Erratum: Positive feedback regulation of noradrenaline release from sympathetic nerves: a questionable hypothesis

1982 ◽  
Vol 60 (10) ◽  
pp. 1319-1319
Author(s):  
Stanley Kalsner
Keyword(s):  
Noradrenaline Release ◽  
Positive Feedback ◽  
Feedback Regulation ◽  
Sympathetic Nerves

Positive feedback regulation of noradrenaline release from sympathetic nerves: a questionable hypothesis

1982 ◽  
Vol 60 (5) ◽  
pp. 737-743 ◽  
Author(s):  
Stanley Kalsner
Keyword(s):  
Noradrenaline Release ◽  
Positive Feedback ◽  
Feedback Regulation ◽  
Feedback System ◽  
Sympathetic Nerves ◽  
Inhibitory Effect ◽  
Similar Extent ◽  
Test Conditions ◽  
Beta Receptors ◽  
Exogenous Agents

The effects of known agonists and of an antagonist on the stimulation-induced efflux of [3H]noradrenaline from left atria of guinea pigs was assessed. This was done to evaluate the hypothesis of presynaptic beta receptors mediating a positive feedback system. Isoproterenol (1.2 × 10−8 M) enhanced the efflux of tritium with 50 pulses at all four test frequencies and did so to a similar extent at three of them. Exogenous noradrenaline (1.8 × 10−6 M) inhibited efflux and isoproterenol was ineffective as an enhancer of efflux in its presence. Propranolol (1 × 10−7 M) did not reliably increase the inhibitory effect of added noradrenaline on stimulation-induced efflux nor did the antagonist by itself under a variety of test conditions decrease the stimulation-induced efflux of tritium. It is concluded that the synaptic quantities of transmitter do not determine the magnitudes of the effects of exogenous agents on tritium efflux and that positive feedback, for both theoretical and empirical considerations, does not function during neurosecretion

Evidence that transmitter release in sympathetic nerves is not set by feedback via presynaptic receptors

1983 ◽  
Vol 61 (10) ◽  
pp. 1197-1201 ◽  
Author(s):  
Stanley Kalsner
Keyword(s):  
Guinea Pig ◽  
Negative Feedback ◽  
Noradrenaline Release ◽  
Transmitter Release ◽  
Feedback Regulation ◽  
Feedback System ◽  
Sympathetic Nerves ◽  
Presynaptic Receptors ◽  
Negative Feedback Regulation

The possibility of negative feedback regulation of noradrenaline release was studied in the sympathetically innervated ureters of the guinea pig mounted in vitro. Tissues were transmurally stimulated with 300 pulses at 2 Hz over a range of voltages, from 10 to 60 V. It was determined that the output of transmitter increased with increasing voltage but that the effects of supposed presynaptic antagonism by yohimbine and presynaptic agonism by added noradrenaline did not fulfill the requirements of presynaptic theory governing negative feedback. It is concluded that the presynaptic effects of these drugs is neither linked to the operation of a negative feedback system nor sensitive to the perineuronal concentrations of free and active neurotransmitter.

Local Positive Feedback Regulation Determines Cell Shape in Root Hair Cells

Science ◽  
2008 ◽  
Vol 319 (5867) ◽  
pp. 1241-1244 ◽  
Author(s):  
S. Takeda ◽  
C. Gapper ◽  
H. Kaya ◽  
E. Bell ◽  
K. Kuchitsu ◽  
...  
Keyword(s):  
Hair Cells ◽  
Positive Feedback ◽  
Root Hair ◽  
Cell Shape ◽  
Feedback Regulation ◽  
Root Hair Cells

scholarly journals HSPA12A is required for adipocyte differentiation and diet-induced obesity through a positive feedback regulation with PPARγ

2019 ◽  
Vol 26 (11) ◽  
pp. 2253-2267 ◽  
Author(s):  
Xiaojin Zhang ◽  
Xuan Chen ◽  
Tao qi ◽  
Qiuyue Kong ◽  
Hao Cheng ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Adipocyte Differentiation ◽  
Feedback Regulation ◽  
Diet Induced Obesity

A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells

2014 ◽  
Vol 449 (3) ◽  
pp. 295-300 ◽  
Author(s):  
Qiao Zhang ◽  
Zhe Yang ◽  
Weiping Wang ◽  
Ting Guo ◽  
Zhuqing Jia ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Feedback Regulation ◽  
Β Cells ◽  
Pancreatic Β Cells
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