Effect of long-term treatment with an anticholinergic drug on parietal cell mass in rats

1969 ◽  
Vol 47 (4) ◽  
pp. 402-405
Author(s):  
K. Kowalewski
Keyword(s):  
Body Weight ◽  
Parietal Cell ◽  
Anticholinergic Drug ◽  
Cell Mass ◽  
Term Treatment ◽  
Parietal Cells ◽  
Long Term Treatment ◽  
Propantheline Bromide

An anticholinergic drug, propantheline bromide, was given to rats in a dosage of 5 mg/kg body weight twice daily, for 6, 9, or 12 months. Parietal cell mass was determined in these animals and in controls of similar age and weight. A significant decrease in the number of parietal cells was found in the stomachs of treated rats. This was considered to represent an "inhibition hypoplasia" produced experimentally.

scholarly journals Effect of guar gum on body-weight, hunger ratings and metabolism in obese subjects

1984 ◽  
Vol 52 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Marcin Krotkiewski
Keyword(s):  
Body Weight ◽  
Dietary Habits ◽  
Guar Gum ◽  
Term Treatment ◽  
Total Serum ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Long Term Treatment ◽  
Obese Subjects

1. The effect of a palatable granulated guar-gum preparation (10 g twice daily) was studied in obese subjects. The acute effect of a single dose of guar gum to reduce the peak postprandial whole blood glucose levels (about 10%) was verified. Following long-term treatment, a further reduction was seen in the obese subjects with the highest postprandial glucose levels. Since the postprandial plasma insulin levels were essentially unchanged, this finding suggested an increased responsiveness to insulin. Total serum cholesterol levels were significantly reduced following long-term treatment but serum α-cholesterol levels, representing the high-density-lipoprotein fraction, was unchanged.2. Body-weight was significantly reduced during guar-gum treatment even though the patients were asked to maintain their normal dietary habits. Daily hunger ratings recorded for up to 10 weeks showed that guar gum reduced hunger significantly better than commercially available bran taken in the same way.3. Thus, guar gum seemed to influence carbohydrate and lipid metabolism in a beneficial way in obese subjects. The reduction in hunger would offer an additional benefit to these patients.

CORTICOSTEROIDS AND VASCULAR CONNECTIVE TISSUE

1969 ◽  
Vol 60 (4) ◽  
pp. 586-594 ◽  
Author(s):  
Ib Lorenzen
Keyword(s):  
Body Weight ◽  
Connective Tissue ◽  
Human Skin ◽  
Term Treatment ◽  
Collagen Content ◽  
Acid Mucopolysaccharides ◽  
Long Term Treatment

ABSTRACT Male albino rabbits were injected with prednisone 2 mg/kg body weight, daily for two weeks. The aortic content of acid mucopolysaccharides and the synthesis of sulphated acid mucopolysaccharides decreased, whereas the collagen content remained unchanged as compared to the saline injected controls. Prednisone induced no gross or microscopic changes in the aortae. The alterations were related to those previously reported in human skin and vein biopsies and may be of pathogenic significance in the vascular fragility following long-term treatment with glucocorticoids.

scholarly journals Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

2009 ◽  
Vol 78 (8) ◽  
pp. 951-958 ◽  
Author(s):  
Edson Lucas Santos ◽  
Kely de Picoli Souza ◽  
Elton Dias da Silva ◽  
Elice Carneiro Batista ◽  
Paulo J. Forcina Martins ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Life Span ◽  
Ace Inhibitor ◽  
Body Weight Gain ◽  
Term Treatment ◽  
Long Term Treatment

LONG-TERM TREATMENT WITH ORAL TORSEMIDE AND ITS EFFECT ON BODY WEIGHT AND FLUID BALANCE IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY

1996 ◽  
Vol 3 (11) ◽  
pp. 743-749
Author(s):  
Andrew Whelton ◽  
William B. Smith ◽  
J. David Wallin ◽  
Lawrence J. Hak ◽  
Barry McLean ◽  
...  
Keyword(s):  
Body Weight ◽  
Renal Insufficiency ◽  
Fluid Balance ◽  
Chronic Renal Insufficiency ◽  
Term Treatment ◽  
Long Term Treatment

BODY CELL MASS DURING LONG-TERM CORTISONE TREATMENT IN ASTHMATIC SUBJECTS

1967 ◽  
Vol 55 (2) ◽  
pp. 202-221 ◽  
Author(s):  
Björn Lindholm
Keyword(s):  
Body Weight ◽  
Cell Mass ◽  
Body Cell Mass ◽  
Exchangeable Potassium ◽  
Male And Female ◽  
Body Cell ◽  
Long Term Treatment ◽  
Cortisone Therapy ◽  
Female Subjects

ABSTRACT The body cell mass (BCM) was estimated from determinations of the total exchangeable potassium (Ke) in 66 patients with severe bronchial asthma requiring long-term treatment with daily doses of glucocorticoids equivalent to 25–75 mg of cortisone. Thirty subjects had been treated with cortisone for more than six years (2–12 years) prior to the present study. The remaining thirty-six patients were studied at the beginning of the cortisone treatment period. Twenty-two patients from both groups were followed during more than two years of daily cortisone therapy by repeated, paired Ke-determinations. Ke was determined by the isotope dilution technique. In all, 297 such determinations were performed by oral administration of 42K, allowing the isotope to equilibrate for 45 hours. The initial body content of Ke in male and female subjects with or without several years of previous cortisone therapy did not differ from normal subjects, when related to body weight and age. A statistical analysis revealed a significant increase in the total exchangeable potassium of both male and female subjects during treatment with cortisone. None of the patients showed significantly decreasing Ke-values during the longitudinal study. Body weight showed a covariation with Ke but did not, on an average, increase significantly with time. Cortisone induced osteoporosis was found in twelve subjects. Taken as a group, these subjects showed normal values of Ke, when related to body weight and age. Apparently, bone atrophy can develop during cortisone treatment without concomitant atrophy of the BCM.

scholarly journals Fine Structural and Morphometric Studies on Gastric Parietal Cells of Peptic Ulcer Patients after Long-Term Treatment with Omeprazole.

1998 ◽  
Vol 61 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Hiroko KOBAYASHI ◽  
Tsuyoshi WATANABE ◽  
Akira NAKAHARA ◽  
Hiroshi MUTOH ◽  
Naomi TANAKA ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Term Treatment ◽  
Parietal Cells ◽  
Long Term Treatment ◽  
Gastric Parietal Cells

1400 EFFECTS OF LONG-TERM TREATMENT WITH TESTOSTERONE UNDECANOATE INJECTIONS IN HYPOGONADAL MEN ON WAIST CIRCUMFERENCE, BODY WEIGHT AND BMI

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Dany-Jan Yassin ◽  
Ahmad Haider ◽  
Michael Zitzmann ◽  
Aksam Yassin ◽  
Peter Hammerer ◽  
...  
Keyword(s):  
Body Weight ◽  
Waist Circumference ◽  
Term Treatment ◽  
Testosterone Undecanoate ◽  
Long Term Treatment
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