Effects of thyroid and growth hormone deficiency, and food restriction on heart mass, with and without added stress (carboxyhemoglobinemia)

1985 ◽  
Vol 63 (6) ◽  
pp. 642-648 ◽  
Author(s):  
David G. Penney ◽  
Bernd G. Barthel
Keyword(s):  
Growth Hormone ◽  
Food Restriction ◽  
Male Rats ◽  
Hormone Deficiency ◽  
Cardiac Growth ◽  
Hormone Levels ◽  
Cardiac Atrophy ◽  
Body Weights ◽  
Heart Mass ◽  
The Right

The roles of thyroid and growth hormone, and food restriction in maintenance of heart mass and in carbon monoxide-stimulated cardiac growth were examined. First, thyroidectomized and normal adult male rats inhaled up to 500 ppm CO in air for 42 days. Combined ventricular weights of thyroidectomized rats inhaling CO and air were 12 and 23% smaller than predicted, respectively, while the combined ventricular weight of normal rats inhaling CO was 29% larger than predicted. Thyroidectomy increased the mass of the left ventricle relative to the right ventricle; this was reversed by CO treatment. While the hematocrit increased in thyroidectomized–CO rats, it was lower than in normal–CO rats: likewise the hematocrit of thyroidectomized–AIR rats was lower than that of normal rats in air. Body weights of the thyroidectomized rats were 57% that of normals. As additional controls, two groups of normal rats (one AIR, one CO) were maintained at the same body weight as the thyroidectomized rats, by adjusting food intake. Combined ventricular weight was less than predicted in AIR rats and failed to increase in CO animals, while hematocrits were the same as normals in air and in CO. Serum thyroxine (T4) and growth hormone levels assayed in thyroidectomized rats were less than 15 and 25% of normal rats, respectively. Growth hormone levels were not altered by CO inhalation in thyroidectomized and in normal rats. Levels of both hormones were normal in food-restricted rats. While thyroidectomy produced cardiac atrophy, cardiac growth was stimulated by CO inhalation, although heart mass then only approached that of normals in air. Food restriction also produced cardiac atrophy, but CO inhalation failed to stimulate heart growth.

Influence of in utero di-n-hexyl phthalate and di-cyclohexyl phthalate exposure on the endocrine glands and T3, T4, and TSH hormone levels of male and female rats: Postnatal outcomes

2020 ◽  
Vol 36 (6) ◽  
pp. 399-416
Author(s):  
Nurhayat Barlas ◽  
Emre Göktekin ◽  
Gözde Karabulut
Keyword(s):  
Pituitary Gland ◽  
Dose Group ◽  
Female Rats ◽  
Male Rats ◽  
High Dose ◽  
Hormone Levels ◽  
Male And Female Rats ◽  
Endocrine Organs ◽  
Body Weights ◽  
Juvenile Stages

The present study was designed to evaluate the effects of di- n-hexyl phthalate (DHP) and di-cyclohexyl phthalate (DCHP) on endocrine organs in rats. Oil control, 20-, 100-, and 500 mg/kg dose groups were selected and administered to pregnant rats on gestational days 6–19 by oral gavage. The neonatal stages of rats continued until postnatal day 20 and the- juvenile stages of rats continued until postnatal day of 32. The rats were allowed to mature until the neonatal and juvenile stages and there after, they were divided into four groups corresponding to the treatment levels. Body and organ weights were recorded, serum was collected, and thyroid, pancreas, pituitary gland, and adrenal gland were removed. There was a decrease in body weights in the 20- and 500mg/kg DHP and in the 20-mg/kg DCHP dose groups in neonatal male rats. In contrast, for female rats, there was an increase in body weights in the 100-mg/kg DCHP dose group and there was a decrease in body weights in the 500-mg/kg DHP dose group. Body weights were increased at 20 and 500 mg/kg in the DHP-exposed juvenile male rats. Serum thyroid-stimulating hormone (TSH) levels were increased in neonatal male rats, while they were increased in the 100-mg/kg DHP group of neonatal and juvenile female rats. Serum triiodothyronine (T3) levels were increased at the high dose of DHP for neonatal male rats and at the low and high dose levels of DCHP for female rats. Serum thyroxine (T4) levels were increased in neonatal rats for DHP. Also, some histopathological changes were observed in the thyroid, pancreas, adrenal, and pituitary gland. In conclusion, it was shown that DHP and DCHP caused negative effects on T3, T4, and TSH hormone levels.

Growth hormone levels in the diagnosis of growth hormone deficiency in adulthood

Pituitary ◽  
2007 ◽  
Vol 10 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Ginevra Corneli ◽  
Valentina Gasco ◽  
Flavia Prodam ◽  
Silvia Grottoli ◽  
Gianluca Aimaretti ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Hormone Levels

24-Hour Pattern of Circulating Prolactin and Growth Hormone Levels and Submaxillary Lymph Node Immune Responses in Growing Male Rats Subjected to Social Isolation

Endocrine ◽  
2004 ◽  
Vol 25 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Ana I. Esquifino ◽  
María P. Alvarez ◽  
Pilar Cano ◽  
Fernando Chacon ◽  
Carlos F. Reyes Toso ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Lymph Node ◽  
Immune Responses ◽  
Social Isolation ◽  
Male Rats ◽  
Hormone Levels

The Advantage of Measuring Stimulated as Compared with Spontaneous Growth Hormone Levels in the Diagnosis of Growth Hormone Deficiency

1988 ◽  
Vol 319 (4) ◽  
pp. 201-207 ◽  
Author(s):  
Susan Rogers Rose ◽  
Judith Levine Ross ◽  
Mercedes Uriarte ◽  
Kevin M. Barnes ◽  
Fernando G. Cassorla ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Spontaneous Growth ◽  
Hormone Levels

On Angiomas of Retina, Brain, and Skin

PEDIATRICS ◽  
1981 ◽  
Vol 67 (5) ◽  
pp. 753-754
Author(s):  
Louis I. Sobel ◽  
Jeffrey G. Odel ◽  
Alan H. Friedman
Keyword(s):  
Growth Hormone ◽  
Vascular Malformations ◽  
Hormone Deficiency ◽  
Upper Eyelid ◽  
Cerebral Angiogram ◽  
Suprasellar Region ◽  
Weber Syndrome ◽  
Sturge Weber Syndrome ◽  
Clinical Description ◽  
The Right

Recently Russell et al1 (Pediatrics 66: 306, 1980) described a child with a hemangioma of the right side of the forehead and right upper eyelid, an arteriovenous malformation of the basal ganglia and suprasellar region, and an ipsilateral angiomatous ocular lesion, who had an isolated growth hormone deficiency. They concluded that the vascular malformations were consistent with a variant of the Sturge-Weber syndrome. It is our opinion that their fundus and cerebral angiogram illustrations and the clinical description of the cutaneous vascular nevi represent a case of Wyburn-Mason syndnome.2-4

scholarly journals Growth hormone therapy in children with partial growth hormone deficiency. Are we treating the right patients?

2020 ◽  
Vol 26 (2) ◽  
pp. 65-72
Author(s):  
Barbara Krukowska-Andrzejczyk ◽  
Maria Kalina ◽  
Barbara Kalina-Faska ◽  
Ewa Małecka-Tendera
Keyword(s):  
Growth Hormone ◽  
Hormone Therapy ◽  
Growth Hormone Deficiency ◽  
Growth Hormone Therapy ◽  
Hormone Deficiency ◽  
The Right

scholarly journals Measuring IGF-1 and IGFBP-3 profiles in women seeking assisted reproduction; relationship to serum growth hormone levels (Study 3)

2020 ◽  
Vol 13 (3) ◽  
pp. 032-053
Author(s):  
John L Yovich ◽  
Syeda Zaidi ◽  
Minh DK Nguyen ◽  
Peter M Hinchliffe
Keyword(s):  
Growth Hormone ◽  
Screening Test ◽  
Assisted Reproductive Technologies ◽  
Human Growth ◽  
Reproductive Technologies ◽  
Hormone Deficiency ◽  
Serum Growth Hormone ◽  
Hormone Levels ◽  
Adult Growth ◽  
Igfbp 3

Extending from our first two studies examining the IGF profile (IGF-1, IGFBP-3 and the ratio of IGFBP-3/ IGF-1) in women presenting for assisted reproductive technologies (ART), this study examines its relevance to the testing of human growth hormone (hGH) levels on the same blood sample. These were taken in the morning during the early follicular phase of the woman’s menstrual cycle and included 408 women who were ART-naïve, undertaking the tests as part of an assessment cycle prior to any ART treatment. The growth hormone levels were also tested on a further 945 women classified as ART-interval cases. It was shown that the vast majority of hGH levels (73%) were very low at <1.0 ng/mL and 22% are extremely low <0.1 ng/mL, close to the detection level of the chemiluminescent immunoassay (0.03 ng/mL). Only 12% of hGH levels were recorded in the range ≥3.0 ng/mL, levels which exclude adult growth hormone deficiency (AGHD). Although IGF-1 levels are regarded as a screening test for AGHD, our studies showed no correlation between hGH levels and the entire range of IGF-1 levels, neither across IGFBP-3 levels, nor across IGF Ratios, albeit there was an apparent inverse trend for the latter. Across the entire age range, the hGH levels were not statistically different among neither the ART-naïve nor the ART-interval women. Furthermore, hGH levels were not different among the clinical parameters of stature or BMI; nor for ovarian reserve parameters AMH or AFC. It is concluded that serum hGH screening probably has very limited value as a screening test for potential AGHD.

GROWTH HORMONE LEVELS DURING SLEEP IN NORMAL AND GROWTH HORMONE DEFICIENT CHILDREN

PEDIATRICS ◽  
1971 ◽  
Vol 48 (6) ◽  
pp. 946-954
Author(s):  
Louis E. Underwood ◽  
Kazuo Azumi ◽  
Sandra J. Voina ◽  
Judson J. Van Wyk
Keyword(s):  
Growth Hormone ◽  
Wave Pattern ◽  
Hormone Deficiency ◽  
Deep Sleep ◽  
Plasma Growth Hormone ◽  
Normal Children ◽  
Hormone Levels ◽  
Serial Sampling ◽  
Hormone Responses ◽  
Blood Specimens

Plasma growth hormone levels were determined from samples drawn at 15-minute intervals during the first 2 hours of spontaneous, nocturnal sleep in 16 normal children, one nongrowth hormone deficient dwarf, and three children with hypopituitarism. Depth of sleep was assessed by continuous EEC monitoring. Daytime growth hormone responses to insulin-induced hypoglycemia were also assessed in most of these children and in a larger group of normal and hypopituitary children. In the normal children and in the nongrowth hormone deficient dwarf, increases in plasma growth hormone after the onset of the slow wave pattern on EEG were equivalent to those seen after insulin-induced hypoglycemia. No significant changes in growth hormone levels were seen in the hypopituitary patients. Interpretation of growth hormone levels in blood specimens obtained by serial sampling after the onset of deep sleep appears to be as reliable a method of assessing pituitary function as the levels resulting from insulin-induced hypoglycemia. Although growth hormone analysis of a single sample taken about 1 hour after the onset of deep sleep should exclude the diagnosis of growth hormone deficiency in as many as 70% of the nongrowth hormone deficient individuals, a positive diagnosis of hyposomatotropism must be based on either serial sampling during deep sleep or challenge with insulin and/or arginine.

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