A New Prolonged-Acting Type of Chlorpromazine: Behavioral Effects and Prolonged Actions on Nerve Membranes

A chlorethyl derivative of chlorpromazine was prepared (2-chlor-10-(3-(beta-chlor-ethyl)-methylammopropyl)-phenothiazine HCl). This drug stabilized human erythrocytes (from hypotonic hemolysis) in the micromolar concentration range and had prolonged nerve-blocking potency. By using a 14C-labelled form of this drug, it was found to adhere persistently to both erythrocyte and brain synaptosome membranes. In animal behavior tests, the drug (P-B 845 Cl) was about one-fourth the potency of chlorpromazine. There is a possibility that the drug may have some long-term action since the animals recovered more slowly from the antiamphetamine actions of P-B 845 Cl than from the anti-amphetamine actions of chlorpromazine.