EFFECTS OF ANGIOTENSIN INFUSIONS ON URINARY EXCRETION OF COMPOUND III AND SUBSTANCES OTHER THAN ALDOSTERONE

1962 ◽  
Vol 40 (1) ◽  
pp. 727-738 ◽  
Author(s):  
Wojciech Nowaczynski ◽  
Erich Koiw ◽  
Pierre Biron ◽  
Michel Chrétien ◽  
Jacques Genest
Keyword(s):  
Angiotensin Ii ◽  
Urinary Excretion ◽  
Ultraviolet Light ◽  
Intravenous Infusions ◽  
Human Volunteers

Intravenous infusions of synthetic angiotensin II in human volunteers resulted in the increase of the urinary excretion of at least three ultraviolet light absorbing substances referred to as compounds III, IX, and X. This was concomitant with the increase of the urinary aldosterone excretion.Compound III has been partially described before; this is extended. A brief characterization of compounds IX and X is included (see Appendix).

EFFECTS OF ANGIOTENSIN INFUSIONS ON URINARY EXCRETION OF COMPOUND III AND SUBSTANCES OTHER THAN ALDOSTERONE

1962 ◽  
Vol 40 (6) ◽  
pp. 727-738 ◽  
Author(s):  
Wojciech Nowaczynski ◽  
Erich Koiw ◽  
Pierre Biron ◽  
Michel Chrétien ◽  
Jacques Genest
Keyword(s):  
Angiotensin Ii ◽  
Urinary Excretion ◽  
Ultraviolet Light ◽  
Intravenous Infusions ◽  
Human Volunteers

Intravenous infusions of synthetic angiotensin II in human volunteers resulted in the increase of the urinary excretion of at least three ultraviolet light absorbing substances referred to as compounds III, IX, and X. This was concomitant with the increase of the urinary aldosterone excretion.Compound III has been partially described before; this is extended. A brief characterization of compounds IX and X is included (see Appendix).

Preparation and Characterization of NH2-Terminal Fibrinogen Bβ Fragments from N-DSK of Human Fibrinogen

1984 ◽  
Vol 51 (01) ◽  
pp. 016-021 ◽  
Author(s):  
S Birken ◽  
G Agosto ◽  
B Lahiri ◽  
R Canfield
Keyword(s):  
High Performance ◽  
Gel Filtration ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Reverse Phase ◽  
Human Fibrinogen ◽  
Human Volunteers ◽  
Cnbr Cleavage ◽  
Two Peaks

SummaryIn order to investigate the early release of NH2-terminal plasmic fragments from the Bβ chain of fibrinogen, substantial quantities of Bβ 1-42 and Bβ 1-21 are required as immunogens, as radioimmunoassay standards and for infusion into human volunteers to determine the half-lives of these peptides. Towards this end methods that employ selective proteolytic cleavage of these fragments from fibrinogen have been developed. Both the N-DSK fragment, produced by CNBr cleavage of fibrinogen, and Bβ 1-118 were employed as substrates for plasmin with the finding of higher yields from N-DSK. Bβ 1-42 and Bβ 1-21 were purified by gel filtration and ion-exchange chromatography on SP-Sephadex using volatile buffers. When the purified preparation of Bβ 1-42 was chromatographed on reverse-phase high performance liquid chromatography, two peaks of identical amino acid composition were separated, presumably due either to pyroglutamate or to amide differences.

Characterization of angiotensin II binding sites in African Green monkey uterus

Life Sciences ◽  
1985 ◽  
Vol 36 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Ernest P. Petersen ◽  
John W. Wright ◽  
Joseph W. Harding
Keyword(s):  
Angiotensin Ii ◽  
Binding Sites ◽  
African Green Monkey ◽  
Green Monkey

Evaluation of the Effect of Ultraviolet Light Excitation during Characterization of Silicon Carbide Epitaxial Layers

2018 ◽  
Vol 924 ◽  
pp. 261-264
Author(s):  
Hrishikesh Das ◽  
Swapna Sunkari ◽  
Oener Akdik ◽  
Andrei Konstantinov ◽  
Krister Gumaelius ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Ultraviolet Light ◽  
Defect Detection ◽  
Uv Light ◽  
Surface Treatments ◽  
Uv Laser ◽  
Original State ◽  
Optimal Surface ◽  
Light Excitation

The scanning of Silicon Carbide (SiC) epitaxy wafers for defects by ultraviolet (UV) laser or lamps is widely prevalent. In this work, we document the effects of UV light excitation on the SiC epitaxy material. An increase in background photoluminescence (PL) is observed after repeated scans. The effect of this increase on defect detection is shown. Optimal surface treatments to recover the material back to the original state are demonstrated. Further, some surface treatments are proposed which reduce the effect of the UV light excitation and prevent to a large extent the rise in background PL.

Characterization of the postocclusive response of renal blood flow in the cat

1978 ◽  
Vol 235 (4) ◽  
pp. F286-F290 ◽  
Author(s):  
W. S. Spielman ◽  
H. Osswald
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Renal Artery ◽  
Renal Blood Flow ◽  
Artery Occlusion ◽  
Renal Nerves ◽  
Vasoconstrictor Response ◽  
Renal Artery Occlusion ◽  
Chronic Denervation

In contrast to the postocclusive hyperemia of brain, heart, and skeletal muscle, the hemodynamic response of the kidney following renal artery occlusion is highly variable in that both hyperemia and ischemia have been reported. The present study evaluates the factors influencing the renal response to complete renal artery occlusion (5-60 s) in the anesthetized cat. Marked postocclusive vasoconstriction could only be domonstrated in meclofenamate-treated (10 mg/kg) cats. The delta% renal blood flow (RBF) (30-s occlusion) was 16 +/- 4 in controls and 54 +/- 4 after meclofenamate (n= 10; P less than 0.001). Chronic denervation of the kidney, alpha-adrenergic receptor blockade, or infusion of [Sar1, Ile8]angiotensin II(2 microgram/min per kg) did not affect the postocclusive reduction of RBF, indicating that the vasoconstriction was independent of renal nerves, catecholamines, and circulating angiotesin II. Adenosine injected into the renal artery of five cats caused a dose-dependent transient fall of RBF. A dose of 100 nmol adenosine reduced RBF by 44 +/- 6% whereas after meclofenamate only 1 nmol produced the same degree of vasoconstriction. In summary, this study demonstrates a marked potentiation of the postocclusive vasoconstrictor response and the vasoconstrictive action of adenosine by meclofenamate in the anesthetized animal. No evidence was obtained to support a role for the sympathetic nervous system or circulating angiotensin II in mediating the postocclusive vasoconstriction.

scholarly journals The Pharmacological Characterization of FK 739, a New Angiotensin II-Receptor Antagonist

1993 ◽  
Vol 63 (3) ◽  
pp. 335-344 ◽  
Author(s):  
Kaori Hamada ◽  
Yoshimitsu Nakajima ◽  
Hisataka Nirei ◽  
Chie Nakajima ◽  
Akira Nagashima ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Angiotensin Ii Receptor ◽  
Angiotensin Ii Receptor Antagonist ◽  
Pharmacological Characterization
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