Toxin-induced activation of muscle hydrolases

Application of batrachotoxin, lysolecithin, tetrodotoxin, or veratridine to mouse skeletal muscle results in an increase in the activity of the following lysosomal enzymes: acid protease, acid phosphatase, and N-acetylglucosarninidase. Batrachotoxin caused the greatest increase in lysosomal enzymes while veratridine resulted in the smallest response. The increase in lysosomal enzymes was most marked within 1–2 days after toxin application and returned to normal values after 8–12 days.