Theophylline antagonizes flurazepam-induced depression of cerebral cortical neurons

1979 ◽  
Vol 57 (8) ◽  
pp. 917-920 ◽  
Author(s):  
J. W. Phillis ◽  
J. P. Edstrom ◽  
S. W. Ellis ◽  
J. R. Kirkpatrick
Keyword(s):  
Brain Tissue ◽  
Binding Sites ◽  
Cortical Neurons ◽  
Purinergic Receptor ◽  
Central Neurons ◽  
Cerebral Cortical Neurons

Intravenously administered theophylline (50–100 mg/kg) antagonized the depressant actions of adenosine and flurazepam on rat cerebral cortical neurons. When assessed in conjunction with recent reports that theophylline competes with diazepam for binding sites in brain tissue, this finding suggests that one action of the benzodiazepines may be exerted at a purinergic receptor associated with central neurons.

scholarly journals Effects of Shaoyao-Gancao Decoction on Infarcted Cerebral Cortical Neurons: Suppression of the Inflammatory Response following Cerebral Ischemia-Reperfusion in a Rat Model

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Ying Zhang ◽  
Xinling Jia ◽  
Jian Yang ◽  
Qing Li ◽  
Guofeng Yan ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Brain Tissue ◽  
Cortical Neurons ◽  
Ischemia Reperfusion ◽  
Serum Levels ◽  
Artery Occlusion ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Cortical Neurons ◽  
Staining Methods ◽  
Cerebral Artery Occlusion

The mechanisms by which Shaoyao-Gancao decoction (SGD) inhibits the production of inflammatory cytokines in serum and brain tissue after cerebral ischemia-reperfusion (CI-RP) in rats were investigated. A right middle cerebral artery occlusion was used to induce CI-RP after which the rats were divided into model (n=39), SGD (n=28), clopidogrel (n=25) and sham operated (n=34) groups. The Bederson scale was used to evaluate changes in behavioral indices. The levels of IL-1β, TNF-α, MCP-1, IL-10, RANTES, VEGF, and TGF-β1 in the serum and infarcted brain tissues were measured. Nissl body and immunohistochemical staining methods were used to detect biochemical changes in neurons, microglial cells, and astrocytes. Serum levels of VEGF, TNF-α, MCP-1, IL-1β, and IL-10 increased significantly 24 h after CI-RP. In brain tissue, levels of TNF-αand IL-1βsignificantly increased 24 h after CI-RP, whereas levels of TGF-β1 and MCP-1 were significantly higher 96 h after CI-RP (P<0.05). SGD or clopidogrel after CI-RP reduced TNF-αand IL-1βlevels in brain tissue and serum levels of MCP-1, IL-1β, and IL-10. SGD increased the number of NeuN-positive cells in infarcted brain tissue and reduced the number of IBA1-positive and GFAP-positive cells. The efficacy of SGD was significantly higher than that of clopidogrel.

Diazepam potentiation of purinergie depression of central neurons

1979 ◽  
Vol 57 (4) ◽  
pp. 432-435 ◽  
Author(s):  
J. W. Phillis
Keyword(s):  
Cortical Neurons ◽  
Spontaneous Firing ◽  
Central Neurons ◽  
Depressant Action ◽  
Cerebral Cortical Neurons ◽  
Brain Tissues

Intravenously or iontophoretically applied diazepam potentiated the depressant action of iontophoretically applied 5′-AMP on the spontaneous firing of rat cerebral cortical neurons. This potentiation of purinergic depression may be a result of the previously reported inhibition by diazepam of uptake of adenosine into brain tissues.

Neuroprotective effects of vitexin by inhibition of NMDA receptors in primary cultures of mouse cerebral cortical neurons

2013 ◽  
Vol 386 (1-2) ◽  
pp. 251-258 ◽  
Author(s):  
Le Yang ◽  
Zhi-ming Yang ◽  
Nan Zhang ◽  
Zhen Tian ◽  
Shui-bing Liu ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Cortical Neurons ◽  
Primary Cultures ◽  
Neuroprotective Effects ◽  
Cerebral Cortical Neurons

Demonstration of α1A-and α1B-adrenoceptor binding sites in human brain tissue

1989 ◽  
Vol 169 (2-3) ◽  
pp. 325-328 ◽  
Author(s):  
Gerhard Gross ◽  
Gertraud Hanft ◽  
Hubertus M. Mehdorn
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Binding Sites ◽  
Human Brain Tissue

scholarly journals Protective effects of the p38 MAPK inhibitor SB203580 on NMDA-induced injury in primary cerebral cortical neurons

2014 ◽  
Vol 10 (4) ◽  
pp. 1942-1948 ◽  
Author(s):  
XUE-WEN LIU ◽  
EN-FEI JI ◽  
PENG HE ◽  
RUI-XIAN XING ◽  
BU-XIAN TIAN ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Cortical Neurons ◽  
Protective Effects ◽  
Cerebral Cortical Neurons ◽  
P38 Mapk Inhibitor ◽  
Mapk Inhibitor

scholarly journals Astrocyte mediated protection of fetal cerebral cortical neurons from rotenone and paraquat

2012 ◽  
Vol 33 (2) ◽  
pp. 353-360 ◽  
Author(s):  
Mary Latha Rathinam ◽  
Lora Talley Watts ◽  
Madhusudhanan Narasimhan ◽  
Amanjot Kaur Riar ◽  
Lenin Mahimainathan ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Cerebral Cortical Neurons

Block of synapse formation between cerebral cortical neurons by a protein kinase inhibitor

1992 ◽  
Vol 135 (2) ◽  
pp. 255-258 ◽  
Author(s):  
Yoichiro Kuroda ◽  
Masumi Ichikawa ◽  
Kazuyo Muramoto ◽  
Kazuo Kobayashi ◽  
Yuzuru Matsuda ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cortical Neurons ◽  
Synapse Formation ◽  
Kinase Inhibitor ◽  
Protein Kinase Inhibitor ◽  
Cerebral Cortical Neurons
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