The comparative effect of reserpine and carbethoxysyringoyl methylreserpate (Su 3118) upon the menstrual cycle of the rhesus monkey

1969 ◽  
Vol 47 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Lloyd B. Erikson
Keyword(s):  
Menstrual Cycle ◽  
Rhesus Monkeys ◽  
Winter Season ◽  
Vaginal Smears ◽  
Comparative Effect ◽  
Menstrual Cycles ◽  
Proliferative Phase ◽  
Significant Difference ◽  
Female Rhesus ◽  
Estrogen Withdrawal

Female rhesus monkeys were treated with either reserpine or carbethoxysyringoyl methylreserpate (Su 3118) during the proliferative phase (days 2 through 12) of the menstrual cycle, at the time of the year (fall–winter season) when menstrual cycles were very regular. When reserpine was given at dosages of 1.0, 0.5, and 0.2 mg/kg body weight, 11 out of 17 menstrual cycles were prolonged. When carbethoxysyringoyl methylreserpate was given at similar dosage, 6 out of 15 menstrual cycles were prolonged, and no significant difference in comparative effectiveness of the two drugs was found. Data from vaginal smears and washes were presented to suggest that drug action was mediated through an estrogen-withdrawal effect. Since the former drug has marked tranquilizing property while the latter drug does not, it would appear that marked tranquilization is not a prerequisite for this endocrinopathy.

Reproductive endocrine effects of intranasal administration of progesterone to adult female rhesus monkeys

1985 ◽  
Vol 110 (4) ◽  
pp. 461-468 ◽  
Author(s):  
G. F. X. David ◽  
V. Puri ◽  
A. K. Dubey ◽  
C. P. Puri ◽  
T. C. Anand Kumar
Keyword(s):  
Menstrual Cycle ◽  
Phase Ii ◽  
Adult Female ◽  
Rhesus Monkeys ◽  
Intranasal Administration ◽  
Type I ◽  
Luteal Function ◽  
Menstrual Cycles ◽  
Female Rhesus ◽  
Endocrine Profile

Abstract. Adult female rhesus monkeys exhibiting normal ovulatory menstrual cycles were treated with progesterone nasal sprays. Animals in group A (n = 9) were treated with the solvent only (controls). Animals in groups B (n = 6), C (n = 17) and D (n = 7), respectively, were treated with a daily dose of 0.4, 2 and 10 μg of progesterone and the spraying was done between days 5–14 of the cycle. Ovulation was monitored by laparoscopy on day 20. The serum endocrine profile throughout the treated menstrual cycle was studied with respect to oestradiol and progesterone. Bioactive luteinizing hormone (bLH) was studied in blood samples taken on the day of the mid-cycle oestradiol peak, 2 days before, and 2 days after. The menstrual cycle was divided into two phases with respect to the mid-cycle oestradiol peak: phase I was taken to include day 1 of the cycle to the day of the oestradiol peak, and the remaining part of the menstrual cycle was considered to be phase II. The serum-endocrine profile in the controls was similar to that observed in normal ovulatory menstrual cycles. However, in the progesterone-treated groups three types of menstrual cycles were discernable on the basis of the serum endocrine profile. In the type I menstrual cycle, observed only in group C (n = 10), the mid-cycle bLH peak was abolished and the progesterone levels remained low throughout the cycle. Laparoscopy revealed these to be anovulatory cycles. In the type II menstrual cycle, seen in the 3 animals of group B, 2 animals of group C, and in all the 7 animals of group D, the mid-cycle bLH peak was abolished and the progesterone levels during phase II of the cycle were significantly lower than in the controls, indicative of poor luteal function. In the type III menstrual cycle seen in the remaining monkeys, the serum endocrine profile did not differ from that seen in the controls. Thus, the present studies indicate that the intranasal administration of progesterone shows a dose-response effect with respect to the suppression of the oestradiol induced mid-cycle surge of bLH. Suppression of the mid-cycle bLH peak resulted in anovulatory cycles or ovulatory cycles with poor luteal function.

THE NUMBER OF OOCYTES IN THE MATURE RHESUS MONKEY (MACACA MULATTA)

1951 ◽  
Vol 7 (2) ◽  
pp. 194-202 ◽  
Author(s):  
S. H. GREEN ◽  
S. ZUCKERMAN
Keyword(s):  
Statistical Analysis ◽  
Menstrual Cycle ◽  
Rhesus Monkey ◽  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Significant Difference ◽  
Average Total Number ◽  
Sexually Mature

Estimates have been made of the total number of oocytes in ovaries removed on different days of the menstrual cycle from twelve sexually mature rhesus monkeys. They have been analysed on two assumptions: (a) that no relation exists over the range of age studied between age and the number of oocytes present; and (b) that such a relation exists. The data were grouped in the following three temporal phases of the menstrual cycle: days 1–9, days 10–18, days 19–27. Statistical analysis failed to reveal any significant difference between the average total number of oocytes present at the beginning, the middle, or the end of the menstrual cycle.

scholarly journals The Influence of BMI Levels on Phases of the Menstrual Cycle and Presumed Ovulation

2012 ◽  
Vol 79 (4) ◽  
pp. 451-459
Author(s):  
Mary Grace Lasquety ◽  
Dana Rodriguez ◽  
Richard J. Fehring
Keyword(s):  
Body Mass Index ◽  
Menstrual Cycle ◽  
Odds Ratio ◽  
Luteal Phase ◽  
High Body Mass Index ◽  
Normal Weight ◽  
Menstrual Cycles ◽  
Significant Difference ◽  
Overweight Group ◽  
One Way Anova

Obesity and high body mass index (BMI) are known to be risks for anovulation and infertility. Little is known about how BMI levels affect parameters of the menstrual cycle. The purpose of this study was to determine the influence of BMI on parameters of the menstrual cycle and the likelihood for ovulation. The participants in this study were 244 women between the ages of twenty and fifty-four (mean thirty years) who charted from one to thirty-six menstrual cycles (mean seven cycles) for a total of 2,035 cycles. Urinary luteinizing hormone (LH) threshold tests were used to estimate the day of ovulation and the lengths of the follicular and luteal phases. The 244 participants were classified as normal weight with a BMI of 18.5–24.9 kg/m2 (N = 141), overweight with a BMI of 25–29.9 kg/m2 (N = 67), and obese with a BMI of 30 kg/m2 or greater (N = 36). One-way ANOVA indicated that there was a significant difference between groups in length of the luteal phase (F = 4.62, p < 0.01) and length of menses (F = 3.03, p < 0.05). Odds ratio indicated that the combined obese and overweight group was 34 percent less likely to have a positive detected urinary LH surge. We concluded that obesity might contribute to infertility by shortening the luteal phase and decreasing the probability of ovulatory menstrual cycles.

scholarly journals Is body mass index associated with irregular menstruation: A questionnaire study?

2020 ◽  
Author(s):  
Yunhui Tang ◽  
Yan Chen ◽  
Hua Feng ◽  
Chen Zhu ◽  
Mancy Tong ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Menstrual Cycle ◽  
Blood Loss ◽  
Body Mass ◽  
Odds Ratio ◽  
Normal Weight ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Menstrual Cycles ◽  
Significant Difference

Abstract Background: Irregular menstrual cycles including the length of cycles and menses, and heavy menstrual blood loss are linked to many gynaecological diseases. Obesity has been reported to be associated with irregular menstrual cycles. However, to date, most studies investigating this association are focused on adolescence or university students. Whether this association is also seen in adult women, especially women who had a history of birth has not been fully investigated. Methods: Questionnaire data were collected from 1012 women aged 17 to 53 years. Data on age, weight and height, gravida, the length of menstrual cycles and menses, and the number of pads used during menses were collected. Factors associated with menstrual cycle according to BMI categories were analysed.Results: There were no differences in the length of menstrual cycles and menses in women of different body mass index (BMI) groups. However, there was a significant difference in menstrual blood loss in women of different BMI categories. The odds ratio of having heavy menstrual blood loss in obese women was 2.28 (95% CL: 1.244, 4.193), compared to women with normal weight, while there was no difference in the odds ratio of having heavy menstrual blood loss in overweight, compared to normal weight, women. In contrast, the odds ratio of having heavy menstrual blood loss in underweight women was 0.4034 (95% CL: 0.224, 0.725), compared to women with normal weight. Conclusion: Although BMI was not correlated with the length of menstrual cycle and menses, BMI is positively associated with menstrual blood loss. Our data suggest that BMI influences menstrual blood loss in women of reproductive age and weight control is important in women’s reproductive years.

scholarly journals Migraine Associated with Menstruation An Overlooked Trigger

2021 ◽  
Vol 59 (238) ◽  
Author(s):  
Ashlesha Chaudhary
Keyword(s):  
Menstrual Cycle ◽  
Significant Role ◽  
Treatment Method ◽  
Menstrual Migraine ◽  
Menstrual Cycles ◽  
Estrogen Withdrawal ◽  
Hormonal Fluctuations

Menstrual migraine is a condition in females, where headaches are linked with menstruation and may be debilitating. Hormonal fluctuations could have a key role in migraine etiopathogenesis, as several women experience that their migraine attacks correlate with their menstrual cycle. Estrogen withdrawal appears to have a significant role in migraine associated with menstrual cycles, despite the fact that its pathophysiology is not well known. The treatment method can also vary from that used to treat nonmenstrual migraines. However, with proper identification and management of the condition, it can be bearable. This article highlights some portions of what is known about migraine, its triggers including the experience of a sufferer and aims to provide readers with a better understanding of migraine in women by understanding these aspects of the condition.

scholarly journals Sonoelastographic assessment of the normal uterus and ovaries using the Shear Wave Elastography according to different menstrual phases

2021 ◽  
Vol 3 (2) ◽  
pp. 29-32
Author(s):  
Özgür Turan ◽  
Ersen Ertekin ◽  
Oghuz Abdullayev ◽  
Behram Kuh
Keyword(s):  
Menstrual Cycle ◽  
Shear Wave ◽  
Systemic Disease ◽  
Shear Wave Elastography ◽  
Cycle Period ◽  
Menstrual Phase ◽  
Menstrual Cycles ◽  
Pelvic Ultrasonography ◽  
Significant Difference ◽  
Relationship Of

Objective: In most of the gynecological studies conducted using the Shear Wave Elastography (SWE) method in the literature, the menstrual cycle period was not taken into account. Current study, we aimed to describe the sonoelastographic features of normal myometrium and ovaries in healthy women and to define their variability during the different phases of the menstrual cycle using the SWE method. Material and methods: All cases were selected from individuals between the ages of 24-31, with regular menstrual cycles and no systemic disease. Each case was called in, 1-5th, 12-16th, 21-24th day of their menstrual cycles and was evaluated by B-mode imaging and SWE in pelvic ultrasonography. The relationship of menstrual phases with uterine and ovarian elasticity was investigated by comparing all measurements made in different menstrual phases. Results: No statistically significant difference was observed between the volume of right and left ovaries in terms (p> 0.05). There was no statistically significant difference in terms of elastography measurements obtained from the uterus, right and left ovaries for each menstrual phase according to Bonferroni Correction (p> 0.0163). Conclusion: Although there was a slight decrease in myometrial SWE measurements in the follicular phase, there was no significant difference regarding the SWE measurements of uterus and ovaries in early follicular, peri-ovulatory, and luteal menstrual stages. Further studies with a large number of participants are needed to suggest whether gynecological studies planned to be carried out with the shear wave elastography method should be planned in a specific menstrual phase.

scholarly journals Is body mass index associated with irregular menstruation: A questionnaire study?

2020 ◽  
Author(s):  
Yunhui Tang ◽  
Yan Chen ◽  
Hua Feng ◽  
Chen Zhu ◽  
Mancy Tong ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Menstrual Cycle ◽  
Blood Loss ◽  
Body Mass ◽  
Odds Ratio ◽  
Normal Weight ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Menstrual Cycles ◽  
Significant Difference

Abstract Background: Irregular menstrual cycles including the length of cycles and menses, and heavy menstrual blood loss are linked to many gynaecological diseases. Obesity has been reported to be associated with irregular menstrual cycles. However, to date, most studies investigating this association are focused on adolescence or university students. Whether this association is also seen in adult women, especially women who had a history of birth has not been fully investigated. Methods: Questionnaire data were collected from 1012 women aged 17 to 53 years. Data on age, weight and height, gravida, the length of menstrual cycles and menses, and the number of pads used during menses were collected. Factors associated with menstrual cycle according to BMI categories were analysed.Results: There were no differences in the length of menstrual cycles and menses in women of different body mass index (BMI) groups. However, there was a significant difference in menstrual blood loss in women of different BMI categories. The odds ratio of having heavy menstrual blood loss in obese women was 2.28 (95%CL: 1.244, 4.193), compared to women with normal weight, while there was no difference in the odds ratio of having heavy menstrual blood loss in overweight, compared to normal weight, women. In contrast, the odds ratio of having heavy menstrual blood loss in underweight women was 0.4034 (95%CL: 0.224, 0.725), compared to women with normal weight. Conclusion: Although BMI was not correlated with the length of menstrual cycle and menses, BMI is positively associated with menstrual blood loss. Our data suggest that BMI influences menstrual blood loss in women of reproductive age and weight control is important in women’s reproductive years.

The Relationship Between Menstruation Cycle and Exercise Participation in Korean Female College Students

2020 ◽  
Author(s):  
Sunghwun Kang ◽  
Il Bong Park ◽  
Woo Suk Chung
Keyword(s):  
Menstrual Cycle ◽  
University Students ◽  
Menstrual Cycles ◽  
Exercise Participation ◽  
Regular Menstrual Cycle ◽  
Health Consciousness ◽  
Significant Difference ◽  
Intensity Of Exercise ◽  
Intention To Exercise ◽  
The Relationship

Abstract Background: The purpose of this study was to examine how Korea female university students participate in physiological and psychological exercises according to differences in their menstrual cycles and health consciousness, exercise participation, and exercise intention. This study analyzed how these female students feel about their own health, participating in exercises, and the duration of the exercise according to the different menstrual cycles and their various patterns. Methods: The study surveyed women university students in Gangwon-do, Busan, and Ulsan metro city in Korea. A total of 464 questionnaires were analyzed using the statistical programs SPSS Win 22 and AMOS Win 22. We used cross-analysis, T-tests, one-way ANOVA analysis, and correlation analysis to analyze differences in health consciousness, intensity of exercise, and degree of intent to exercise in terms of the menstrual cycle and exercise pattern during the cycle. Results: First, there were no significant differences between menstrual pattern (regular vs. irregular) and general exercise periods during the non-menstrual period (X2 = 5.828, p < 0.212). However, the study showed that more female university students who had regular menstrual cycle were back to regular exercise right after their menstruation cycle ended, and the girls with irregular menstrual cycles did not exercise as much right after their menstruation cycle ended. Second, there were significant differences in the relationship between health consciousness (p = 0.000), amount of exercise (p = 0.002), and grade of intention to exercise (p = 0.002) according to the differences in menstrual cycles and pattern of Korean female university students. Female university students with a regular menstrual cycle showed higher health consciousness, amount of exercise, and intent to exercise than did ones with irregular menstrual cycles. Third, there was a significant difference in the relationship between health consciousness (p = 0.000), amount of exercise (p = 0.000), and intent to exercise (p = 0.000) in accordance with exercise period (did not exercise, before menstruation, after menstruation, and when not menstruating, always) of Korean female university students. In other words, female university students who exercised were higher than female university students who did not exercise.Conclusions: In this study, Korean female university students who had regular menstrual cycles exercised regularly and showed a high level of their own health consciousness, amount of exercise, and intention to exercise. Also, female university students who exercise regularly have a higher level of health consciousness, amount of exercise, and intention to exercise. This study will be valuable as a pilot study related to physiological, psychological factors, and exercise of women.

scholarly journals Influence of fixed orthodontic treatment on the menstrual cycle of adult females: A prospective longitudinal study

2015 ◽  
Vol 86 (3) ◽  
pp. 475-480 ◽  
Author(s):  
Peipei Duan ◽  
Wenwen Qu ◽  
Shujuan Zou ◽  
Yangxi Chen ◽  
Hui Lan ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Menstrual Cycle ◽  
Orthodontic Treatment ◽  
Adult Women ◽  
Prospective Longitudinal Study ◽  
Menstrual Cycles ◽  
Adult Females ◽  
Significant Difference ◽  
Accompanying Symptoms ◽  
Prospective Longitudinal

ABSTRACT Objective:  To investigate the influence of fixed orthodontic treatment on the menstrual cycle, including menstrual cycle length (MCL) and duration of menstrual bleeding (DMB), in adult female patients. Materials and Methods:  This was a prospective longitudinal study conducted in Chengdu, China. A total of 164 adult women with normal menstrual cycles were recruited in the study, with 79 patients undergoing orthodontic treatment and 85 serving as controls. Data of MCL, DMB, and accompanying symptoms were collected over six consecutive menstrual cycles in each participant. Student’s t test, Chi-square test, Moses extreme reaction test, and repeated measures analysis of variance were used for statistical analysis. Results:  The MCL of the first menstrual cycle (T1) was significantly elongated by 2.1 ± 0.5 days compared with baseline (P  =  .003, 95% CI [−3.7, −0.5]). Variability of MCL of the orthodontic group at T1 was also significantly greater (range, 15–46 days) than that of the control group (range, 24–36 days) (P &lt; .05). No significant difference in MCL was found in the subsequent five menstrual cycles (T2–T6) compared with baseline, and no significant differences in DMB or other accompanying symptoms were observed throughout the study. Conclusion:  Fixed orthodontic treatment may influence the MCL of adult females in the first month after bonding, but showed no effect on DMB or subsequent MCL through the follow-ups.

Sign in / Sign up

Export Citation Format

Share Document