Catecholamines and the cephalic phase of gastric secretion

1981 ◽  
Vol 59 (11) ◽  
pp. 1189-1191 ◽  
Author(s):  
K. Etzel ◽  
J. Wisecarver ◽  
D. F. Magee
Keyword(s):  
Gastric Secretion ◽  
Conscious Dogs ◽  
Pepsin Secretion ◽  
Heidenhain Pouch ◽  
Cephalic Phase ◽  
Adrenergic Agent

Methoxamine, an α-adrenergic agent, and isoproterenol, a β-adrenergic agent, significantly augmented indirect vagally stimulated (intravenous 2-deoxy-D-glucose) acid and pepsin secretion from the main stomachs of conscious dogs. Heidenhain pouch secretion in the same dogs was unaffected.

LATENCY OF THE GASTRIC SECRETORY RESPONSE TO SHAM FEEDING IN THE DOG

1967 ◽  
Vol 45 (4) ◽  
pp. 633-641 ◽  
Author(s):  
R. M. Preshaw
Keyword(s):  
Gastric Acid ◽  
Secretory Response ◽  
Conscious Dogs ◽  
Pepsin Secretion ◽  
Sham Feeding

In conscious dogs with gastric fistulas the latency of both the gastric acid and pepsin responses to sham feeding was about 6 min. When a background secretion was induced with various closes of hog gastrin, the latency of the acid response to sham feeding was unchanged, but the latency of the pepsin response was shortened. The peak rates of acid and pepsin secretion after sham feeding were not altered by the infusion of gastrin.

Effects of bombesin on food intake and gastric acid secretion in cats

1989 ◽  
Vol 256 (1) ◽  
pp. R181-R186
Author(s):  
A. Bado ◽  
M. J. Lewin ◽  
M. Dubrasquet
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Gastric Secretion ◽  
Acid Secretion ◽  
Gastric Fistula ◽  
Single Class ◽  
Heidenhain Pouch ◽  
Daily Food Intake ◽  
Feeding Experiments ◽  
Daily Food

The brain and gut peptide bombesin has been reported both to stimulate gastric secretion and to induce satiety. To understand how the peripheral administration of bombesin affects food intake and whether gastric mechanisms are involved, a comparative study of the doses of bombesin active on gastric secretion, gastric emptying, and food intake was undertaken in cats provided with a gastric fistula and a denervated Heidenhain pouch. The smallest dose of intravenous bombesin that stimulated significantly basal acid secretion (20 pmol.kg-1.h-1) by the gastric fistula also enhanced meal-stimulated acid secretion by the Heidenhain pouch (+138%, P less than 0.01), delayed gastric emptying of a liquid protein meal (-30%, P less than 0.01), and suppressed food intake when the test meal was allowed to reach the stomach (-15%, P less than 0.01). Conversely, in sham-feeding experiments, the same dose of bombesin increased food intake (+35%, P less than 0.01). In full-day experiments conducted in nonfasted cats, bombesin decreased both the food intake in the 4-h period after the infusion and the daily food intake, whereas octapeptide cholecystokinin induced a transient satiety but did not decrease daily food intake. These results indicate that in cats the interaction of bombesin with "pregastric" mechanisms is not sufficient to induce satiety and that a relation could exist between the effects of bombesin on gastric secretion, emptying, and food intake. A single class of receptors might be involved in these peripheral effects of bombesin.

Stimulating Effect of Vagotomy on Gastric Secretion in Heidenhain Pouch Dog

1953 ◽  
Vol 174 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Shirl O. Evans ◽  
Jose M. Zubiran ◽  
Jack D. McCarthy ◽  
Herzl Ragins ◽  
Edward R. Woodward ◽  
...  
Keyword(s):  
Gastric Secretion ◽  
Heidenhain Pouch

Effects of Calcium Infusion on Gastric Secretion in Heidenhain Pouch Dogs

1966 ◽  
Vol 1 (2) ◽  
pp. 124-131 ◽  
Author(s):  
M. Mignon ◽  
J.-M. Limbosch ◽  
J. H. Wyllie ◽  
M. J. Rheault ◽  
L. M. Nyhus
Keyword(s):  
Gastric Secretion ◽  
Heidenhain Pouch ◽  
Calcium Infusion

Alterations in gastric secretion following hypothalamic lesions producing hyperphagia

1965 ◽  
Vol 209 (2) ◽  
pp. 319-323 ◽  
Author(s):  
Peter T. Ridley ◽  
Frank P. Brooks
Keyword(s):  
Food Intake ◽  
Gastric Secretion ◽  
Neural Control ◽  
Neural Mechanisms ◽  
Gastric Fistula ◽  
Central Regulation ◽  
Pepsin Secretion ◽  
Insulin Hypoglycemia ◽  
Hypothalamic Lesions

Fasting gastric secretion and secretion during insulin hypoglycemia were collected from hypothalamic hyperphagic rats equipped with chronic gastric fistula in an attempt to correlate the hypothalamic neural mechanisms controlling food intake with gastric secretion. The interdigestive or basal fasting secretion of rats rendered hyperphagic by stereotaxic ablation of the ventromedial nuclei was significantly increased in volume, acid concentration and output, and pepsin output when compared with control and sham-operated rats and rats with hypothalamic lesions without hyperphagia. Hypothalamic hyperphagic rats did not show a significant increase in gastric secretion during insulin hypoglycemia, whereas the other groups did. The levels of hypoglycemia induced by insulin were comparable in all groups. These studies suggest an important role of the ventromedial nuclei in the central regulation of acid and pepsin secretion, and also relate the hypothalamic neural control of gastric secretion to that of food intake. The results also indicate that this nucleus is involved either as a "center" or pathway in the augmentation of gastric secretion by insulin hypoglycemia.

Inhibition of gastric secretion by thyroid preparations

1959 ◽  
Vol 196 (6) ◽  
pp. 1262-1265 ◽  
Author(s):  
E. S. Nasset ◽  
V. W. Logan ◽  
M. L. Kelley ◽  
Mary Thomas
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Gradual Decline ◽  
Heidenhain Pouch ◽  
Significant Fall ◽  
Lean Beef ◽  
Inhibition Of Gastric Secretion

Four dogs with Thomas gastric pouches and one dog with a Heidenhain pouch were stimulated to secrete gastric juice by feeding 100 gm of lean beef. Feeding whole desiccated thyroid ordinarily caused a significant fall in volume of gastric juice and in the total quantity of HCl secreted. Crystalline thyroxine yielded erratic results and one trial with triiodothyronine produced a significant increase in gastric secretion. Thyroidectomy in one dog resulted in a gradual decline in secretion, but hypothyroidism produced by administration of mercaptoimidazole in another animal lead to a significant increase in secretion.

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