ON THE RELATIONSHIP BETWEEN TESTICULAR BLOOD FLOW AND SECRETION OF TESTOSTERONE IN ANESTHETIZED DOGS STIMULATED WITH HUMAN CHORIONIC GONADOTROPHIN

1964 ◽  
Vol 42 (5) ◽  
pp. 671-677 ◽  
Author(s):  
Kristen B. Eik-Nes
Keyword(s):  
Blood Flow ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Arterial Blood Flow ◽  
Constant Infusion ◽  
Left Testis ◽  
Arterial Blood ◽  
Constant Rate ◽  
Anesthetized Dogs ◽  
The Relationship

The concentration of testosterone has been measured in spermatic vein blood from the left testis in 25 anesthetized dogs, stimulated with human chorionic gonadotrophin and infused with arterial blood via the left spermatic artery at different rates. The secretion of testosterone varied with the rate at which arterial blood was infused and at a constant infusion rate of 3.81 ml/min, animals weighing from 19 to 23 kg produced testosterone at a constant rate over 90 minutes. Infusion rates lower than this decreased the secretion of testosterone, and if arterial blood was infused at a rate of 0.76 ml/min for the first 30 minutes of experimentation, the capacity of the infused testis to secrete testosterone in the ensuing 60 minutes was impaired even in animals given large doses of human chorionic gonadotrophin via the left spermatic artery. A relationship between the arterial blood flow to the testis and its ability to secrete testosterone under the influence of human chorionic gonadotrophin is thus established.

Relationship between portal venous and hepatic arterial blood flows: spectrum of response

1990 ◽  
Vol 259 (6) ◽  
pp. G1010-G1018 ◽  
Author(s):  
T. Kawasaki ◽  
F. J. Carmichael ◽  
V. Saldivia ◽  
L. Roldan ◽  
H. Orrego
Keyword(s):  
Blood Flow ◽  
Arterial Blood Flow ◽  
Portal Vein Ligation ◽  
Artery Ligation ◽  
Blood Flows ◽  
Arterial Blood ◽  
Group A ◽  
Group B ◽  
The Relationship ◽  
Group D

The relationship between portal tributary blood flow (PBF) and hepatic arterial blood flow (HAF) was studied in awake, unrestrained rats with the radiolabeled microsphere technique. Six distinct patterns of response emerged. In group A (PBF+, HAF 0), ethanol, acetate, glucagon, prostacyclin, and a mixed diet increased PBF without a change in HAF; in group B (PBF+, HAF+), adenosine and histamine increased both PBF and HAF; in group C (PBF 0, HAF+), isoflurane and triiodothyronine did not change PBF but increased HAF; and in group D (PBF-, HAF+), halothane and vasopressin decreased PBF and increased HAF. Acute partial portal vein ligation decreased PBF (56%) and increased HAF (436%). Hypoxia (7.5% O2) decreased PBF (28%) and increased HAF (110%). In group E (PBF+, HAF-), acute hepatic artery ligation increased PBF (35%) and reduced HAF (74%), while in group F (PBF-, HAF-), thyroidectomy reduced PBF and HAF (36 and 47%, respectively). All blood flow responses were accompanied by the expected changes in both portal tributary and hepatic arterial vascular resistances. The data suggest that the portal and hepatic arterial vascular territories have regulatory mechanisms that allow for independent changes.

Relationship of pyruvate and lactate during anaerobic metabolism. V: Coronary adequacy

1961 ◽  
Vol 200 (6) ◽  
pp. 1169-1176 ◽  
Author(s):  
William E. Huckabee
Keyword(s):  
Blood Flow ◽  
Coronary Flow ◽  
Cardiac Tissue ◽  
Anaerobic Metabolism ◽  
Constant Ratio ◽  
Blood Concentrations ◽  
Arterial Blood ◽  
Anesthetized Dogs ◽  
Relationship Of ◽  
The Relationship

Veno-arterial differences of pyruvate and lactate across the myocardium in chloralose-anesthetized dogs were very variable; in any one animal they changed continually with time despite constant blood flow and arterial blood concentrations. There was a systematic tendency of v-a lactate to vary with v-a pyruvate, as expressed in the calculated "Δ excess lactate," which remained nearly constant (or, if blood flow changed, bore a constant ratio to (a-v)O2). No change in Δ excess lactate from control values occurred in nonhypoxic experiments despite marked changes in v-a differences, arterial blood composition, and coronary flow. Cardiac Δ excess lactate became positive in most animals breathing 10% O2 in N2; output of excess lactate was also observed in all those in which moderate muscular exercise was induced. This anaerobic metabolism, or change in the relationship between pyruvate and lactate exchanges, was interpreted as an indication that O2 delivery response was not adequate to meet cardiac tissue requirements during such mild stresses when judged by the standards of adequacy of the basal state.

scholarly journals Continuous Measurement of Changes in Internal Carotid and Vertebral Arterial Blood Flow with Chronically Implanted Ultrasonic Doppler Probes in Anesthetized and Conscious Rabbits

1996 ◽  
Vol 16 (5) ◽  
pp. 1058-1067 ◽  
Author(s):  
Ying-Hui Yu ◽  
B-S Zhu ◽  
W. W. Blessing
Keyword(s):  
Blood Flow ◽  
Internal Carotid ◽  
Arterial Blood Flow ◽  
Noninvasive Measurements ◽  
Sagittal Sinus ◽  
Doppler Probe ◽  
Arterial Blood ◽  
Arterial Inflow ◽  
Conscious Rabbits ◽  
The Relationship

Chronically implanted ultrasonic Doppler flowmeters were used to obtain simultaneously recorded flow velocity signals from internal carotid and vertebral arteries, and the sagittal sinus, in rabbits. All three signals increased to 144 ± 7–215 ± 35% of baseline during hypercapnia (arterial Pco2 55 mmHg) in both anesthetized and conscious animals. During the period of change in inspired CO2, the relationship between simultaneously recorded mean internal carotid and mean sagittal sinus signals was linear, with the correlation ranging from 0.83 to 0.96. Since forebrain arterial inflow must approximate forebrain venous outflow, the high correlation between internal carotid and sagittal sinus signals indicates that these measures provide reliable and valid indices of cerebral blood flow (CBF). Vertebral and internal carotid angiography confirmed the location of Doppler probe. Chronically implanted ultrasonic Doppler flowmeters can, thus, provide continuous noninvasive measurements of cerebral arterial flow in both anesthetized and conscious rabbits.

scholarly journals Relationships of changes in B-mode echotexture and colour-Doppler signals in the wall of the preovulatory follicle to changes in systemic oestradiol concentrations and the effects of human chorionic gonadotrophin in mares

Reproduction ◽  
2006 ◽  
Vol 131 (4) ◽  
pp. 699-709 ◽  
Author(s):  
E L Gastal ◽  
M O Gastal ◽  
O J Ginther
Keyword(s):  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Post Treatment ◽  
Arterial Blood Flow ◽  
Preovulatory Follicle ◽  
Colour Doppler ◽  
Arterial Blood ◽  
Grey Scale ◽  
Doppler Signals ◽  
Negative Effect

A duplex grey-scale and colour-Doppler ultrasound instrument was used to study the changes in the wall of the preovulatory follicle in mares. When the follicle reached ≥35 mm (hour 0), mares were randomized into control (n= 16) and human chorionic gonadotropin (hCG)-treated (n= 16) groups. The hCG treatment was given at hour 0. Scanning was done every 12 h until hour 36, every hour between hours 36 and 48, and every 12 h thereafter until ovulation. Blood was sampled every 12 h for oestradiol assay. During the period 0–24 h post-treatment, oestradiol concentrations decreased in the hCG group and increased in the controls (significant interaction). During the period 0–36 h post-treatment, thickness and echogenicity of the granulosa increased in the hCG group but not in the controls. During the period 36 to 12 h before ovulation, granulosa and colour-Doppler end-points increased in the control and hCG groups (hour effects), while oestradiol was decreasing in both groups. The prominence and percentage of follicle circumference with an anechoic band peripheral to the granulosa and colour-Doppler signals in the follicle wall, indicating arterial blood flow, decreased during the period 4 to 1 h before ovulation (hour effects). Results indicated that the ultrasonographic changes of the wall of the preovulatory follicle were not associated temporally with changes in oestradiol concentrations and prominence of an anechoic band, and colour-Doppler signals decreased during the few hours before ovulation. The hypothesis that the latter portion of the ovulatory LH surge has a negative effect on systemic oestradiol was supported by the immediate decrease in oestradiol concentrations when hCG was injected.

scholarly journals An Exploratory Study on the Relationship between Brachial Arterial Blood Flow and Cardiac Output

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Sixiang Jia ◽  
Yiteng Wu ◽  
Wei Wang ◽  
Wenting Lin ◽  
Yiwen Chen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Brachial Artery ◽  
Theoretical Basis ◽  
Arterial Blood Flow ◽  
Artery Blood Flow ◽  
Korotkoff Sound ◽  
Arterial Blood ◽  
The Mean ◽  
The Relationship

Background. We have obtained prospective clinical outcomes using the brachial artery largely, such as Korotkoff sound and vasomotor function measurement by ultrasound guidance to predict the prognosis of cardiovascular diseases. Very few reports on the quantitative measurement of the relationship between the brachial artery blood flow and cardiac output have been reported. Purpose. (1) To investigate whether the quantitative relationship between the brachial artery blood flow and cardiac output existed. (2) To provide a theoretical basis for taking advantage of artificial intelligence (AI) using Korotkoff sound analogously as far as possible to predict the cardiac output. Methods. A total of 586 patients who underwent cardiac color ultrasound in our center from 2021.3 to 2021.7 were included for analyses. The vascular parameters of the right upper limb brachial artery (such as the Diameter, Area, Blood Velocity, and Flow) were measured immediately after the cardiac color ultrasound, and some basic clinical parameters (Age, Sex, BMI, and Disease) were recorded subsequently. Ultimately, the Mann–Whitney and independent sample T-test were used to analyze the data. Results. (1) The mean Rate of the brachial arterial blood flow to cardiac output was 1.23%, and the mean 95% CI was (1.18%, 1.29%), indicating that the value was mainly concentrated in the current value interval. The indicator demonstrates that there is no significant difference currently among the patients with hypertension, coronary heart disease, and cardiac dysfunction. (2) The brachial artery wall diameter (Dist) is significantly thicker in patients with coronary heart disease and hypertension compared to patients with other cardiovascular diseases. (3) Cardiac output augments remarkably in patients with hypertension. Conclusion. Our study suggests that the Rate (brachial artery blood flow/cardiac output) is a constant of 1.23% approximately. It provides a theoretical basis for the subsequent application of the artificial intelligence (AI) method to predict heart function using Korotkoff sound, cope with large computational amounts, and improve computational speed. It is also indirectly proved that hypertension can lead to a change in peripheral vascular hyperplasia and increase cardiac output.

Hepatic effect of insulin in unanesthetized normal, diabetic, and adrenalectomized dogs

1961 ◽  
Vol 201 (5) ◽  
pp. 804-810 ◽  
Author(s):  
William C. Shoemaker ◽  
Peter J. Carruthers ◽  
Ina C. Powers ◽  
Howard M. Yanof
Keyword(s):  
Blood Flow ◽  
Femoral Vein ◽  
Vena Cava ◽  
Arterial Blood Flow ◽  
Constant Infusion ◽  
Hepatic Glycogen ◽  
Arterial Blood ◽  
Total Hepatic Blood Flow ◽  
Free Glucose ◽  
Glucose Output

Measurement of arterial, portal, and hepatic venous plasma glucose concentrations were made in unanesthetized dogs whose hepatic vessels were previously catheterized. Total hepatic blood flow was measured by a modified Bromsulphalein method and hepatic arterial blood flow by a trapezoidal wave electromagnetic blood flowmeter. Serial biopsies of the liver were obtained, also under unanesthetized conditions, for measurement of glycogen and free glucose. Various doses of glucagon-free insulin were given by a single, rapid, intravenous injection or by a constant infusion directly into the liver via portal vein and via femoral vein or vena cava. Insulin was administered in normal, in adrenalectomized, in depancreatized, and in depancreatized-adrenalectomized dogs. Under each of the conditions observed insulin produced no decrease in the hepatic glucose output. Moreover, no increased hepatic glycogen or free glucose concentrations were found in hepatic biopsies after insulin administration.

Environmental stresses and femoral arterial blood flow

1964 ◽  
Vol 19 (3) ◽  
pp. 472-478 ◽  
Author(s):  
D. J. Boon ◽  
S. F. Marotta
Keyword(s):  
Blood Flow ◽  
Room Temperature ◽  
Ground Level ◽  
Arterial Blood Flow ◽  
Hypoxic Exposure ◽  
Arterial Blood ◽  
Significant Depression ◽  
Anesthetized Dogs ◽  
Second Period ◽  
Increased Blood Flow

Femoral arterial blood flow and related cardiopulmonary parameters were ascertained in 95 anesthetized dogs during exposure to heat, cold, altitude, hypoxia at two different times, and various combinations of these environments. Cold (1 C) and decompression (17,300 ft) without hypoxia at room temperature (24 C) each depressed arterial blood flow significantly the same amount, while the combination of decompression and cold caused a significant depression in flow less than either acting alone. Heat (38 C) alone produced slight increases in arterial pressure and heart rate; however, heat in combination with altitude depressed the flow less than did altitude alone. Hypoxia (Po2 75 mm Hg), whether from decompression or breathing 10% O2 at ground level, increased blood flow while depressing femoral vascular resistance in all animals in cold, hot, or room temperatures. The greatest hypoxic increases in blood flow were noted immediately after decompression both at 24 and 38 C, while the smallest increase was noted with hypoxic exposure during the second period at a cold, simulated altitude. circulation and stress Submitted on June 19, 1963

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