Correlations between hemodynamic parameters of the liver and norepinephrine release upon hepatic nerve stimulation in the dog

1980 ◽  
Vol 58 (11) ◽  
pp. 1347-1355 ◽  
Author(s):  
N. Yamaguchi ◽  
D. Garceau
Keyword(s):  
Nerve Stimulation ◽  
Hemodynamic Parameters ◽  
Norepinephrine Release

Adrenergic and nonadrenergic cotransmitters inhibit insulin secretion during sympathetic stimulation in dogs

1992 ◽  
Vol 263 (1) ◽  
pp. E72-E78
Author(s):  
J. Lorrain ◽  
I. Angel ◽  
N. Duval ◽  
M. T. Eon ◽  
A. Oblin ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Insulin Release ◽  
Nerve Stimulation ◽  
Sympathetic Nerve ◽  
Perfusion Pressure ◽  
Blocking Agent ◽  
Norepinephrine Release ◽  
Sympathetic Nerve Stimulation ◽  
K Channels ◽  
Adrenoceptor Antagonist

Vascular and biochemical responses to pancreatic sympathetic nerve stimulation were investigated in the blood-perfused pancreas of anesthetized dogs. During sympathetic nerve stimulation, pancreatic perfusion pressure and norepinephrine release increased, whereas insulin secretion decreased. The latter effect did not occur after pretreatment with the alpha 2-adrenoceptor antagonist idazoxan. However, after beta-adrenoceptor blockade with propranolol, neither single administration of idazoxan nor the alpha 1-adrenoceptor antagonist prazosin or glibenclamide, a blocker of ATP-modulated K+ channels, affected the decrease in insulin secretion induced by sympathetic nerve stimulation. In contrast, the combination of glibenclamide with idazoxan markedly antagonised the decrease in insulin release evoked by the latter procedure. After depletion of catecholamines with syrosingopine, the stimulation-induced inhibition of insulin secretion remained unchanged even though no increases in pancreas perfusion pressure or norepinephrine release were observed. In this preparation, glibenclamide inhibited the decrease in insulin release by 50%. In animals pretreated with the neuronal blocking agent bretylium, all of the responses to sympathetic nerve stimulation were abolished. These results indicate that the inhibitory effects exerted by the sympathetic nervous system on insulin secretion are mediated not only by the classical neurotransmitter norepinephrine acting on alpha 2-adrenoceptors but also by a nonadrenergic cotransmitter that can maintain transmission under conditions of catecholamine deficiency. The postulated nonadrenergic cotransmitter(s) acts, at least partly, via the opening of ATP-modulated K+ channels blockable by glibenclamide, and its release can be prevented by the neuronal blocking agent bretylium.

scholarly journals Effect of angiotensin II on renal nerve stimulation-induced norepinephrine release in dogs

1987 ◽  
Vol 43 ◽  
pp. 96
Author(s):  
Toshiyuki Matsuoka ◽  
Yoshiharu Hayashi ◽  
Mizue Suzuki-Kusaba ◽  
Susumu Satoh
Keyword(s):  
Angiotensin Ii ◽  
Nerve Stimulation ◽  
Norepinephrine Release ◽  
Renal Nerve ◽  
Renal Nerve Stimulation

Interaction Between Norepinephrine Release and Intrarenal Angiotensin II Formation During Renal Nerve Stimulation in Dogs

2000 ◽  
Vol 35 (6) ◽  
pp. 831-837 ◽  
Author(s):  
Naoki Yamaguchi ◽  
Mizue Suzuki-Kusaba ◽  
Hiroaki Hisa ◽  
Yoshiharu Hayashi ◽  
Makoto Yoshida ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Nerve Stimulation ◽  
Norepinephrine Release ◽  
Renal Nerve ◽  
Renal Nerve Stimulation

Efficacy of transcutaneous electrical nerve stimulation (Active TENS versus Sham TENS) on hemodynamic stability and renal tissue perfusion guided by NGAL test for patients with hypovolemic shock - A prospective randomized clinical study

2021 ◽  
Author(s):  
Asmaa Aly Mahgoub ◽  
Ghada shalby mahran ◽  
Mostafa Samy Abas ◽  
Ahmed Mohamed Aly Obied allah ◽  
Alaa Soliman Abd-Elkader ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Nerve Stimulation ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Hypovolemic Shock ◽  
Tissue Perfusion ◽  
Renal Tissue ◽  
Hemodynamic Parameters ◽  
Hemodynamic Stability ◽  
Electrical Nerve Stimulation ◽  
Significant Difference

Abstract Background: Hypovolemic shock occurs due to many causes and it has complex patho-physiology which finally leads to decreased all organs perfusion. Transcutaneous electrical nerve stimulation (TENS) consists of a generic application of low-frequency, pulsed electrical currents transmitted by electrodes through the skin surface to stimulate the primary afferent pathways (peripheral nerves) to produce various physiological effects.Objective: Was to evaluate the effect of transcutaneous electrical nerve stimulation application on the renal tissue perfusion and hemodynamic stability for patients with hypovolemic shock.Design: A prospective, single-blind, randomized, sham-controlled trial. Patients were randomized into two groups (active TENS versus sham TENS). Active TENS group received resuscitation protocol and transcutaneous electrical nerve stimulation while sham TENS group received resuscitation protocol only.Setting: Data was collected from general and obstetric ICU.Main Outcome Measures: Improvement of renal tissue perfusion was considered the primary outcome and secondary outcomes was improvement of hemodynamic parameters.Results: TENS application had caused a highly statistical significant change in serum Creatinine and NGAL test (74.43 ± 7.16 in active TENS versus 114.48 ± 13.6 2 in sham TENS) and (7.35 ± 0.7716 in active TENS versus 20.76 ± 2.11 in sham TENS) (P = 0.007 & P= 0.000) respectively. There was highly statistical significant difference before treatment and after treatment regarding urea, creatinine and NGAL test in the control group (P= 0.002 & P= 0.006& P= 0.000) respectively and there was highly statistical significant difference before treatment and after treatment in TENS group regarding to serum Creatinine (P= 0.003).Conclusion: We concluded the following; Application of TENS is extremely effective on improvement of renal tissue perfusion and and hemodynamic parameters. Also TENS should be used as a nursing intervention to maintain hemodynamic stability in patients with hypovolemic shock in the intensive care unit and we found patients with hypovolemic shock who received active TENS had better outcomes than patients who received sham TENS.

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