The interaction of histamine with other bronchoconstrictor mediators

1987 ◽  
Vol 65 (3) ◽  
pp. 442-447 ◽  
Author(s):  
J. F. Burka
Keyword(s):  
Arachidonic Acid ◽  
Receptor Antagonist ◽  
Therapeutic Efficacy ◽  
Platelet Activating Factor ◽  
Airway Hyperreactivity ◽  
Specific Receptor ◽  
Arachidonic Acid Metabolites ◽  
Other Substances ◽  
Acid Metabolites ◽  
Antihistaminic Drugs

The lack of therapeutic efficacy of antihistaminic drugs in the treatment of asthma has led to the search and discovery of other bronchoconstrictor agents, particularly leukotrienes, thromboxanes, and platelet-activating factor. However, specific receptor antagonist for any of these substances have also not been particularly effective in inhibiting allergic bronchoconstriction. It is now generally accepted that histamine, arachidonic acid metabolites, platelet-activating factor, and possibly other substances are all involved to varying degrees in asthma and may indeed interact. This paper reviews the interaction of these mediators and how they contribute to airway hyperreactivity.

Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation

1996 ◽  
Vol 134 (6) ◽  
pp. 1060-1064 ◽  
Author(s):  
S. IZAKI ◽  
T. YAMAMOTO ◽  
Y. GOTO ◽  
S. ISHIMARU ◽  
F. YUDATE ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Platelet Activating Factor ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites

Effect of Lipoxygenase Inhibition on Mucous Glycoprotein Secretion from Chinchilla Middle Ear Fpithelial Cells in Vitro

1996 ◽  
Vol 105 (11) ◽  
pp. 916-921 ◽  
Author(s):  
Jizhen Lin ◽  
Youngki Kim ◽  
Frank Ondrey ◽  
Chris Lees ◽  
Steven K. Juhn
Keyword(s):  
Arachidonic Acid ◽  
Epithelial Cells ◽  
Middle Ear ◽  
Platelet Activating Factor ◽  
Lipoxygenase Inhibitor ◽  
Lipoxygenase Inhibition ◽  
Arachidonic Acid Metabolites ◽  
Acid Metabolites ◽  
Glycoprotein Secretion

Lipoxygenase is an enzyme that metabolizes arachidonic acid down to leukotrienes. Recent studies have shown that the enzyme is implicated in mucous glycoprotein (MGP) secretion stimulated by inflammatory mediators in the airways, suggesting its possible role in secretion of MGP from middle ear epithelial cells. To investigate a correlation between MGP secretion and the arachidonic acid metabolites, we examined the effects of nordihydroguaretic acid (NDGA, both a cyclooxygenase and lipoxygenase inhibitor), low-dose indomethacin (an inhibitor of cyclooxygenase), and A63162 (an inhibitor of lipoxygenase) on MGP secretion in cultured chinchilla middle ear epithelial cells. It was found that lipoxygenase inhibition led to reduction of MGP secretion from cultured chinchilla middle ear epithelial cells, while cyclooxygenase inhibition did not. Both cyclooxygenase and lipoxygenase inhibition resulted in profound blockage of MGP secretion in baseline and platelet activating factor-stimulated MGP secretion. It was concluded, therefore, that MGP secretion was linked to arachidonic acid metabolites, especially lipoxygenase products.

scholarly journals Effects of arachidonic acid metabolites and platelet-activating factor(PAF) on interleukin-1 synthesis from mouse hepatic sinusoidal endothelium.

Kanzo ◽  
1990 ◽  
Vol 31 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Yasuhiro MIZOGUCHI ◽  
Yuzo ICHIKAWA ◽  
Norifumi KAWADA ◽  
Kenzo KOBAYASHI ◽  
Seiji MORISAWA ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Interleukin 1 ◽  
Platelet Activating Factor ◽  
Arachidonic Acid Metabolites ◽  
Sinusoidal Endothelium ◽  
Acid Metabolites
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