The effect of destruction of the bundle of His or the atrioventricular node on cyclopropane–adrenaline cardiac arrhythmias

1970 ◽  
Vol 48 (4) ◽  
pp. 207-215 ◽  
Author(s):  
Betty I. Sasyniuk ◽  
Peter E. Dresel

Destruction of the bundle of His abolished bigeminal rhythms produced by adrenaline in thiopentone–cyclopropane anesthetized dogs. Bigeminal rhythms were still elicited, however, after selective destruction of the A–V node. Destruction of the bundle of His did not prevent multifocal arrhythmias but did increase the dose of adrenaline required to induce them. Multifocal arrhythmias produced after destruction of the bundle of His were abolished by injections of acetylcholine into the left anterior descending, but not the circumflex coronary artery, results opposite to those obtained in normal hearts.

1964 ◽  
Vol 42 (5) ◽  
pp. 627-639 ◽  
Author(s):  
Keith L. MacCannell ◽  
Peter E. Dresel

Thiopental has been used for induction of anaesthesia in most, experimental and clinical investigations of cyclopropane–adrenaline cardiac arrhythmias. We have compared the effects of adrenaline under cyclopropane (cyclo) anaesthesia in dogs with those observed under thiopental (thio) anaesthesia and thiopental–cyclopropane (thio–cyclo) anaesthesia. Bigeminal rhythm occurring in response to small doses of adrenaline is observed in less than half the animals under cyclo or thio anaesthesia, but is observed in over 90% when the two anaesthetic agents are present. The dose of adrenaline necessary to produce multifocal or ventricular fibrillatory rhythms also appears to be greater under cyclo than under thio–cyclo, but exact quantification is difficult because of the rapid development of tachyphylaxis to larger doses of adrenaline. The duration of the effect of thiopental outlasts by many hours its usual anaesthetic action. Intravenous injections of "subeffective" doses of adrenaline produce bigeminal rhythm if they are preceded by injection of small doses of thiopental into the left circumflex coronary artery. This rarely occurs if thiopental is injected into the left anterior descending coronary artery. Previous evidence has suggested that the bigeminal beat arises in the atrioventricular node or upper bundle of His and that the left circumflex coronary artery supplies this area. It is thus probable that thiopental exerts its action in the upper part of the conduction system. It is concluded that induction of anaesthesia with thiopental plays a considerable role in the "cyclopropane–adrenaline" cardiac arrhythmias described in the literature.


2018 ◽  
Vol 19 ◽  
pp. e34
Author(s):  
S. Nicolardi ◽  
G. Scrascia ◽  
F. Mangia ◽  
A. Gallo ◽  
L. Amorese ◽  
...  

2016 ◽  
pp. 20-24
Author(s):  
Bang Giap Vo ◽  
Anh Binh Ho ◽  
Van Minh Huynh

Objectives: To investigate the features of coronary artery lesions in patients over 50 with heart valve diseases and to find out the relationship between the levels of coronary artery lesions and heart valve diseases. Results: In patients over 50 year old with heart valve diseases, the rate of significant coronary artery lesions is 55.5%. In which, significant lesions in the group of both mitral and aorta valve diseases is 44.19%, only mitral valve diseases is of 70%, only aortic valve diseases is of 51.85%. There is a relationship between the severity of mitral valve diseases and right coronary artery lesions (OR 3.74: 1.64 to 8.5, p = 0.0017) and circumflex coronary artery lesions (OR 2.59: 1.16 to 5.75, p = 0.0192). The severity of heart valve lesions in significant coronary artery lesions group is higher than insignificant coronary artery lesions group or normal group. Conclusion: Coronary artery lesions is common in patients > 50 years old with heart valve diseases, there is a relationship between the severity of mitral valve diseases and and right coronary artery lesions and circumflex coronary artery lesions. Key words: coronary artery lesions, mitral valvediseases


Author(s):  
Asli Tanrivermis Sayit ◽  
Cetin Celenk

<P>Background: Hypoplastic coronary artery disease is a rare congenital coronary artery anomaly. It is often detected incidentally, and its true incidence in the general population is not known. </P><P> Discussion: Symptoms of HCAD are syncope, palpitations, dyspnea, and chest pain. Also, arrhythmia and myocardial infarction can be seen; these can cause sudden death, especially in athletes and young people. Diagnosis is often made at autopsy. Conclusion: Here, we present the case of a 39-year-old male with isolated hypoplasia of the left circumflex artery detected by coronary Computed Tomography (CT) angiography who complained of palpitation.</P>


1974 ◽  
Vol 17 (3) ◽  
pp. 210-214
Author(s):  
Banning G. Lary ◽  
Roger W. Sherman ◽  
Sonya S. Glasser ◽  
Joan McDermott ◽  
Frank Gollan

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