CREATINE KINASE IN NORMAL AND DYSTROPHIC MOUSE MUSCLE

1962 ◽  
Vol 40 (1) ◽  
pp. 443-447
Author(s):  
C. Nichol ◽  
P. L. McGeer ◽  
J. R. Miller
Keyword(s):  
Creatine Kinase ◽  
Muscular Dystrophy ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mouse Muscle ◽  
Dystrophic Mouse ◽  
Leg Muscle ◽  
The Difference ◽  
Dystrophic Mice

The hind leg muscle of normal mice and mice with hereditary muscular dystrophy was taken for individual analyses of the creatine-phosphorylating enzyme, creatine kinase. Creatine kinase activity was always found to be higher in the muscle of normal mice than in that of dystrophic mice, and the values in each group decreased with increasing age of the mice. The difference was greatest in mice of 2 weeks of age, and in the light of these findings some suggestions are made about the pathogenesis of muscular dystrophy.

CREATINE KINASE IN NORMAL AND DYSTROPHIC MOUSE MUSCLE

1962 ◽  
Vol 40 (4) ◽  
pp. 443-447 ◽  
Author(s):  
C. Nichol ◽  
P. L. McGeer ◽  
J. R. Miller
Keyword(s):  
Creatine Kinase ◽  
Muscular Dystrophy ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mouse Muscle ◽  
Dystrophic Mouse ◽  
Leg Muscle ◽  
The Difference ◽  
Dystrophic Mice

The hind leg muscle of normal mice and mice with hereditary muscular dystrophy was taken for individual analyses of the creatine-phosphorylating enzyme, creatine kinase. Creatine kinase activity was always found to be higher in the muscle of normal mice than in that of dystrophic mice, and the values in each group decreased with increasing age of the mice. The difference was greatest in mice of 2 weeks of age, and in the light of these findings some suggestions are made about the pathogenesis of muscular dystrophy.

Serum Creatine Kinase Activity and Delayed Onset Muscle Soreness in Prepubescent Children: A Preliminary Study

1989 ◽  
Vol 1 (4) ◽  
pp. 351-359 ◽  
Author(s):  
Lauri M. Webber ◽  
William C. Byrnes ◽  
Thomas W. Rowland ◽  
Vicky L. Foster
Keyword(s):  
Creatine Kinase ◽  
Muscle Soreness ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Serum Creatine Kinase ◽  
Delayed Onset Muscle Soreness ◽  
Control Group ◽  
Delayed Onset ◽  
Single Bout ◽  
The Difference

Although delayed onset muscle soreness and increased serum creatine kinase activity (SCKA) following unaccustomed exercise is common in adults, little is known concerning these responses in children. The perception of muscle soreness and SCKA in children (n = 16) (M age = 10.4±.30 yr) was compared to a control group of adults (n = 15) (M age = 27.1±.87 yr) following a single bout of downhill running (30 min − 10% grade). Preexercise SCKA was not significantly different between the children (91.7±8.5 μmol•L−1•min−1) and the adults (77.1±5.9 μmol•L−1•min−1). The difference in SCKA (pre to 24 hours post) was significantly less (p<.01) for the children (68.6±16.2 μmol•L−1•min−1) than for the adults (188.7±36.8 μmol•L−1•min−1). When the groups were adjusted for weight differences, SCKA was not significantly different between the adults and the children. Regardless of age, males demonstrated a significantly greater increase in SCKA postexercise when compared to females. Soreness ratings (verbally anchored scale from 1 to 10) 24 hours following the downhill run were not significantly different between the children (3.8±.6) and the adults (4.5±.7). Following an eccentrically biased exercise task, children exhibited less of a SCKA response compared to adults that is related to body weight.

SERUM CREATINE KINASE ACTIVITY AND CARRIER STATUS FOR DUCHENNE MUSCULAR DYSTROPHY

The Lancet ◽  
1979 ◽  
Vol 314 (8156-8157) ◽  
pp. 1370 ◽  
Author(s):  
D.G. Bullock ◽  
F.M. Mcsweeney ◽  
T.P. Whitehead ◽  
J.H. Edwards
Keyword(s):  
Creatine Kinase ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Serum Creatine Kinase ◽  
Carrier Status

A mathematical analysis of creatine kinase activity in the course of duchenne muscular dystrophy

1986 ◽  
Vol 9 (4) ◽  
pp. 333-340 ◽  
Author(s):  
W. Pernice ◽  
M. A. Guggolz ◽  
M. Guggolz ◽  
R. Beckmann ◽  
U. Wais
Keyword(s):  
Creatine Kinase ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Mathematical Analysis ◽  
Kinase Activity ◽  
Creatine Kinase Activity

The contribution of assays for lymphocyte capping and creatine kinase to detection of the Becker-type dystrophy trait.

1980 ◽  
Vol 26 (6) ◽  
pp. 754-759
Author(s):  
B M Goldsmith ◽  
H D Gruemer ◽  
R J Hawley ◽  
N A Pickard ◽  
H L Verrill ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Differential Diagnosis ◽  
Muscular Dystrophy ◽  
Kinase Activity ◽  
Reference Intervals ◽  
Creatine Kinase Activity ◽  
Serum Creatine Kinase ◽  
Healthy Controls ◽  
Tests And Measurements ◽  
Normal Controls

Abstract Members of three unrelated families with the mild Becker type of muscular dystrophy were subjected to lymphocyte capping tests and measurements of serum creatine kinase activity. Both tests correctly identified all nine affected males, but only the capping test was abnormal in seven of eight obligate carriers. The number of capped cells in carriers and affected persons with the Becker-type dystrophy was generally intermediate between those observed for individuals with the Duchenne trait and normal controls, thus potentially aiding in the differential diagnosis between the two myopathies. The lack of sensitivity of measurements of serum creatine kinase activity in identifying carriers is further complicated by the difficulty of establishing reliable reference intervals for this enzyme in 204 healthy controls. Detailed directions for the performance of the capping test are presented.

Creatine kinase activity in normal and duchenne muscular dystrophy fibroblasts

1982 ◽  
Vol 5 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Michael H. Davis ◽  
Roseann Cappel ◽  
John W. Vester ◽  
Frederick J. Samaha ◽  
Eric Gruenstein
Keyword(s):  
Creatine Kinase ◽  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Kinase Activity ◽  
Creatine Kinase Activity
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