Stimulation of brown adipose tissue activity in tumor-bearing rats

1995 ◽  
Vol 73 (11) ◽  
pp. 1625-1631 ◽  
Author(s):  
Hugues Oudart ◽  
Christiane Calgari ◽  
Margaret Andriamampandry ◽  
Yvon Le Maho ◽  
André Malan
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cancer Cachexia ◽  
Uncoupling Protein ◽  
Oxidative Capacity ◽  
Suppressive Effect ◽  
Tumor Bearing ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity ◽  
Stimulation Of

Despite anorexia, cancer development is frequently accompanied by an increase of energy expenditure. Considering the pivotal role played by brown adipose tissue (BAT) in the energy metabolism of small mammals, we investigated the functional and compositional modification in BAT of anorexic tumor-bearing (Yoshida sarcoma) and pair-fed control rats. BAT thermogenic activity (assessed by maximal mitochondrial GDP binding) was 1.8-fold greater in tumor-bearing rats than in controls, while the thermogenic capacity (assessed by measurement of uncoupling protein) was unchanged. This suggests that tumor bearing had induced an unmasking of uncoupling protein sites. BAT hypertrophy and hyperplasia, characteristic of full-fledged BAT activation, did not occur. The mitochondrial oxidative capacity of BAT (assessed by cytochrome c oxidase activity) was 1.6-fold lower in tumor-bearing than in control rats. The main compositional modification observed in BAT of tumor-bearing rats was an increase in the saturation of cardiolipin fatty acids. These results suggest that the BAT stimulation induced by tumor bearing after 10 days is almost exclusively functional and that the tissue development is limited, probably by anorexia. However, a suppressive effect of anorexia inhibition by tumor bearing cannot be excluded.Key words: cancer cachexia, nonshivering thermogenesis, brown adipose tissue cardiolipins.

scholarly journals Systemic  -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans

Diabetes ◽  
2012 ◽  
Vol 61 (12) ◽  
pp. 3106-3113 ◽  
Author(s):  
M. J. Vosselman ◽  
A. A. J. J. van der Lans ◽  
B. Brans ◽  
R. Wierts ◽  
M. A. van Baak ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Adrenergic Stimulation ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity ◽  
Stimulation Of

Responses of brown adipose tissue activity to unloading in rats

1995 ◽  
Vol 78 (2) ◽  
pp. 384-387 ◽  
Author(s):  
H. Yamashita ◽  
Y. Ohira ◽  
T. Wakatsuki ◽  
M. Yamamoto ◽  
T. Kizaki ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Mitochondrial Fraction ◽  
Hindlimb Suspension ◽  
Chemical Components ◽  
Brown Adipose ◽  
Male Wistar Rats ◽  
Brown Adipose Tissue Activity ◽  
Thermogenic Capacity

To study the responses of thermogenic activity in brown adipose tissue (BAT) to unloading, male Wistar rats were hindlimb suspended for 10 days. Compared with control rats, a significant increase in the BAT-to-body mass ratio and considerable differences in chemical components in BAT were observed in the hindlimb-suspended rats. These findings indicate a marked increase in the thermogenic capacity in BAT of the experimental group. Likewise, the thermogenic activity (which was assessed by guanosine 5′-diphosphate binding to BAT mitochondria) was markedly greater in the mitochondria recovered from BAT of the hindlimb-suspended rats than in those from the control rats (1,610 +/- 450 vs. 202 +/- 132 pmol recovered). Moreover, the uncoupling protein content in the BAT mitochondrial fraction of the hindlimb-suspended rats was significantly higher (1.6-fold) than that in the control rats. As was expected, the uncoupling protein mRNA expression was greater in hindlimb-suspended rats than in control animals. These results suggest that chronic hindlimb suspension leads to an increase in both the thermogenic capacity and the activity in BAT of rats.

Short Dietary Intervention with Olive Oil Increases Brown Adipose Tissue Activity in Lean But Not Overweight/Obese Subjects

2020 ◽  
Author(s):  
Milena Monfort-Pires ◽  
Muuez U-Din ◽  
Guilherme A. Nogueira ◽  
Juliana de Almeida-Faria ◽  
Davi Sidarta-Oliveira ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Olive Oil ◽  
Dietary Intervention ◽  
Brown Adipose ◽  
Obese Subjects ◽  
Brown Adipose Tissue Activity

scholarly journals A single mutation in uncoupling protein of rat brown adipose tissue mitochondria abolishes GDP sensitivity of H+ transport.

1994 ◽  
Vol 269 (10) ◽  
pp. 7435-7438
Author(s):  
D.L. Murdza-Inglis ◽  
M. Modriansky ◽  
H.V. Patel ◽  
G. Woldegiorgis ◽  
K.B. Freeman ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Protein ◽  
Single Mutation ◽  
Brown Adipose

Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype

Metabolism ◽  
2021 ◽  
Vol 117 ◽  
pp. 154709 ◽  
Author(s):  
Tim Hollstein ◽  
Karyne Vinales ◽  
Kong Y. Chen ◽  
Aaron M. Cypess ◽  
Alessio Basolo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Thrifty Phenotype ◽  
Brown Adipose ◽  
Metabolic Feature ◽  
Brown Adipose Tissue Activity

scholarly journals TAF7L modulates brown adipose tissue formation

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Haiying Zhou ◽  
Bo Wan ◽  
Ivan Grubisic ◽  
Tommy Kaplan ◽  
Robert Tjian
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Core Promoter ◽  
Uncoupling Protein ◽  
Dna Looping ◽  
Chromatin Interactions ◽  
Brown Adipose ◽  
Important Regulator

Brown adipose tissue (BAT) plays an essential role in metabolic homeostasis by dissipating energy via thermogenesis through uncoupling protein 1 (UCP1). Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation. In this study, we show that TAF7L also serves as a molecular switch between brown fat and muscle lineages in vivo and in vitro. In adipose tissue, TAF7L-containing TFIID complexes associate with PPARγ to mediate DNA looping between distal enhancers and core promoter elements. Our findings suggest that the presence of the tissue-specific TAF7L subunit in TFIID functions to promote long-range chromatin interactions during BAT lineage specification.

scholarly journals Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice

Pain ◽  
2016 ◽  
Vol 157 (11) ◽  
pp. 2561-2570 ◽  
Author(s):  
Elizabeth M. Goudie-DeAngelis ◽  
Ramy E. Abdelhamid ◽  
Myra G. Nunez ◽  
Casey L. Kissel ◽  
Katalin J. Kovács ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity
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