La S-adénosyl-L-homocystéine : 1. Inductrice de sommeil

1980 ◽  
Vol 58 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Pierre Fonlupt ◽  
Maurice Roche ◽  
Lucien Cronenberger ◽  
Henri Pacheco

S-Adenosylhomocysteine, 0.1–20 mg/kg, influences the sleep patterns of rat, cat and rabbit by increasing the slow-wave and fast-wave sleep for 6 h. The SAH effects are increased by p-chlorophenylalanine and iproniazid and unchanged by reserpine. SAH effects are correlated with modification of norepinephrine and serotonin metabolism.

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A60-A60
Author(s):  
Ariel Neikrug ◽  
Shlomit Radom-Aizik ◽  
Ivy Chen ◽  
Annamarie Stehli ◽  
Kitty Lui ◽  
...  

Abstract Introduction Aerobic fitness facilitates brain synaptic plasticity, which influences global and local sleep expression. While it is known that sleep patterns/behavior and non-rapid eye movement (NREM) sleep slow wave activity (SWA) tracks brain maturation, little is known about how aerobic fitness and sleep interact during development in youth. The aim of this pilot was to characterize relationships among aerobic fitness, measures of global/local sleep expression, and habitual sleep patterns in children and adolescents. We hypothesized that greater aerobic fitness would be associated with better sleep quality, indicated by increased SWA. Methods 20 adolescents (mean age=14.6±2.3 years old, range 11-17, 11 females) were evaluated for AF (peak VO2 assessed by ramp-type progressive cycle ergometry in the laboratory), habitual sleep duration and efficiency (continuous 7-14 day actigraphy with sleep diary), and topographic patterns of spectral power in slow wave, theta, and sleep spindle frequency ranges in non-rapid eye movement (NREM) sleep using overnight polysomnography with high-density electroencephalography (hdEEG, 128 channels). Results Significant relationships were observed between peak VO2 and habitual bedtime (r=-0.604, p=0.013) and wake-up time (r=-0.644, p=0.007), with greater fitness associated with an earlier sleep schedule (going to bed and waking up earlier). Peak VO2 was a significant predictor of slow oscillations (0.5-1Hz, p=0.018) and theta activity (4.5-7.5Hz, p=0.002) over anterior frontal and central derivations (p<0.001 and p=0.001, respectively) after adjusting for sex and pubertal development stage. Similar associations were detected for fast sleep spindle activity (13-16Hz, p=0.006), which was greater over temporo-parietal derivations. Conclusion Greater AF was associated with earlier habitual sleep times and with enhanced expression of developmentally-relevant sleep oscillations during NREM sleep. These data suggest that AF may 1) minimize the behavioral sleep delay commonly seen during adolescence, and 2) impact topographically-specific features of sleep physiology known to mechanistically support neuroplasticity and cognitive processes which are dependent on prefrontal cortex and hippocampal function in adolescents and adults. Support (if any) NCATS grant #UL1TR001414 & PERC Systems Biology Fund


1997 ◽  
Vol 25 (5) ◽  
pp. 1150-1154 ◽  
Author(s):  
W. Lawson ◽  
A. Fernandez ◽  
T. Hutchings ◽  
G.P. Saraph

2020 ◽  
Author(s):  
L. Ai ◽  
L. N. Liu ◽  
C. M. Qin ◽  
X. J. Zhang ◽  
Y. P. Zhao

1966 ◽  
Vol 23 (3_suppl) ◽  
pp. 1203-1207 ◽  
Author(s):  
Frederick Baekeland ◽  
Richard Lasky

Visual stage-of-sleep analysis of the sleep EEGs of 10 college athletes under three different conditions of exercise suggests a general positive relationship between exercise and the amount of slow-wave (delta) sleep in a night's sleep as well as a stress effect of exercise obtained in the evening.


1992 ◽  
Vol 263 (6) ◽  
pp. R1339-R1346
Author(s):  
L. A. Toth ◽  
T. W. Gardiner ◽  
J. M. Krueger

Infectious disease is known to alter both sleep patterns and hydrocortisone (cortisol) concentrations in rabbits. Moreover, the sleep-altering effects of microbial infections are likely to be mediated via endogenous immune modulators whose actions are attenuated by glucocorticoids. To evaluate the relationships between sleep and glucocorticoids during infectious disease, the effects of cortisone administration (20 mg/kg, im) on sleep were examined before and after inoculation of rabbits with Staphylococcus aureus or Escherichia coli. When administered alone, cortisone did not alter the amount of time spent in slow-wave sleep (SWS) but did reduce electroencephalographic (EEG) slow-wave amplitudes during SWS, the number of bouts of SWS and the amount of time spent in rapid-eye-movement sleep. The duration of individual bouts of SWS was increased after cortisone treatment. Bacterially infected rabbits developed biphasic changes in sleep patterns that were characterized by an initial increase and a subsequent decrease both in SWS time and in EEG slow-wave amplitudes during sleep. Cortisone treatment attenuated these effects in S. aureus-inoculated rabbits. In contrast, cortisone treatment did not alter the initial phase of enhanced sleep in E. coli-inoculated rabbits but did attenuate the subsequent sleep suppression. These data indicate that glucocorticoid administration is associated with an attenuated sleep response in bacterially inoculated rabbits.


1970 ◽  
Vol 37 (4) ◽  
pp. 1107-1112 ◽  
Author(s):  
J. Lipkin ◽  
R. J. Clifton

Experiments are reported in which annealed aluminum tubes are subjected to a static plastic torque followed by a longitudinal compressive impact. Measurements are made of both longitudinal and shear strain-time profiles at stations along the specimen. Qualitatively, the strain response at the gages corresponds to the arrival of a fast wave for which torsional strain decreases while longitudinal strain increases followed by a slow wave for which both torsional and longitudinal strains increase. Between the slow and fast waves and following the slow wave, a strain rate of the order of 10 sec−1 is maintained.


2017 ◽  
Vol 118 ◽  
pp. 221-237 ◽  
Author(s):  
Behnam Soleimani ◽  
Oswald Knoth ◽  
Rüdiger Weiner
Keyword(s):  

1990 ◽  
Vol 64 (11) ◽  
pp. 1258-1261 ◽  
Author(s):  
D. P. Sheehan ◽  
R. McWilliams ◽  
N. S. Wolf ◽  
D. Edrich

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