Sensitivity changes to inotropic agents in rabbit atria after chronic experimental diabetes

1988 ◽  
Vol 66 (12) ◽  
pp. 1475-1480 ◽  
Author(s):  
Paul F. Grassby ◽  
John H. McNeill
Keyword(s):  
Thyroid Hormone ◽  
Experimental Diabetes ◽  
Diabetic Rat ◽  
Inotropic Agents ◽  
Adrenergic Stimulation ◽  
Response Curves ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Serum Thyroid Hormones ◽  
Low Serum

The effect of experimental diabetes on the sensitivity of isolated left atrial strips to inotropic agents was investigated in rabbits made diabetic with alloxan. After 4 weeks of diabetes no change in sensitivity was detected in response to isoproterenol or ouabain. In contrast, 15 weeks of diabetes induced a decreased sensitivity to β-adrenergic stimulation, exhibited as a shift to the right in concentration–response curves obtained in response to isoproterenol and noradrenaline. In addition, after 15 weeks of diabetes the inotropic response to ouabain was depressed, and a small decrease in sensitivity was detected in response to forskolin. In contrast, no significant changes in the concentration–response curves obtained from α-adrenergic stimulation by phenylephrine or calcium chloride were detected. Unlike the streptozotocin diabetic rat, which exhibits low serum thyroid hormone levels, no changes in serum thyroid hormones were detected in the alloxan diabetic rabbit. It is suggested that the increased inotropic sensitivity to α-adrenergic agonists observed in the diabetic rat, but not in the rabbit, may be due to low serum thyroid hormone levels. In contrast, the deleterious effects of diabetes on β-adrenergic and ouabain sensitivity occur independently of changes in serum thyroid hormones.

scholarly journals Relative contribution of cysteine and methionine to glutathione content and thyroid hormone levels in the rat

1987 ◽  
Vol 58 (1) ◽  
pp. 105-111 ◽  
Author(s):  
C. Suberville ◽  
P. Higueret ◽  
D. Taruoura ◽  
H. Garcin ◽  
D. Higueret
Keyword(s):  
Thyroid Hormone ◽  
Pisum Sativum ◽  
Thyroid Hormones ◽  
Reduced Glutathione ◽  
Pea Protein ◽  
Relative Contribution ◽  
Methionine Supplementation ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Serum Thyroid Hormones

1. For a period of 24 d rats were given diets containing either casein or pea (Pisum sativum) protein at two different concentrations (180 and 120 g/kg) without or with cysteine or cysteine + methionine supplementation.2. The effects of these diets on levels of blood and liver reduced glutathione (GSH) and serum thyroid hormones were studied.3. When compared with the 180 g casein/kg diet, the 120 g casein/kg diet decreased liver GSH and serum thyroid hormone concentrations. These changes were related to dietary cysteine supply since supplementation induced an increase in these variables.4. When compared with 180 g pea protein/kg diet, the 120 g pea protein/kg diet decreased liver GSH and serum thyroid hormone concentrations. These changes could not be corrected by cysteine or cysteine + methionine supplementation.

scholarly journals Effects of Daily Kelp (Laminaria japonica) Intake on Body Composition, Serum Lipid Levels, and Thyroid Hormone Levels in Healthy Japanese Adults: A Randomized, Double-Blind Study

Marine Drugs ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 352
Author(s):  
Seiichiro Aoe ◽  
Chiemi Yamanaka ◽  
Hirofumi Ohtoshi ◽  
Fumiko Nakamura ◽  
Suguru Fujiwara
Keyword(s):  
Thyroid Hormone ◽  
Body Fat ◽  
Laminaria Japonica ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Double Blind ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
Male Subjects ◽  
Japanese Subjects

To investigate whether supplementation with iodine-reduced kelp (Laminaria japonica) powder decreases body fat composition in overweight Japanese subjects, a randomized, double-blind, placebo-controlled intervention study was conducted in 50 Japanese subjects with body mass index (BMI) ≥25 and <30 kg/m2. Subjects were randomly assigned to consume thirty tablets/d (10 tablets orally, 3 times/d) containing either iodine-reduced kelp powder (test, 6 g kelp powder corresponding to 3 g alginate/d) or kelp-free powder (placebo) for 8 weeks. Anthropometric measurements, blood lipids, and serum thyroid hormone levels were obtained before and after the trial. Body fat percentage was significantly decreased in male subjects from the test group compared with the placebo group. The same tendency was observed for body weight (p = 0.065) and BMI (p = 0.072) in male subjects. No significant changes in anthropometric measurements or visceral fat area were observed in female subjects. Serum thyroid hormone concentrations did not increase after 1.03 mg/d of iodine supplementation through kelp intake. The intake of iodine-reduced kelp powder led to significant and safe reductions in body fat percentage in overweight male subjects. The consumption of kelp high in alginate may contribute to preventing obesity without influencing thyroid function in Japanese subjects with a relatively high intake of iodine from seaweed.

Seasonal changes in serum thyroid hormone levels in ruffed grouse maintained under natural conditions of temperature and photoperiod

1979 ◽  
Vol 57 (10) ◽  
pp. 2022-2027 ◽  
Author(s):  
A. Garbutt ◽  
J. F. Leatherland ◽  
A. L. A. Middleton
Keyword(s):  
Thyroid Hormone ◽  
Seasonal Changes ◽  
Gonadal Development ◽  
Early Spring ◽  
Light Period ◽  
Ruffed Grouse ◽  
Natural Conditions ◽  
Blood Samples ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels

Serum triiodothyronine (T3) and thyroxine (T4) concentrations were measured in a population of ruffed grouse, held outdoors under natural conditions of photoperiod and temperature. Blood samples were collected at monthly intervals, and at the solstices and equinoxes to test for variation through the light period. No changes in T4 or T3 levels were found during the light period but levels of T3 and T4 showed marked seasonal changes. Lowest T4 and T3 levels were found in birds during the winter months, with an increase in the concentration of both hormones in early spring concomitant with gonadal development in the adults. A lowering of serum T4 and T3 values was associated with the period of molt.

scholarly journals Serum Thyroid Hormone Levels in Healthy Children from Birth to Adulthood and in Short Children Born Small for Gestational Age

2012 ◽  
Vol 97 (9) ◽  
pp. 3170-3178 ◽  
Author(s):  
Annemieke J. Lem ◽  
Yolanda B. de Rijke ◽  
Hans van Toor ◽  
Maria A. J. de Ridder ◽  
Theo J. Visser ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Healthy Children ◽  
Hormone Levels ◽  
Short Children ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels
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