HYPERTENSION FOLLOWING SUBCUTANEOUS AND INTRAPERITONEAL INJECTIONS OF POLYVINYL ALCOHOL AND THE EFFECT OF ALDOSTERONE

1967 ◽  
Vol 45 (1) ◽  
pp. 161-168 ◽  
Author(s):  
C. E. Hall ◽  
O. Hall
Keyword(s):  
Polyvinyl Alcohol ◽  
Foam Cells ◽  
Giant Cells ◽  
Considerable Time ◽  
Do So

Rats given subcutaneous or intraperitoneal injections of polyvinyl alcohol (PVA) for a month developed hypertension after discontinuance of injections. Aldosterone given for a week terminally to severely hypertensive animals neither exacerbated hypertension nor induced the eclamptic manifestations previously noted to occur after more prolonged subcutaneous PVA administration. It is concluded that eclamptic manifestations are not due to increased levels of endogenous salt-retaining steroids. Possible reasons are considered for the customary inability of rats given PVA intraperitoneally to develop hypertension during the course of injections although they readily do so thereafter.Intraperitoneal PVA administration caused the formation of medial and intimal foam cells in cardiac arteries, and an abundant display of giant cells in various organs and tissues. In contradistinction to the earlier findings in animals killed immediately after a course of injections, there was in this study, in which the rats were killed only when a considerable time had elapsed after PVA treatment, no substantial difference in the severity of hepatosplenomegaly between intraperitoneally and subcutaneously injected rats.

Heterogeneous differentiation of external cells in individual isolated early mouse inner cell masses in culture

Development ◽  
1984 ◽  
Vol 80 (1) ◽  
pp. 225-240
Author(s):  
J. Nichols ◽  
R. L. Gardner
Keyword(s):  
Mitotic Cycle ◽  
Giant Cells ◽  
Cell Number ◽  
Small Cells ◽  
External Layer ◽  
Tissue Heterogeneity ◽  
Dense Suspension ◽  
Early Mouse ◽  
Do So

Inner cell masses (ICMs) were isolated from early blastocysts by immunosurgery and incubated in a dense suspension of melanin granules for 3h after 21 h in culture. The majority of such labelled ICMs subsequently formed outgrowths in vitro in which either giant cells or small solitary cells contained melanin granules. However, a substantial minority produced outgrowths in which both types of cell were unequivocally labelled. Labelled cells appeared from the results of control experiments to have originated within the external layer of the ICM. The giant cells were indistinguishable morphologically from those formed by authentic trophectodermal tissue. The small cells were identified as belonging to the extraembryonic endodermal lineage on the basis of their distribution in host conceptuses following injection into blastocysts. These findings support the conclusion reached in previous studies that early ICM cells can engage in trophectodermal differentiation under certain conditions. In addition, by providing evidence that both trophectoderm and endoderm cells can differentiate from the outer layer of the same ICM, they argue that loss of cellular lability is not coordinated throughout this tissue. Heterogeneity in the differentiation of external cells may depend on differences in both the stage of the mitotic cycle and the number of such cycles that they have completed since fertilization. Finally, cell number in isolated early ICMs was found to increase approximately two-fold during the first 24 h of culture in the present experiments. This contrasts with the results of previous experiments in which cell number either increased more modestly or failed to do so altogether.

Juvenile xanthogranulomas with inconspicuous or absent foam cells and giant cells

1991 ◽  
Vol 24 (6) ◽  
pp. 1005-1009 ◽  
Author(s):  
Philip E. Shapiro ◽  
David N. Silvers ◽  
Ruth K. Treiber ◽  
Philip H. Cooper ◽  
Lawrence D. True ◽  
...  
Keyword(s):  
Foam Cells ◽  
Giant Cells

scholarly journals THE CELLULAR REACTIONS TO LIPOID FRACTIONS FROM ACID-FAST BACILLI

1932 ◽  
Vol 56 (6) ◽  
pp. 867-891 ◽  
Author(s):  
Kenneth C. Smithburn ◽  
Florence R. Sabin
Keyword(s):  
Life Cycle ◽  
Connective Tissue ◽  
Comparative Study ◽  
Fine Particles ◽  
Giant Cells ◽  
Epithelioid Cell ◽  
Epithelioid Cells ◽  
Acid Fast Bacilli ◽  
Tissue Cells ◽  
Do So

1. A comparative study has been made of the cellular reactions induced by phosphatides from five strains of acid-fast bacilli. Each of these reactions is characterized principally by epithelioid cells and giant cells. 2. The phosphatides are first phagocytized by young connective tissue cells or monocytes. The lipoid is then dispersed into fine particles with the formation of classical epithelioid cells. 3. A comparison has been made of the reactions induced by heat-killed and defatted tubercle bacilli with those induced by tuberculophosphatide. 4. Further studies have been made to determine whether or not the phosphatide causes sensitization to tuberculin. It does not do so. 5. The life cycle of the epithelioid cell has been observed in all its stages.

JUVENILE XANTHOGRANULOMA WITH INCONSPICUOUS FOAM CELLS AND GIANT CELLS

1995 ◽  
Vol 34 (9) ◽  
pp. 653-655 ◽  
Author(s):  
WARREN S. TANZ ◽  
Y. ALYSSA KIM ◽  
ROBERT A. SCHWARTZ ◽  
THOMAS WALTERS ◽  
CAMILA K. JANNIGER ◽  
...  
Keyword(s):  
Foam Cells ◽  
Giant Cells ◽  
Juvenile Xanthogranuloma

scholarly journals Distinguishing a Rare Variant of Lipidized Dermatofibroma from Nonlipidized Dermatofibromas in a Patient with Hypothyroidism and Alopecia Areata

2017 ◽  
Vol 9 (2) ◽  
pp. 53-56
Author(s):  
Farah Abdulla ◽  
Heather Peck ◽  
Ashley Feneran ◽  
Ashley Jenkins ◽  
Katherine Mullersman
Keyword(s):  
Alopecia Areata ◽  
Cellular Proliferation ◽  
Foam Cells ◽  
Giant Cells ◽  
Collagen Fibers ◽  
Factor Xiiia ◽  
Spindle Cells ◽  
Dermal Collagen ◽  
History Of ◽  
Biopsy Examination

Abstract Introduction. Lipidized dermatofibromas represent rare and often underrecognized variants of dermatofibromas. Histologically, dermatofibromas are composed of fibroblast-like spindle cells, foam cells, giant cells, siderophages, lymphocytes, capillaries, collagen fibers, and hyaline dermal collagen fibers. Lipidized dermatofibromas are characterized by numerous foam cells, Touton giant cells, and hyalinized wiry collagen in the stroma. Case report. We present a case of a 31-year-old woman with a history of hypothyroidism and alopecia areata, presenting with an enlarging 8 mm, firm erythematous nodule on her upper-mid back. Biopsy examination showed a cellular proliferation of spindle cells with peripheral collagen trapping and cholesterol clefts with associated foam cells and sclerosis, staining weakly positive for Factor XIIIa and negative for CD34. The diagnosis of a benign lipidized dermatofibroma was rendered. Conclusion. Lipidized dermatofibromas are rare histologic variants of dermatofibromas, biologically indolent, and should be distinguished from other cutaneous foamy histiocytic lesions, particularly xanthomas, which may alter patient management.

Xanthelasma or Xanthoma of the Fallopian Tube

2003 ◽  
Vol 127 (11) ◽  
pp. e417-e419
Author(s):  
Runjan Chetty ◽  
Isaivani Reddy ◽  
Sixto Batitang
Keyword(s):  
Fallopian Tube ◽  
Inflammatory Cell ◽  
Ultrasound Examination ◽  
Inflammatory Cells ◽  
Foam Cells ◽  
Giant Cells ◽  
Inflammatory Cell Infiltrate ◽  
Rebound Tenderness ◽  
First Case ◽  
Foamy Cytoplasm

Abstract We report a case of a 24-year-old woman who presented with abdominal pain, a tense abdomen, and rebound tenderness. A vague, ill-defined mass was palpated, and an ultrasound examination revealed a cystic lesion in the left adnexal region. At laparotomy, a slightly dilated fallopian tube was seen and excised. Light microscopy showed intact fallopian tube mucosa, with a diffuse infiltrate of foam cells in the lamina propria. There were no associated inflammatory cells. The foam cells were positive for CD68 and negative for AE1/AE3. Discontinuous areas of the epithelium also showed epithelial cells with “foamy cytoplasm.” These cells were negative for CD68 but positive for AE1/AE3. To our knowledge, this represents the first case of a fallopian tube xanthelasma that shows a resemblance to lesions encountered in the stomach. Fallopian tube xanthelasma must be distinguished from xanthogranulomatous salpingitis, which is associated with an inflammatory cell infiltrate, often including giant cells. However, this lesion may share pathogenetic similarities with xanthogranulomatous salpingitis, since both processes are mediated by inflammation.

scholarly journals THE REACTIONS BETWEEN BACTERIA AND ANIMAL TISSUES UNDER CONDITIONS OF ARTIFICIAL CULTIVATION

1916 ◽  
Vol 23 (3) ◽  
pp. 283-291 ◽  
Author(s):  
Henry Field Smyth
Keyword(s):  
Connective Tissue ◽  
Giant Cells ◽  
Heart Tissue ◽  
Splenic Tissue ◽  
Tissue Cultures ◽  
Cell Degeneration ◽  
Multinuclear Cells ◽  
Complete Cell ◽  
Made In ◽  
Do So

In plasma cultures, with or without tissue, tubercle bacilli form characteristic streptothrix-like colonies of loosely twisted skeins of threads. In plasma tissue cultures embryonal connective tissue and epithelial cells phagocytyze tubercle bacilli freely. Splenic tissue cultures from fourteen day or older embryos if inoculated with isolated bacilli will phagocytyze and prevent the development of all or nearly all bacilli present. If heavy inoculations of tubercle bacilli with many bacillary clumps are made in splenic cultures the bacilli develop more freely than in similar connective tissue cultures from heart tissue in spite of marked phagocytosis. In such cultures the first change seen is a clustering of small round cells, interpreted as lymphocytes, around bacillary clumps and colonies followed by a similar clustering of larger parenchymatous polygonal cells with one or several nuclei, interpreted as epithelioid cells, which phagocytyze any bacilli with which they may come in contact. The larger cells containing bacilli then fuse to form larger multinuclear cells and these by further fusion form typical giant cells with quiescent nuclei in characteristic groupings and bacilli in degenerated protoplasm away from the nuclear groups. Cells which have phagocytyzed bacilli may digest them or may be unable to do so, in which case the bacilli develop within the cells and eventually cause complete cell degeneration.

Some Remarks as to providing increased and Better Means for Educating the Insane of all Classes

1876 ◽  
Vol 22 (99) ◽  
pp. 416-420
Author(s):  
Joseph Lalor
Keyword(s):  
Free Expression ◽  
Special Committee ◽  
Considerable Time ◽  
The Social ◽  
The Subject ◽  
Charity Organization ◽  
Do So ◽  
Deep Interest

A Special Committee, apppointed by the Charity Organization Society, have had under their consideration for a considerable time the subject of placing Institutions for Idiots, Imbeciles, and Harmless Lunatics on the most comprehensive and satisfactory footing. The investigations of this Committee, and the report to be made by them to the Parent Society, will be likely to have much influence on the determination of many questions in which our Association has a deep interest. The Committee have evinced laudable anxiety to obtain advice and information, and to consider their subject cautiously, thoughtfully, and impartially. I think they have, in consequence, the strongest claims on the confidence and thankfulness of our Association. From a communication made by the Committee to the Social and Statistical Society of Ireland, and from being furnished, through the kindness of Dr. Hack Tuke, with copies of its agenda up to this, I happen to have become acquainted with the views of the Committee, and I propose to avail myself of the opportunity thus afforded, by making some remarks on a few of the conclusions they have arrived at. I shall, however, try to do so in a way that will not, by any means, hamper the proceedings of the Committee, or the full and free expression of their opinions; but which may conduce to a community of opinion, and a co-operation in action, or, at least, to a friendly and harmonious rivalry between the Charity Organization Society and our Association, calculated to produce most desirable results.

Some Remarks as to providing increased and Better Means for Educating the Insane of all Classes

1876 ◽  
Vol 22 (99) ◽  
pp. 416-420
Author(s):  
Joseph Lalor
Keyword(s):  
Free Expression ◽  
Special Committee ◽  
Considerable Time ◽  
The Social ◽  
The Subject ◽  
Charity Organization ◽  
Do So ◽  
Deep Interest

A Special Committee, apppointed by the Charity Organization Society, have had under their consideration for a considerable time the subject of placing Institutions for Idiots, Imbeciles, and Harmless Lunatics on the most comprehensive and satisfactory footing. The investigations of this Committee, and the report to be made by them to the Parent Society, will be likely to have much influence on the determination of many questions in which our Association has a deep interest. The Committee have evinced laudable anxiety to obtain advice and information, and to consider their subject cautiously, thoughtfully, and impartially. I think they have, in consequence, the strongest claims on the confidence and thankfulness of our Association. From a communication made by the Committee to the Social and Statistical Society of Ireland, and from being furnished, through the kindness of Dr. Hack Tuke, with copies of its agenda up to this, I happen to have become acquainted with the views of the Committee, and I propose to avail myself of the opportunity thus afforded, by making some remarks on a few of the conclusions they have arrived at. I shall, however, try to do so in a way that will not, by any means, hamper the proceedings of the Committee, or the fall and free expression of their opinions; but which may conduce to a community of opinion, and a co-operation in action, or, at least, to a friendly and harmonious rivalry between the Charity Organization Society and our Association, calculated to produce most desirable results.

Juvenile Xanthogranulomas with Inconspicuous or Absent Foam Cells and Giant Cells

1991 ◽  
Vol 13 (2) ◽  
pp. 198 ◽  
Author(s):  
P. E. Shapiro ◽  
D. N. Silvers ◽  
R. K. Treiber ◽  
R. Lattes
Keyword(s):  
Foam Cells ◽  
Giant Cells
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