Bile flow and electrolyte composition of bile associated with maximum bilirubin excretion in sheep

1979 ◽  
Vol 57 (7) ◽  
pp. 710-716 ◽  
Author(s):  
James L. Barnhart ◽  
Dan W. Upson
Keyword(s):  
Steady State ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Biliary Excretion ◽  
Bile Flow ◽  
Bile Salts ◽  
Mixed Micelles ◽  
Electrolyte Composition ◽  
Bilirubin Excretion ◽  
The Common

Changes in the composition of bile accompanying the maximum biliary excretion (Emax) of bilirubin were investigated in sheep. Sheep fitted with chronic 'T-tubes' in the common bile duct were infused with taurocholate and bilirubin at various rates. Bile collected during both pre- and post-bilirubin steady-state periods was analyzed for the biliary concentration of electrolytes, bile salts, and bilirubin. Bilirubin Emax was 24.6 μmol/min while bile salt excretion during this period was 103 μmol/min. At Emax bilirubin entry into bile reached a concentration of 16.1 μmol/mL, increased the biliary concentration of sodium, did not change osmolarity of bile, and did not increase bile flow. The data suggest that bilirubin either interacts with mixed micelles in bile or forms molecular aggregates.

Effect of insulin on canalicular bile formation

1976 ◽  
Vol 231 (1) ◽  
pp. 40-43 ◽  
Author(s):  
RS Jones
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Intravenous Infusion ◽  
Bile Flow ◽  
Sodium Taurocholate ◽  
Duodenal Fistula ◽  
Bile Formation ◽  
Biliary Clearance ◽  
The Common ◽  
Bicarbonate Output

Mongrel dogs were prepared by cholecystectomy, ligation of the lesser pancreatic duct, and insertion of gastric and duodenal cannulas. The common bile duct was cannulated through the duodenal fistula. After bile flow had been stabilized by intravenous infusion of sodium taurocholate the dogs were given an intravenous injection of insulin or 0.9% NaCl (control). Insulin caused marked increases in bile flow, chloride output, and biliary clearance of erythritol and small increases in bicarbonate output and bile salt output. The increased erythritol clearance indicates that canalicular secretion contributes to insulin choleresis in dogs.

scholarly journals Expression of protein c-fos in cerebellum neurons of rats at cholestasis

2019 ◽  
Vol 16 (2) ◽  
pp. 135-141
Author(s):  
S. V. Emelyanchik ◽  
O. A. Karniushko ◽  
S. M. Zimatkin
Keyword(s):  
Nervous System ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Bile Flow ◽  
Protein C ◽  
White Male ◽  
Male Rats ◽  
Experimental Animals ◽  
The Common

Cholestasis (disturbance of the liver bile outflow into the duodenum) is a frequent complication of cholelithiasis and other pathologies of the hepatobiliary system. In this case, all metabolism types are disturbances and all body organs and systems, including the nervous system, are affected. The objective of the study was to establish changes in the c-fos immunoreactivity in the cerebellum neurons of rats at different time after modeling subhepatic cholestasis. In this work, we used a material of 60 white male rats 200–250 g in weight. In experimental animals, the ligation of the common bile duct was carried out, in control animals – a false operation while maintaining a physiological bile flow in the duodenum throughout the experiment. Subhepatic cholestasis in rats is accompanied by an increase in the cortex cerebellum on the 2–20th days after the ligation of the common bile duct of the number of neurons with the increased c-fos-immunoreactivity, with the maximum one on the 10th day of the experiment. In surviving animals, after the removal of cholestasis in the long term (45–90 days), the number of neurons with the increased c-fos immunoreactivity, as well as the expression of this protein in neurons is normalized.

Biliary Excretion of Piperacillin

1983 ◽  
Vol 11 (1) ◽  
pp. 28-31 ◽  
Author(s):  
E W Taylor ◽  
V Poxon ◽  
J Alexander-Williams ◽  
D Jackson
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Biliary Excretion ◽  
Inhibitory Concentration ◽  
Bile Concentration ◽  
Urine Concentrations ◽  
The Common ◽  
Tract Infections ◽  
Serum And Urine

The excretion of piperacillin sodium in bile was studied after intravenous injection of 2 g (n = 5) and 4 g (n = 7). All patients had undergone cholecystectomy and exploration of the common bile duct for cholelithiasis. Bile, serum and urine concentrations were measured by a microbiological technique. Peak concentrations of piperacillin were found in bile at 150 minutes after 4 g and at 210 minutes after 2 g. Both the concentration of piperacillin in bile at the end of a 6 1/2 hour study and the calculated mean bile concentration of piperacillin were above the minimum inhibitory concentration (MIC) of this drug for organisms commonly found in acute biliary tract infections. We believe piperacillin may be useful in the management of such conditions.

Dynamics of bile flow through the human choledochal sphincter following exploration of the common bile duct

1989 ◽  
Vol 13 (3) ◽  
pp. 300-304 ◽  
Author(s):  
R. J. Holdsworth ◽  
S. A. Sadek ◽  
S. Ambikar ◽  
A. Cuschieri
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Bile Flow ◽  
Flow Through ◽  
The Common

Ultrasonography in diagnosis of the common bile duct pathology and pathology of the major duodenal papilla, complicated by mechanical jaundice

2021 ◽  
pp. 5-17
Author(s):  
Vladimir Alexandrovich Ivanov ◽  
Roman Nikolaevich Malushenko ◽  
Alexander Evgenievich Denisov ◽  
Elena Nikolaevna Kondrashenko
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Bile Flow ◽  
Clinical Syndrome ◽  
Review Of The Literature ◽  
Duodenal Papilla ◽  
Important Place ◽  
Major Duodenal Papilla ◽  
The Common ◽  
Diagnostic Capabilities

Mechanical jaundice is a clinical syndrome that develops due to the bile flow impairment along the bile ducts to the duodenum, remains one of the urgent problems of medicine. Of great importance among the causes of mechanical jaundice are diseases of the common bile duct and the major duodenal papilla, the diagnosis of which to this day remains a rather difficult task. The use of MRCP, ERСP, endo-ultrasonography and other highly informative bile tract imaging methods, despite great diagnostic capabilities, is associated with a number of limitations. In this regard, an important place, especially in the primary examination of patients, is occupied by transabdominal ultrasound, the advantages of which are non-invasiveness, portability, accessibility, safety, the possibility of multiple reiteration. A review of the literature presents domestic and foreign data of researchers regarding the possibility of ultrasonography in diagnostics of the common bile duct pathology and the pathology of the major duodenal papilla that are complicated by mechanical jaundice, as well as the greatest difficulties in diagnosing this pathology.

Cholangioscopy using the SpyGlass System for a Rare Cause of Obstruction: Inflammatory Polyp of the Common Bile Duct

2017 ◽  
Vol 26 (2) ◽  
pp. 111 ◽  
Author(s):  
Theodor Voiosu ◽  
Monica Ionita ◽  
Andrei Voiosu ◽  
Andreea Bengus ◽  
Cristiana Popp ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Inflammatory Polyp ◽  
The Common

.

Milk of Calcium in the Common Bile Duct: CT Identification

2002 ◽  
Vol 179 (3) ◽  
pp. 804-805 ◽  
Author(s):  
Joseph P. Mazzie ◽  
Burton M. Gold ◽  
Robert Bartolomeo ◽  
Douglas S. Katz
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Milk Of Calcium ◽  
The Common
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