The Influence of [3H]Taurocholate on the Biliary Excretion of [14C]Acetylprocaine Amide Ethobromide

1975 ◽  
Vol 53 (5) ◽  
pp. 888-894 ◽  
Author(s):  
S. H. Kuo ◽  
G. E. Johnson
Keyword(s):  
Biliary Excretion ◽  
Concentration Ratio ◽  
Jugular Vein ◽  
Sodium Taurocholate ◽  
Concomitant Administration ◽  
Plasma Concentration Ratio ◽  
Male Wistar Rats ◽  
The Common ◽  
Excretion Rates ◽  
Bile Samples

The biliary excretion rates of [14C]acetylprocaine amide ethobromide (acetyl-PAEB) and [3H]taurocholate, either administered alone or in combination to adult male Wistar rats, were studied. Their renal pedicles were ligated, and the common bile duct and one jugular vein cannulated. Acetyl-PAEB, 20 mg/kg, and sodium taurocholate, 70 mg/kg, were infused over a 5-min period. Blood and bile samples were collected every 10 min for 60 min. Liver samples were taken at 10 and 20 min. Approximately 100% of the administered taurocholate was excreted within 50 min. The simultaneous administration of acetyl-PAEB did not significantly alter the taurocholate excretion. The amount of the acetyl-PAEB dose excreted in 1 h was 9.4%. This was increased significantly to 16.5% when taurocholate was given concomitantly. The concentration of acetyl-PAEB in the bile increased significantly when taurocholate was given, and the ratios of its concentrations in bile–liver and bile–plasma were also increased. Taurocholate did not alter the liver–plasma concentration ratio of acetyl-PAEB. It is suggested that the concomitant administration of taurocholate increased the biliary excretion of acetyl-PAEB by facilitating its secretion by the liver into the bile.

Multiple Hepatic Excretory Mechanisms for Organic Anions. A Study with Succinylsulfathiazole and Taurocholate in the Rat

1975 ◽  
Vol 53 (1) ◽  
pp. 97-103 ◽  
Author(s):  
D. G. Bailey ◽  
G. E. Johnson
Keyword(s):  
Transport System ◽  
Intravenous Administration ◽  
Biliary Excretion ◽  
Plasma Proteins ◽  
Bile Flow ◽  
Plasma Concentrations ◽  
Concomitant Administration ◽  
Organic Anions ◽  
Excretion Rates ◽  
Acidic Compounds

A study was done to investigate interactions in the biliary excretion of [14C] succinylsulfathiazole and [3H]taurocholate after intravenous administration of the two compounds to anesthetized rats. Either compound administered alone increased bile flow and was excreted in the bile. The simultaneous infusion of both significantly increased bile flow above the values seen when either was given alone. However, the biliary-excretion rates of both compounds and their concentrations in bile were reduced when they were administered concomitantly. The simultaneous injection of radioactive taurocholate and succinylsulfathiazole did not alter significantly the plasma concentrations of either compound or their binding to plasma proteins from the values obtained when each was given alone. These results are consistent with a concept of competition between these compounds for the same liver-to-bile transport system. They contrast with previous observations that indicated that the concomitant administration of taurocholate increased the biliary excretion of acidic compounds. In the light of this work, it might be suggested that there are more than one transport system for the biliary excretion of organic anions.

Biliary excretion of digitoxin and its metabolites in young and old male wistar rats

1982 ◽  
Vol 17 (6) ◽  
pp. 407-416 ◽  
Author(s):  
K KITANI ◽  
S KANAI ◽  
Y SATO ◽  
M NOKUBO
Keyword(s):  
Biliary Excretion ◽  
Wistar Rats ◽  
Male Wistar Rats

Aqueous extract of Cola nitida and Garcinia kola synergistically enhances hippocampal-hypothalamic glutamate and Na+/K+-ATPase activity in male Wistar rats

2021 ◽  
Vol 18 ◽  
Author(s):  
Kehinde S. Olaniyi ◽  
Isaiah W. Sabinari ◽  
Adesola A. Oniyide ◽  
Nifesimi T. Akinnagbe ◽  
Toluwani B. Agunbiade ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Wistar Rats ◽  
Concomitant Administration ◽  
Energy Regulation ◽  
Aqueous Extracts ◽  
Garcinia Kola ◽  
Or Management ◽  
Male Wistar Rats ◽  
Susceptible Populations ◽  
Cola Nitida

Background: The incidence of cognitive decline has been proposed to rise exponentially in coming years. Therapies targeting molecular pathways involved in enhancement of memory and energy regulation could be a major breakthrough in prevention or management of dementia in susceptible populations. Objectives: This study investigated the effects of aqueous extracts of Cola nitida (AECONS) and Garcinia kola (AEGAK) on glutamate level and Na+/K+-ATPase activity in the hippocampus and hypothalamus of male Wistar rats. Methods: Adult male Wistar rats (170-200) were randomly allotted into groups (n=5/group); control (distilled water p.o.), AECONS1 (200 mg/kg), AECONS2 (400 mg/kg), AEGAK1 (200 mg/kg), AEGAK2 (400 mg/kg), AECONS1+AEGAK1 and AECONS2+AEGAK2. The extract was prepared and the administration was done daily for 6 weeks. Results and Discussion: Administration of AECONS or AEGAK increased plasma, hippocampal and hypothalamic glutamate, Na+/K+-ATPase activity, NO, SOD except hippocampal glutamate in AECONS1/AEGAK1, Na+/K+-ATPase activity and SOD in AEGAK1, hypothalamic glutamate and SOD in AECONS1 when compared with control. Besides, MDA level decreased in AEGAK2 and hippocampal but not hypothalamic MDA decreased in AEGAK1 compared with control. However, concomitant administration of AECONS and AEGAK enhanced plasma, hippocampal and hypothalamic biomarkers except hypothalamic MDA level. The present study demonstrates that AECONS and AEGAK synergistically enhances hippocampal and hypothalamic glutamate and Na+/K+-ATPase activity, which are accompanied by NO and SOD-dependent antioxidant enrichment. Conclusion: These findings therefore suggest that AECONS+AEGAK could be a better therapeutic candidate in hippocampal-hypothalamic-related neurodegenerative diseases.

scholarly journals Termination of the facial vein into the external jugular vein: an anatomical variation

2008 ◽  
Vol 7 (2) ◽  
pp. 174-175 ◽  
Author(s):  
Suhani Sumalatha D'Silva ◽  
Thejodhar Pulakunta ◽  
Bhagath Kumar Potu
Keyword(s):  
Jugular Vein ◽  
Anatomical Variation ◽  
Venous Drainage ◽  
External Jugular Vein ◽  
Facial Artery ◽  
Drainage Pattern ◽  
Facial Vein ◽  
The Face ◽  
The Common ◽  
Anterior Division

Different patterns of variations in the venous drainage have been observed in the past. During routine dissection in our Department of Anatomy, an unusual drainage pattern of the veins of the left side of the face of a middle aged cadaver was observed. The facial vein presented a normal course from its origin up to the base of mandible, and then it crossed the base of mandible posteriorly to the facial artery. Thereafter, it joined with the anterior division of retromandibular vein to form the common facial vein, which drained into the external jugular vein directly. Sound anatomic knowledge of the above variation in facial veins is essential to the success of surgical procedures in this region.

scholarly journals Effects of Long-Term Administration of Lithium and Hydrochlorothiazide in Rats

1999 ◽  
Vol 6 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Felicia Loghin ◽  
Adriana Olinic ◽  
Daniela-Saveta Popa ◽  
Carmen Socaciu ◽  
Sorin E. Leucuta
Keyword(s):  
Wistar Rats ◽  
Histopathological Examination ◽  
Concomitant Administration ◽  
Histological Changes ◽  
Association Group ◽  
Term Administration ◽  
Male Wistar Rats ◽  
Kidney Liver ◽  
Lithium Lactate

The biochemical and histological changes following 60 days administration of daily doses equivalent to 1/20 LD50 of lithium lactate and hydrochlorothiazide, as such and in association, were studied in male Wistar rats. No mortality or overt signs of toxicity were observed during the experiment and the serum activities of transaminases, alkaline phosphatase and cholinesterase were not significantly modified compared to controls. The histopathological examination of all the investigated organs: kidney, liver, brain and spleen, revealed significant lesions which were time-dependant and more pronounced in the association group. Although the changes were mostly inflammatory and conqestive, it was proved that the concomitant administration of lithium and hydrochlorothiazid is potentially dangerous, increasing lithium’s nephrotoxicity and the thiazide diuretic's hepatotoxicity.

scholarly journals Arterial Placement of Central Venous Catheters

2020 ◽  
Vol 15 (3) ◽  
pp. 45-48
Author(s):  
Benjamin Wierstra ◽  
Selena Au ◽  
Paul Cantle ◽  
Kenton Rommens
Keyword(s):  
Internal Jugular Vein ◽  
Jugular Vein ◽  
Posterior Wall ◽  
Arterial Injury ◽  
Central Venous Catheters ◽  
Ultrasound Guided ◽  
Central Venous ◽  
Carotid Injury ◽  
Radiologie Interventionnelle ◽  
The Common

Arterial misplacement of central venous catheters can often be avoided with the use of real-time ultrasound-guided procedural competency.  However, misplacement can still occur and is more likely to occur when the internal jugular vein is located directly above the common carotid injury.  The resultant injury to the common carotid artery occurs through the posterior wall of the internal jugular vein.  Arterial injury may also occur when the subclavian vein is attempted in a non-ultrasound-guided fashion.  Optimal management requires a coordinated evaluation of the catheter misplacement by Interventional Radiology and Vascular Surgery to ensure maximum patient safety during catheter removal.  This article reviews the literature around this topic and provides a summary of the best approach to safely remove the misplaced catheter. Resume Le mauvais positionnement artériel des cathéters veineux centraux peut souvent être évité grâce à l'utilisation de compétences procédurales guidées par ultrasons en temps réel.  Cependant, un mauvais positionnement peut toujours se produire et est plus susceptible de se produire lorsque la veine jugulaire interne est située directement au-dessus de la lésion carotidienne commune.  La lésion de l'artère carotide commune qui en résulte se produit à travers la paroi postérieure de la veine jugulaire interne.  Une lésion artérielle peut également se produire lorsque la veine sous-clavière n'est pas guidée par un ultrason.  Une gestion optimale nécessite une évaluation coordonnée du mauvais positionnement du cathéter par la radiologie interventionnelle et la chirurgie vasculaire afin de garantir une sécurité maximale au patient lors du retrait du cathéter.  Cet article passe en revue la littérature sur ce sujet et fournit un résumé de la meilleure approche pour retirer en toute sécurité le cathéter mal placé.  

scholarly journals Common Deletion (CD) in mitochondrial DNA of irradiated rat heart

2014 ◽  
Vol 86 (2) ◽  
pp. 685-694 ◽  
Author(s):  
RAQUEL G. SIQUEIRA ◽  
DAYSE A. DA SILVA ◽  
LUIZ D.B. DE MELO ◽  
ELIZEU F. DE CARVALHO ◽  
SAMARA C. FERREIRA-MACHADO ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Ionizing Radiation ◽  
Real Time ◽  
Real Time Pcr ◽  
Rat Heart ◽  
Wistar Rats ◽  
Post Irradiation ◽  
Male Wistar Rats ◽  
The Common ◽  
Common Deletion

The purpose of this study was to map the common deletion (CD) area in mtDNA and investigate the levels of this deletion in irradiated heart. The assays were developed in male Wistar rats that were irradiated with three different single doses (5, 10 or 15 Gy) delivered directly to the heart and the analyses were performed at various times post-irradiation (3, 15 or 120 days). The CDs area were sequenced and the CD quantified by real-time PCR. Our study demonstrated that the CD levels progressively decreased from the 3rduntil the 15th day after irradiation, and then increased thereafter. Additionally, it was observed that the levels of CD are modulated differently according to the different categories of doses (moderate and high). This study demonstrated an immediate response to ionizing radiation, measured by the presence of mutations in the CD area and a decrease in the CD levels.

scholarly journals Variations in the anatomical relationship between the common carotid artery and the internal jugular vein: An ultrasonographic study

2015 ◽  
pp. 54-59 ◽  
Author(s):  
Mauricio Umaña Perea ◽  
Alberto Federico García ◽  
José Luis Castillo García ◽  
Luis Alfonso Bustamante Cristancho ◽  
Juan Sebastián Martínez Collazos
Keyword(s):  
Multivariate Analysis ◽  
Carotid Artery ◽  
Internal Jugular Vein ◽  
Common Carotid Artery ◽  
Jugular Vein ◽  
Patients Âgés ◽  
Anterior Position ◽  
Anatomical Relationship ◽  
The Common ◽  
The Right

Introduction: The internal jugular vein locates anterior or anterolateral to the common carotid artery in two-thirds of the subjects studied by ultrasound when the head is in a rotated position. Aim: To identify variables associated with the anterior location of the internal jugular vein. Methods: Ultrasound examinations were performed with the patients in the supine position, with the head rotated to the opposite side. The proximal third of the neck was visualized transversely with a 7.5-mHz transducer. The relationship between the vessels was described in accordance with the proportion of the artery overlapped by the vein. Univariate comparisons and a multivariate analysis of potential variables that may affect the anatomic relationships were performed. Results: Seventy-eight patients were included, 44 of whom were men. The patients' ages ranged from 17 to 90 years (median 64.0, interquartile range 41-73). The right and left sides were studied 75 and 73 times, respectively. The vein was located lateral to the artery in 24.3% (95%CI= 17.4-32.2) of the studies, anterolateral in 33.8% (95%CI= 26.2-41.4) and anterior in 41.9% (95%CI= 33.9-49.8). The multivariate analysis identified age group (OR= 3.7, 95% CI 2.1-6.4) and, less significantly, the left side (OR= 1.7, 95%CI= 0.8-3.5) and male gender (OR= 1.2, 95%CI= 0.6-2.7) as variables associated with the anterior position of the vein. Conclusión: The anterior position of the internal jugular vein relative to the common carotid artery increases gradually with age. Additionally, left-sided localization and male sex further increased the probability of an anterior position.

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