GLUCOSE CONSUMPTION BY THE PERFUSED, ISOLATED RAT LIVER

1963 ◽  
Vol 41 (1) ◽  
pp. 1611-1620 ◽  
Author(s):  
Ellen R. Gordon ◽  
Audrey Camire

It is shown that the perfusion of an isolated liver is a suitable and useful technique for distinguishing and investigating liver function per se. Steady state conditions were used to determine net glucose consumption by the liver. The results indicate a linear relation exists between blood glucose level and net glucose consumption by the isolated, perfused liver. Net glucose consumption was achieved at blood glucose levels as low as 100 mg/100 ml.

1963 ◽  
Vol 41 (7) ◽  
pp. 1611-1620 ◽  
Author(s):  
Ellen R. Gordon ◽  
Audrey Camire

It is shown that the perfusion of an isolated liver is a suitable and useful technique for distinguishing and investigating liver function per se. Steady state conditions were used to determine net glucose consumption by the liver. The results indicate a linear relation exists between blood glucose level and net glucose consumption by the isolated, perfused liver. Net glucose consumption was achieved at blood glucose levels as low as 100 mg/100 ml.


2009 ◽  
Vol 29 (5) ◽  
pp. 1059-1067 ◽  
Author(s):  
Joel T Dunn ◽  
Karen Anthony ◽  
Stephanie A Amiel ◽  
Paul K Marsden

Positron emission tomography (PET) using the tracer [18F]-fluorodeoxyglucose (FDG) is commonly used for measuring metabolic rate of glucose ( MRglc) in the human brain. Conventional PET methods (e.g., the Patlak method) for quantifying MRglc assume the tissue transport and phosphorylation mechanisms to be in steady state during FDG uptake. As FDG and glucose use the same transporters and phosphorylation enzymes, changing blood glucose levels can change the rates of FDG transport and phosphorylation. Compartmental models were used to simulate the effect of rising arterial glucose, from normal to hyperglycemic levels on FDG uptake for a typical PET protocol. The subsequent errors on the values of MRglc calculated using the Patlak method were investigated, and a correction scheme based on measured arterial glucose concentration ( Gp) was evaluated. Typically, with a 40% rise in Gp over the duration of the PET study, the true MRglc varied by only 1%; however, the Patlak method overestimated MRglc by 15%. The application of the correction reduced this error to −2%. In general, the application of the correction resulted in values of MRglc consistently significantly closer to the true steady state calculation of MRglc independently of changes to the parameters defining the model.


1965 ◽  
Vol 43 (4) ◽  
pp. 617-626 ◽  
Author(s):  
Ellen R. Gordon

Several factors have been found to influence the ability of the isolated rat liver to achieve and maintain a steady-state condition when receiving glucose at a constant rate. The net glucose consumed could be altered by starving the experimental animal for 72 hours, by changes in the blood of donor rats produced by starvation, by lowering of the pH of the perfusate, and by injury to the liver itself. In cases in which the net glucose consumption by the liver was lowered by starvation of the donor rats for 24 hours, the addition of insulin to the perfusate doubled the net consumption of glucose. These experiments demonstrate that insulin has an effect on the net consumption of glucose by the liver.


Arkus ◽  
2021 ◽  
Vol 7 (2) ◽  
pp. 169-175
Author(s):  
Rara Inggarsih

Some Muslims have used cupping therapy and occupies a popular position among other alternative therapeutic methods. Modern medical research evidence also confirms the benefits of the therapy recommended by the Prophet. Many medical experts know the efficacy of cupping therapy in treating disease. According to the International Diabetes Federation (IDF), in 2013, Indonesia was ranked seventh with diabetes. Cupping therapy plays a role in stimulating blood circulation in the muscles, thereby increasing the metabolism of nutrients and glucose consumption by the muscles. The increased sensitivity of insulin receptors was helping to reduce blood glucose levels. This effect is like the effect of exercise and physical activity on blood glucose levels. This study aims to determine the effect of cupping therapy on blood glucose levels.


2006 ◽  
Vol 31 (03) ◽  
Author(s):  
H Hager ◽  
E Giorni ◽  
A Felli ◽  
B Mora ◽  
M Hiesmayr ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2167-PUB
Author(s):  
KOHEI SURUGA ◽  
TSUYOSHI TOMITA ◽  
MASAKAZU KOBAYASHI ◽  
TADAHIKO MITSUI ◽  
KAZUNARI KADOKURA

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 776-P
Author(s):  
RACHEL BRANDT ◽  
MINSUN PARK ◽  
LAURIE T. QUINN ◽  
MINSEUNG CHU ◽  
YOUNGKWAN SONG ◽  
...  

Author(s):  
Hariyadi DM ◽  
Athiyah U ◽  
Hendradi E ◽  
Rosita N ◽  
Erawati T ◽  
...  

The prevention of Diabetic Mellitus (DM) and its complications is the main aim of this study, in addition to the training of lotion foot care application and the development of small scale industry. The research team delivered knowledge in the form of training on Diabetic Mellitus, healthy food, treatment and prevention of complications, and small-scale production of cosmetic products. The aim of this study was to determine the correlation between training on diabetic and lotion foot care application as preventive measures against diabetic complications on the patient's blood glucose levels in the community of residents in Banyuurip Jaya, Surabaya. It was expected from this training that the knowledge of the residents increases and people living with diabetic undergo lifestyle changes and therefore blood sugar levels can be controlled. The parameters measured in this research were blood glucose levels, the anti diabetic drug types consumed, and compliance on diabetics. This study used the data taken from 60 patients with DM over a period of one month. Questionnaires and log books was used to retrieve data and changes in blood glucose levels in diabetic patients. The results showed the demographic data of patients with type 2 diabetic of 85% female and 15% male, with the range of patients aged of 61-70 years of 46.67% and had history of diabetic (90%). The history of drugs consumed by respondents was anti diabetic drugs such as metformin (40%), glimepiride (33.37%) and insulin (6.67%). In addition, the increased knowledge of DM patients after being given the training compared to before training was shown in several questions in the questionnaire. A statistical analysis using t-test analyzed a correlation between training provided in order to enhance understanding of the patient, as well as correlation with blood glucose levels. A paired T-test showed that there was a relationship between the knowledge of trainees before and after training (p less than 0.05). An interesting result was that there was no relationship between blood glucose levels before and after training provided (p> 0.05).


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