The effects of acute hypercapnia on cerebral indole amine metabolism

1978 ◽  
Vol 56 (2) ◽  
pp. 223-226 ◽  
Author(s):  
V. MacMillan
Keyword(s):  
Monoamine Oxidase ◽  
Cerebral Hemisphere ◽  
Tryptophan Hydroxylase ◽  
Monoamine Oxidase Inhibition ◽  
Decarboxylase Inhibition ◽  
Amine Metabolism ◽  
Hydroxyindoleacetic Acid ◽  
Oxidase Inhibition ◽  
Increased Activity ◽  
Synthesis And Degradation

The effects of 1-h exposure to hypercapnia ([Formula: see text], 90–110 mmHg) on cerebral indole amine metabolism were studied in rats by measurement of cerebral hemisphere contents of tryptophan, 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA). 5-HIAA content was increased after 1-h exposure to hypercapnia, whereas tryptophan, 5-HTP, and 5-HT remained unchanged from control. The accumulation of 5-HTP after decarboxylase inhibition with 3-hydroxybenzyl hydrazine was increased in hypercapnic rats and indicated an increased activity of tryptophan hydroxylase. During the 1-h exposure to hypercapnia there was increased accumulation of 5-HT after monoamine oxidase inhibition with pargyline and increased accumulation of 5-HIAA arter probenecid. The results indicate an increased synthesis and degradation of indole amines in acute hypercapnia.

A Clinical and Biochemical Study of Monoamine Oxidase Inhibition in Depressed Patients

1961 ◽  
Vol 107 (447) ◽  
pp. 244-249 ◽  
Author(s):  
W. G. Dewhurst ◽  
C. M. B. Pare
Keyword(s):  
Monoamine Oxidase ◽  
Human Subject ◽  
Biochemical Study ◽  
Loading Dose ◽  
Monoamine Oxidase Inhibition ◽  
Enzyme Substrate ◽  
Before And After ◽  
Hydroxyindoleacetic Acid ◽  
Oxidase Inhibition ◽  
The Subject

In order to test whether a drug is an inhibitor of monoamine oxidase in the human subject, three main measures are available:1. We can measure an increased excretion of the normal substrates of the enzyme, e.g. tryptamine (Sjoerdsma, et al., 1959b).2. We can measure a decreased excretion of the metabolites resulting from the enzyme's action, e.g. 5-hydroxyindoleacetic acid (5-HIAA).3. We can administer a loading dose of an enzyme substrate and observe how the subject deals with it before and after the drug, e.g. 5-hydroxytryptamine (Sjoerdsma et al., 1958), and epinephrine (N-methyl-C14) (Resnick et al., 1958).

The effects of imidazole-4-acetic acid on cerebral indole amine metabolism

1982 ◽  
Vol 60 (3) ◽  
pp. 308-312
Author(s):  
V. MacMillan
Keyword(s):  
Acetic Acid ◽  
Steady State ◽  
Monoamine Oxidase ◽  
Cerebral Hemisphere ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Serotonin Metabolism ◽  
Decarboxylase Inhibitor ◽  
Amine Metabolism ◽  
Hydroxyindoleacetic Acid

The effects of imidazole-4-acetic acid (IMA, 100–400 mg/kg) on indole amine metabolism were studied by measurement of the cerebral hemisphere and brain stem contents of tryptophan, 5-hydroxytryptophan (5-HTP), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA). The results indicated that IMA does not alter the steady-state contents of brain indole amines. Furthermore, IMA failed to alter the levels of 5-HTP, 5-HT, or 5-HIAA in animals pretreated with 3-hydroxybenzyl hydrazine (a decarboxylase inhibitor), pargyline (a monoamine oxidase inhibitor), or probenecid (a compound which blocks 5-HIAA transport out of brain). These results suggest that altered serotonin metabolism is not a factor in the genesis of the behavioral or electroencephalographic changes produced by IMA.

Tyramine kinetics and pressor sensitivity during monoamine oxidase inhibition by selegiline

1989 ◽  
Vol 46 (5) ◽  
pp. 528-536 ◽  
Author(s):  
Rainer Schulz ◽  
Karl-Heinz Antonin ◽  
Edgar Hoffmann ◽  
Maria Jedrychowski ◽  
Eric Nilsson ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibition ◽  
Oxidase Inhibition

scholarly journals Glycaemic control by monoamine oxidase inhibition in a patient with type 1 diabetes

2016 ◽  
Vol 14 (2) ◽  
pp. 163-165 ◽  
Author(s):  
Hamlin Emory ◽  
Neptune Mizrahi
Keyword(s):  
Type 1 Diabetes ◽  
Glycaemic Control ◽  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Combined Treatment ◽  
Insulin Regimen ◽  
Imaging Data ◽  
Monoamine Oxidase Inhibition ◽  
Oxidase Inhibition

We present clinical, electroencephalographic and low-resolution electromagnetic tomography data that support combined treatment with insulin and a monoamine oxidase inhibitor in a patient with type 1 diabetes. We suggest that brain imaging data can identify a subgroup of patients who are likely to benefit from an insulin regimen and monoamine oxidase inhibition to improve glycaemic control, cardiovascular function, normalize the circadian rhythm and restore perception of glycaemic awareness.

scholarly journals 3,4-Dihydroxyphenylethanol (Hydroxytyrosol) Mitigates the Increase in Spontaneous Oxidation of Dopamine During Monoamine Oxidase Inhibition in PC12 Cells

2016 ◽  
Vol 41 (9) ◽  
pp. 2173-2178 ◽  
Author(s):  
David S. Goldstein ◽  
Yunden Jinsmaa ◽  
Patti Sullivan ◽  
Courtney Holmes ◽  
Irwin J. Kopin ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Pc12 Cells ◽  
Monoamine Oxidase Inhibition ◽  
Oxidase Inhibition ◽  
Spontaneous Oxidation
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