip Strength in African American and White Adults

2018 ◽  
Vol 22 (6) ◽  
pp. 700-709 ◽  
Author(s):  
Marie Fanelli Kuczmarski ◽  
R. T. Pohlig ◽  
E. Stave Shupe ◽  
A. B. Zonderman ◽  
M. K. Evans
Keyword(s):  
African American ◽  
Diet Quality ◽  
Dietary Protein ◽  
Protein Intake ◽  
Handgrip Strength ◽  
Dietary Protein Intake ◽  
White Adults

scholarly journals Higher maternal dietary protein intake in late pregnancy is associated with a lower infant ponderal index at birth

2006 ◽  
Vol 61 (4) ◽  
pp. 498-508 ◽  
Author(s):  
K Andreasyan ◽  
A-L Ponsonby ◽  
T Dwyer ◽  
R Morley ◽  
M Riley ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Protein Intake ◽  
Late Pregnancy ◽  
Ponderal Index ◽  
Dietary Protein Intake
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