ABSENCE OF EFFECT OF BOVINE GROWTH HORMONE ON BLOOD SUGAR OF HOUSSAY DOGS

1964 ◽  
Vol 42 (3) ◽  
pp. 299-301 ◽  
Author(s):  
Anna Sirek ◽  
Karl Schoeffling ◽  
Monica Webster ◽  
Otakar V. Sirek
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Blood Sugar ◽  
Intravenous Injection ◽  
Hypoglycemic Activity ◽  
Biologically Active ◽  
Hypoglycemic Effect ◽  
Bovine Growth Hormone ◽  
Exogenous Insulin ◽  
Single Intravenous Injection

A highly purified growth hormone preparation (Wilhelmi) was tested for its hypoglycemic activity in four fasting, hypophysectomized–depancreatized dogs (Houssay dogs) maintained without exogenous insulin for 2–4 weeks. A single intravenous injection of growth hormone, 5 mg per kg body weight, had no effect on blood sugar over a period of 6 hours. It was concluded that highly purified growth hormone has no hypoglycemic effect in the absence of biologically active insulin.

RATE OF DISAPPEARANCE OF GROWTH HORMONE FROM THE PLASMA OF RATS AFTER A SINGLE INTRAVENOUS INJECTION

1955 ◽  
Vol 19 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Carl A. Gemzell ◽  
Frank Heijkenskjöld ◽  
Lars Ström
Keyword(s):  
Growth Hormone ◽  
Intravenous Injection ◽  
Single Intravenous Injection

Stimulation of food intake and weight gain in mature female rats by bovine prolactin and bovine growth hormone

1993 ◽  
Vol 264 (6) ◽  
pp. E986-E992 ◽  
Author(s):  
J. C. Byatt ◽  
N. R. Staten ◽  
W. J. Salsgiver ◽  
J. G. Kostelc ◽  
R. J. Collier
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Weight Gain ◽  
Food Intake ◽  
Body Weight Gain ◽  
Mature Female ◽  
Female Rats ◽  
Bovine Growth Hormone ◽  
Female Rat ◽  
Moisture Percentage

Recombinant bovine prolactin (rbPRL) or bovine growth hormone (rbGH) was administered to mature female rats (10/treatment group) by daily subcutaneous injection for 10 days. Doses ranged from 7 to 5,000 micrograms/day (0.03-24 mg/kg body wt). Both rbPRL and rbGH increased body weight gain and food intake, but these parameters were increased at lower doses of rbPRL (7-63 micrograms/day) than rbGH (> 190 micrograms/day). Weight gain and food intake were maximally stimulated by 190 micrograms/day rbPRL, whereas maximal increased weight gain was obtained with the highest dose of rbGH (5,000 micrograms/day). Total carcass protein was increased by both hormones; however, protein as a percentage of body weight was unchanged. Similarly, neither rbPRL nor rbGH changed the percentage of carcass moisture. Percentage of body fat was increased by rbPRL but was decreased by rbGH. Weight of the gastrointestinal tract and kidneys was increased by both hormones, but increases were in proportion to body weight gain. These data confirm that ungulate prolactin is a hyperphagic agent in the female rat. In addition, they suggest that, while prolactin stimulates growth in mature female rats, this growth is probably not via a somatogenic mechanism.

Hypoglycemic Action of Sulfonylureas in Patients with Diabetes Mellitus

PEDIATRICS ◽  
1956 ◽  
Vol 18 (1) ◽  
pp. 38-38
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
Blood Sugar ◽  
Hypoglycemic Effect ◽  
Childhood And Adolescence ◽  
Exogenous Insulin ◽  
Diabetes In Childhood ◽  
Patients With Diabetes ◽  
Mild Diabetes ◽  
Hypoglycemic Action

Recent reports from Germany have stimulated renewed interest in an action of certain sulfonamide compounds on the blood sugar in diabetes mellitus. A class of sulfonamide compounds termed sulfonylureas have been shown to have a hypoglycemic effect and to eliminate the need for exogenous insulin in many adults with diabetes mellitus. This effect is believed to be due to an action of sulfonylureas as inhibitors of an enzyme responsible for the destruction of insulin (insulinase). Sulfonylureas have been most effective in adults with mild diabetes acquired late in life. Diabetes in childhood and adolescence, or in those in whom it has persisted for many years, have shown little or no response to the administration of sulfonylureas. The usefulness of these compounds in the treatment of patients with diabetes mellitus has not been determined and must be ascertained by careful clinical trials.

Bovine growth hormone fragment (1–133) has in-vitro somatomedin-like activity

1983 ◽  
Vol 96 (2) ◽  
pp. 195-199 ◽  
Author(s):  
J. P. Liberti ◽  
L. A. Durham
Keyword(s):  
Growth Hormone ◽  
Amino Acid ◽  
Costal Cartilage ◽  
Peptide Bond ◽  
Biologically Active ◽  
The Other ◽  
Bovine Growth Hormone ◽  
Amino Acid Residues ◽  
In Vitro Uptake

Thrombin digestion of bovine growth hormone (1–191) resulted in cleavage of the peptide bond between amino acid residues 133 and 134. Native growth hormone and purified peptides (1–133) and (134–191) were assayed for somatomedin-like activity. Peptide (1–133), ranging in concentration from 0·15–15 nmol/l, stimulated in-vitro uptake of [3H]thymidine by rat costal cartilage. None of the other peptides was biologically active.

scholarly journals The In vivo Effects of Caffeine on the Hypoglycemic Activity of Gliclazide and Metformin in Healthy Rats

1970 ◽  
Vol 8 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Mohammad Mohiuddin ◽  
Md Shah Amran ◽  
Md Amjad Hossain
Keyword(s):  
Body Weight ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Hypoglycemic Activity ◽  
In Vivo Study ◽  
Sugar Levels ◽  
Two Stages ◽  
Metformin Hcl

An in vivo study has been conducted to observe the effects of caffeine on the hypoglycemic activity ofgliclazide and metformin HCI in rats. For this, healthy rats weighing about 250±25 g were used and the blood sugarlevels were measured after administration of a drug alone and in combination. Diabetes was induced in rats byadministration of alloxan at a dose of 40 mg/kg body weight. Drugs were administered in rats and were observed forfour weeks. The blood sugar levels were estimated in two stages; firstly, after two week and secondly, after four weekof administration of drug. It was found that the hypoglycemic activities of both gliclazide and metformin HCl werepotentiated by concurrent application of caffeine and either of the drugs, but the extent of potentiation was more incase of metformin HCI as evident from the blood sugar level of rats.Key words: Caffeine; Gliclazide; Metformin; Diabetes; Alloxan; Blood sugar; Rats.DOI: 10.3329/dujps.v8i1.5335Dhaka Univ. J. Pharm. Sci. 8(1): 47-51, 2009 (June)

Biologically Active Cyanogen Bromide Fragments of Bovine Growth Hormone

Endocrinology ◽  
1970 ◽  
Vol 86 (2) ◽  
pp. 416-419 ◽  
Author(s):  
DAVID F. NUTTING ◽  
JACK L. KOSTYO ◽  
H. MAURICE GOODMAN ◽  
ROBERT E. FELLOWS
Keyword(s):  
Growth Hormone ◽  
Cyanogen Bromide ◽  
Biologically Active ◽  
Bovine Growth Hormone

EFFECT OF GROWTH HORMONE AND OF AN ANABOLIC STEROID ON EXCRETION OF HYDROXYPROLINE IN THE URINE OF RATS

1965 ◽  
Vol 50 (3) ◽  
pp. 321-328 ◽  
Author(s):  
K. Kowalewski
Keyword(s):  
Growth Hormone ◽  
Body Weight ◽  
Food Intake ◽  
Urinary Excretion ◽  
Anabolic Steroid ◽  
Collagen Metabolism ◽  
Bovine Growth Hormone ◽  
Urinary Hydroxyproline ◽  
Body Weights ◽  
Stimulation Of

ABSTRACT A bovine growth hormone and an anabolic steroid, methandrostenolone, were tested for their ability to stimulate collagen metabolism in rats. Urinary excretion of hydroxyproline, considered as an index of collagen metabolism, was determined prior to, during and after the treatment of animals with these hormones. Food intake and body weights were recorded daily in treated rats and in untreated controls. A significant increase in body weight was observed in the treated rats as compared with the controls. Both hormones significantly stimulated the excretion of urinary hydroxyproline in rats. It is assumed that both hormones affect the excretion of hydroxyproline through its action on metabolically active soluble collagen, and through its stimulation of the turnover of mature collagen.

scholarly journals Amino Acid Sequence of a Biologically Active Fragment of Bovine Growth Hormone

1972 ◽  
Vol 247 (12) ◽  
pp. 3874-3880
Author(s):  
Nobuyuki Yamasaki ◽  
Kenji Kangawa ◽  
Shigeru Kobayashi ◽  
Motosuke Kikutani ◽  
Martin Sonenberg
Keyword(s):  
Growth Hormone ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Biologically Active ◽  
Bovine Growth Hormone ◽  
Active Fragment
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