The blockade of serotonin uptake into synaptosomes: relationship to an interaction with monoamine oxidase inhibitors

1977 ◽  
Vol 55 (2) ◽  
pp. 180-187 ◽  
Author(s):  
John G. Sinclair ◽  
Grace F. Lo
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Monoamine Oxidase Inhibitors ◽  
Serotonin Uptake ◽  
Neuronal Uptake ◽  
5 Ht Uptake ◽  
Inhibition Of Neuronal Uptake ◽  
Depressant Drug

To test the hypothesis that the hyperpyrexia produced by meperidine and detromethorphan in rabbits pretreated with a monoamine oxidase inhibitor is related to inhibition of neuronal uptake of serotonin (5-hydroxytryptamine (5-HT)), fluoxetine (Lilly 110140) was studied. This potent and specific 5-HT neuronal uptake blocker was administered to phenelzine-pretreated rabbits and found to produce a lethal hyperpyrexia in doses equal to or greater than 2.5 mg/kg. The order of potency in blocking 5-[14C]HT uptake into synaptosomes prepared from rabbits was: fluoxetine > meperidine = dextromethorphan = levorphanol > anileridine > alphaprodine > morphine. Since fluoxetine, meperidine, and dextromethorphan produce hyperpyrexia in phenelzine-pretreated rabbits, whereas anileridine, alphaprodine, and morphine do not, there appears to be some correlation between the hyperpyrexic response and inhibition of 5-HT uptake. The exception is levorphanol, which is not hyperpyrexic despite being equipotent with meperidine and dextromethorphan in inhibiting 5-HT uptake. The ineffectiveness of levorphanol in producing hyperpyrexia may be due to its marked depressant properties, since the addition of another depressant drug (pentobarbital) antagonized the hyperpyrexic effect of meperidine.

Clinical Trial of Mebanazine—A New Monoamine Oxidase Inhibitor

1965 ◽  
Vol 111 (478) ◽  
pp. 899-902 ◽  
Author(s):  
S. J. G. Gilmour
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Monoamine Oxidase ◽  
Relapse Rate ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Monoamine Oxidase Inhibitors ◽  
Clinical Use ◽  
Clinical Toxicity

At the time when this investigation was being considered (June, 1961) the efficacy of the monoamine oxidase inhibitors in the treatment of depressive illnesses was already well recognized. It was also evident from a study of the published papers on this group of drugs that their use was accompanied by a number of side-effects which often raised problems in treatment. The clinical trial of a new drug of this class which, from the pre-clinical toxicity studies in animals, held promise of being less toxic than M.A.O. inhibitors already in clinical use was therefore considered worth while. Such a trial also seemed a useful opportunity to follow up previous observations with phenelzine (Gilmour, 1960) and the suggestion of Sargant (1961) that, given concurrently, M.A.O. inhibitors may potentiate the effect of E.C.T. and reduce the number of exposures necessary, and that their continuance after a course of E.C.T. has been completed may reduce the relapse rate.

Sudden Death Associated with Switching Monoamine Oxidase Inhibitors

1986 ◽  
Vol 20 (12) ◽  
pp. 954-956 ◽  
Author(s):  
Stephen R. Bazire
Keyword(s):  
Sudden Death ◽  
Monoamine Oxidase ◽  
Abrupt Change ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Monoamine Oxidase Inhibitors ◽  
Free Interval ◽  
Drug Free

A drug-free interval is often recommended when switching monoamine oxidase inhibitors, although the evidence firmly supporting this caution has been minimal. A case is reported where an abrupt change in monoamine oxidase inhibitor was followed by the death of a patient.

ACCUMULATION OF [14C]5-HYDROXYTRYPTAMINE IN THE PREGNANT RAT UTERUS AFTER TREATMENT WITH A MONOAMINE OXIDASE INHIBITOR

1969 ◽  
Vol 43 (3) ◽  
pp. 471-475 ◽  
Author(s):  
Z. KOREN ◽  
Y. PFEIFER ◽  
F. G. SULMAN
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Mao Inhibitor ◽  
Pregnant Rats ◽  
Pregnant Rat ◽  
Established Fact ◽  
Preferential Uptake ◽  
5 Ht Uptake ◽  
Umbilical Arteries

SUMMARY Intra-aortic injection of [3-14C]5-hydroxytryptamine creatinine sulphate ([14C]5-HT) into oestrogen or oestrogen-progestogen treated rats showed a pattern of homogeneous uptake similar to that found in untreated normal rats. In pregnant rats the injection resulted in a preferential uptake by the myometrium. Injection of a MAO inhibitor (pargyline hydrochloride, Eutonyl) into the amniotic sac, preceding the [14C]5-HT injection by 30 min., changed this pattern to a preferential accumulation in the myometrium and the spleen, perhaps due to unhampered transport of preserved 5-HT by the thrombocytes to the spleen. When [14C]5-HT was injected i.p. into the foetuses they retained high amounts of exogenous 5-HT. Myometrium and placenta also showed increased 5-HT uptake. This finding—taken together with the established fact that foetal 5-HT increases and placental monoamine oxidase decreases steadily up to term—suggests that at term the release of foetal 5-HT may enrich the maternal myometrium with 5-HT through the umbilical arteries without its entering the general blood circulation. It is also possible that additional maternal 5-HT may accumulate in the myometrium sensitized by the oestrogen surge at term. The importance of these mechanisms for the induction of labour is discussed.

Serotonin uptake inhibition by the monoamine oxidase inhibitor brofaromine

1993 ◽  
Vol 33 (5) ◽  
pp. 373-379 ◽  
Author(s):  
P.C. Waldmeier ◽  
T. Graf ◽  
M. Germer ◽  
J.J. Feldtrauer ◽  
H. Howald
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Serotonin Uptake ◽  
Uptake Inhibition ◽  
Serotonin Uptake Inhibition

Possible Monoamine Oxidase Inhibitor-Serotonin Uptake Inhibitor Interaction

1993 ◽  
Vol 13 (5) ◽  
pp. 312???320 ◽  
Author(s):  
CHAELES M. BEASLEY ◽  
DANIEL N. MASICA ◽  
JOHN H. HEILIGENSTEIN ◽  
DAVID E. WHEADON ◽  
ROBERT L. ZERBE
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor ◽  
Serotonin Uptake ◽  
Uptake Inhibitor ◽  
Serotonin Uptake Inhibitor ◽  
Inhibitor Interaction

Possible antidepressant/mania-inducing effects of methionine: a reappraisal of the effects of methionine in chronic psychosis using modern diagnostic criteria

1989 ◽  
Vol 4 (3) ◽  
pp. 175-181
Author(s):  
J.F. Lipinski ◽  
R.C. Alexander
Keyword(s):  
Monoamine Oxidase ◽  
Diagnostic Criteria ◽  
Monoamine Oxidase Inhibitor ◽  
Manic Episode ◽  
Oxidase Inhibitor ◽  
Descriptive Data ◽  
Antidepressant Effects ◽  
Chronic Psychosis

SummaryThe authors have reviewed 13 published studies on methionine administration, usually in combination with a monoamine oxidase inhibitor (MAOI), to chronically psychotic patients, using modern (DSM-III) diagnostic criteria. Four of these studies contained sufficient descriptive data to allow reappraisal of the effects. The results of the review suggest that a proportion of the patients experienced the induction of a manic episode/antidepressant effects rather than the reported worsening of schizophrenia while treated with a methionine-MAOI combination. It is suggested that these observations are consistent with recent findings that S-adenosyl-L-methionine (SAMe) has antidepressant and mania-inducing effects.

ROLE OF AN ENDOGENOUS MONOAMINE OXIDASE INHIBITOR, ISATIN, IN SHRSP BRAIN

1995 ◽  
Vol 22 (s1) ◽  
pp. S86-S87 ◽  
Author(s):  
N. Hamaue ◽  
T. Endo ◽  
M. Hirafuji ◽  
N. Yamazaki ◽  
H. Togashi ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor

Monoamine oxidase inhibitor usage in Hawaii

2010 ◽  
Vol 3 (4) ◽  
pp. 213-215
Author(s):  
Junji Takeshita ◽  
Deborah Goebert ◽  
John Huh ◽  
Brett Lu ◽  
Diane Thompson ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor

Identification of Kaempferol as a Monoamine Oxidase Inhibitor and Potential Neuroprotectant in Extracts ofGinkgo BilobaLeaves

2000 ◽  
Vol 52 (4) ◽  
pp. 451-459 ◽  
Author(s):  
B. D. SLOLEY ◽  
L. J. URICHUK ◽  
P. MORLEY ◽  
J. DURKIN ◽  
J. J. SHAN ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase Inhibitor ◽  
Oxidase Inhibitor
Sign in / Sign up

Export Citation Format

Share Document